Spi1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spi1
Spi-1 proto-oncogene
MGI:98282

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
\Runx1^tm3Spe/\Runx1^tm3Spe \Spi1^tm2.1Dgt/\Spi1^tm2.1Dgt \Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	decreased B cell number	J:131217
	decreased thymus weight	J:131217
	increased granulocyte number	J:131217
	increased spleen weight	J:131217
\Spi1^tm1Ram/\Spi1^tm1Ram \Tg(SOD1G93A)1Gur/0 involves: 129S2/SvPas C57BL/6 * SJL	decreased motor neuron number	J:116087
	normal growth/size/body region phenotype	J:116087
	motor neuron degeneration	J:116087
	premature death	J:116087
\Spi1^tm1Sing/\Spi1⁺ \Spib^tm1Mcs/\Spib⁺ involves: 129S/SvEv * 129X1/SvJ	abnormal spleen germinal center morphology	J:88257
	decreased B cell proliferation	J:88257
	normal hematopoietic system phenotype	J:88257
\Spi1^tm1Sing/\Spi1⁺ \Spib^tm1Mcs/\Spib^tm1Mcs involves: 129S/SvEv * 129X1/SvJ	abnormal B cell differentiation	J:88257
	abnormal immature B cell morphology	J:88257
	absent spleen germinal center	J:88257
	decreased B cell number	J:88257
	decreased B cell proliferation	J:88257
	normal immune system phenotype	J:88257
	increased B cell apoptosis	J:88257
\Spi1^tm1Sing/\Spi1^tm1Sing \Spib^tm1Mcs/\Spib^tm1Mcs involves: 129S/SvEv * 129X1/SvJ	lethality throughout fetal growth and development, complete penetrance	J:88257

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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