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Spi1 Gene Detail
Summary
  • Symbol
    Spi1
  • Name
    spleen focus forming virus (SFFV) proviral integration oncogene
  • Synonyms
    Dis-1, PU.1, Sfpi1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98282
    NCBI Gene: 20375
  • Gene Overview
    MyGene.info: SPI1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91082390-91115756 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.44 cM, cytoband E3
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98282
protein coding gene Chr2:91082374-91115759 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026141
protein coding gene Chr2:92389098-92422359 (+)
A/J MGP_AJ_G0026102
protein coding gene Chr2:88691831-88727038 (+)
AKR/J MGP_AKRJ_G0026083
protein coding gene Chr2:91144790-91178073 (+)
BALB/cJ MGP_BALBcJ_G0026111
protein coding gene Chr2:88856452-88904563 (+)
C3H/HeJ MGP_C3HHeJ_G0025862
protein coding gene Chr2:91420443-91455959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026562
protein coding gene Chr2:95635753-95674793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023953
protein coding gene Chr2:85207276-85240764 (+)
CAST/EiJ MGP_CASTEiJ_G0025327
protein coding gene Chr2:91944732-91979558 (+)
CBA/J MGP_CBAJ_G0025840
protein coding gene Chr2:98899020-98933234 (+)
DBA/2J MGP_DBA2J_G0025976
protein coding gene Chr2:88293094-88326083 (+)
FVB/NJ MGP_FVBNJ_G0025939
protein coding gene Chr2:87395404-87430335 (+)
LP/J MGP_LPJ_G0026080
protein coding gene Chr2:92594867-92631459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025965
protein coding gene Chr2:101936027-101972038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026616
protein coding gene Chr2:91204226-91241572 (+)
PWK/PhJ MGP_PWKPhJ_G0025062
protein coding gene Chr2:88021061-88055141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024863
protein coding gene Chr2:90783593-90817092 (+)
WSB/EiJ MGP_WSBEiJ_G0025394
protein coding gene Chr2:91798208-91836834 (+)



Homology
more
  • Human Ortholog
    SPI1, Spi-1 proto-oncogene
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SPI1, Spi-1 proto-oncogene
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OF, PU.1, SFPI1, SPI-1, SPI-A
  • Links
    NCBI Gene ID: 6688
    neXtProt AC: NX_P17947
    UniProt: P17947

  • Chr Location
    11p11.2; chr11:47354858-47395640 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Spi1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    94 phenotypes from 17 alleles in 21 genetic backgrounds
    17 phenotypes from multigenic genotypes
    125 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit fetal or perinatal lethality, absence of myeloid and B cells, and altered T cell and NK cell development. Mice carrying hypomorphic alleles display impaired B-cell and myeloid development, develop T cell derived lymphomas andacute myeloid leukemia, and die prematurely.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002111 Ensembl Gene Model | MGI Sequence Detail 33367 C57BL/6J ±  kb
    transcript ENSMUST00000002180 Ensembl | MGI Sequence Detail 2034 Not Applicable  
    polypeptide ENSMUSP00000002180 Ensembl | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 21
      cDNA 44
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14369, MGD-MRK-14370, MGD-MRK-14764, MGD-MRK-15047
    References
    more
    • Summaries
      All 317
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 29
      Phenotypes 125
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266578 Plein A, et al., Erythro-myeloid progenitors contribute endothelial cells to blood vessels. Nature. 2018 Oct;562(7726):223-228

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory