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Rxra
Gene Detail
 Symbol
Name
ID
Rxra
retinoid X receptor alpha
MGI:98214
Synonyms 9530071D11Rik, RXRalpha1, RXR alpha 1
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:27676440-27762957 bp, + strand
From VEGA annotation of GRCm38

  86518 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Rxra

Human
homologs
Human Homolog RXRA, retinoid X receptor, alpha
NCBI Gene ID 6256
neXtProt AC  NX_P19793
Human Synonyms  NR2B1
Human Chr (Location)  9q34.3; chr9:134326470-134440585 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Null embryos have multiple organ defects and die of cardiac failure by E14.5. Gene ablation in liver, prostate, fat or epidermis tissue-specifically affects development, function and/or neoplasia. Hypomorphic mutants develop alopecia, progressively severe dermal cysts and late corneal opacity.
 
Human Diseases Modeled Using Mouse Rxra (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Rxra interacts with 263 markers (Mir1b, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process angiogenesis involved in coronary vascular morphogenesis, camera-type eye development, ...
Component axon, nuclear chromatin, ...
Function 9-cis retinoic acid receptor activity, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (269)    Tissues (133)    Images (47)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 172
Northern blot 30
Western blot 9
RT-PCR 55
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(6) cDNA(28) Primer pair(10) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012047 (Evidence)
Ensembl Gene ModelENSMUSG00000015846 (Evidence)
Entrez Gene20181 (Evidence)
NIA Mouse Gene IndexU001539
PDB1DKF, 1XDK, 3A9E
Consensus CDS ProjectCCDS15830.1, CCDS71011.1
International Mouse Knockout Project StatusRxra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012047 VEGA Gene Model | MGI Sequence Detail 86518 C57BL/6J ±  kb
transcript OTTMUST00000028665 VEGA | MGI Sequence Detail 4905 Not Applicable 
polypeptide OTTMUSP00000012972 VEGA | MGI Sequence Detail 467 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(566 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021780 Nuclear/hormone receptor activator site AF-1
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR000003 Retinoid X receptor/HNF4
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000014372 retinoic acid receptor RXR-alpha
References (Earliest) J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
(Latest) J:202850 He Y, et al., The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling. BMC Genomics. 2013;14:575
All references(235)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14264, MGI:1925990

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory