Phenotypes Associated with This Genotype

Genotype
MGI:5428448

• Allelic Composition: Snap25^Bdr/Snap25⁺
• Genetic Background: involves: BALB/cAnNCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:119733 )

N • mice exhibit normal activity levels, startle response amplitude, anxiety-related behavior and spatial learning

ataxia ( J:119733 )

• at 4 weeks

impaired coordination ( J:119733 )

endocrine/exocrine glands

decreased glucagon secretion ( J:119733 )

• basal and stimulated

abnormal pancreatic beta cell physiology ( J:119733 )

• defective vesicle turnover and exocytosis after depletion of intermediate and readily releasable pools

decreased insulin secretion ( J:119733 )

• basal and stimulated

homeostasis/metabolism

decreased glucagon secretion ( J:119733 )

• basal and stimulated

decreased insulin secretion ( J:119733 )

• basal and stimulated

nervous system

abnormal miniature excitatory postsynaptic currents ( J:119733 )

• reduced frequency but not amplitude

decreased prepulse inhibition ( J:119733 )

decreased synaptic glutamate release ( J:119733 )

• sponataneous and evoked

taste/olfaction

taste/olfaction phenotype ( J:119733 )

N • mice exhibit normal olfaction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:119733