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Spi1
Gene Detail
Symbol

Name
ID
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
MGI:98282
Synonyms
Dis-1, PU.1, Sfpi1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr2:91082390-91115756 bp, + strand
From VEGA annotation of GRCm38

  33367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: transcription factor Spi-B
Gene Tree: Spi1
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(12) Targeted(22)
Genomic Mutations involving Spi1 (2)
 
Nullizygous mice may exhibit fetal or perinatal lethality, absence of myeloid and B cells, and altered T cell and NK cell development. Mice carrying hypomorphic alleles display impaired B-cell and myeloid development, develop T cell derived lymphomas and acute myeloid leukemia, and die prematurely.
 
Human Diseases Modeled Using Mouse Spi1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Spi1 interacts with 60 markers (Mir18, Mir27b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process anatomical structure regression, apoptotic process involved in patterning of blood vessels, ...
Component nuclear chromatin, nucleus, ...
Function DNA binding, NFAT protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (286)    Tissues (237)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
Northern blot 4
RT-PCR 30
RNase protection 9
cDNA source data(43)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(69) Genomic(21) cDNA(43) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014371 (Evidence)
Ensembl Gene ModelENSMUSG00000002111 (Evidence)
Entrez Gene100862024, 20375
UniGene1302
DFCITC1578699
DoTSDT.530145
NIA Mouse Gene IndexU002118
PDB1PUE
Consensus CDS ProjectCCDS16425.1
International Mouse Knockout Project StatusSpi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014371 VEGA Gene Model | MGI Sequence Detail 33367 C57BL/6J ±  kb
transcript OTTMUST00000033994 VEGA | MGI Sequence Detail 2034 Not Applicable 
polypeptide OTTMUSP00000015228 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(36) UniProt(7)
Polymorphisms
RFLP(7) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000001944 transcription factor PU.1
References
(Earliest) J:8990 Moreau-Gachelin F, et al., Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature. 1988 Jan 21;331(6153):277-80
(Latest) J:214351 Basova P, et al., Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Oncogene. 2014 Sep 25;33(39):4735-45
All references(236)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14369, MGD-MRK-14370, MGD-MRK-14764, MGD-MRK-15047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory