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Spi1
Gene Detail
Symbol

Name
ID
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
MGI:98282
Synonyms
Dis-1, PU.1, Sfpi1, Sfpi-1, Spi-1, Tcfpu1, Tfpu.1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(30)
Sequence Map
Chr2:91082390-91115756 bp, + strand
From VEGA annotation of GRCm38

  33367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2346  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPI1
Protein SuperFamily: transcription factor Spi-B
Gene Tree: Spi1

Human
homologs
SPI1, Spi-1 proto-oncogene
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6688
neXtProt AC: NX_P17947

Human Synonyms: OF, PU.1, SFPI1, SPI-1, SPI-A

Human Chr (Location): 11p11.2; chr11:47354858-47395640 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(12) Targeted(23)
Genomic Mutations involving Spi1 (2)
 
Nullizygous mice may exhibit fetal or perinatal lethality, absence of myeloid and B cells, and altered T cell and NK cell development. Mice carrying hypomorphic alleles display impaired B-cell and myeloid development, develop T cell derived lymphomas and acute myeloid leukemia, and die prematurely.
 
Human Diseases Modeled in Mice Using Spi1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Spi1 interacts with 60 markers (Mir18, Mir27b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process anatomical structure regression, apoptotic process involved in patterning of blood vessels, ...
Component nuclear chromatin, nucleus, ...
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (286)    Tissues (237)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
Northern blot 4
RT-PCR 30
RNase protection 9
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SPI1 ; Xenbase spi1 ; ZFIN spi1a, spi1b    NEW 
Molecular
reagents
All nucleic(69) Genomic(21) cDNA(43) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014371 (Evidence)
Ensembl Gene Model ENSMUSG00000002111 (Evidence)
Entrez Gene 20375 (Evidence)
UniGene 1302
DFCI TC1578699
DoTS DT.530145
NIA Mouse Gene Index U002118
PDB 1PUE
Consensus CDS Project CCDS16425.1
International Mouse Phenotyping Consortium Status Spi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014371 VEGA Gene Model | MGI Sequence Detail 33367 C57BL/6J ±  kb
transcript OTTMUST00000033994 VEGA | MGI Sequence Detail 2034 Not Applicable 
polypeptide OTTMUSP00000015228 VEGA | MGI Sequence Detail 272 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(7) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000001944 transcription factor PU.1
References
(Earliest) J:8990 Moreau-Gachelin F, et al., Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature. 1988 Jan 21;331(6153):277-80
(Latest) J:218696 Staber PB, et al., The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood. 2014 Oct 9;124(15):2391-9
All references(236)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14369, MGD-MRK-14370, MGD-MRK-14764, MGD-MRK-15047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory