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Rxra Gene Detail
Summary
  • Symbol
    Rxra
  • Name
    retinoid X receptor alpha
  • Synonyms
    9530071D11Rik, RXRalpha1, RXR alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98214
    NCBI Gene: 20181
  • Gene Overview
    MyGene.info: RXRA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:27676440-27762957 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86518 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    RXRA, retinoid X receptor alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RXRA, retinoid X receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NR2B1
  • Links
    NCBI Gene ID: 6256
    neXtProt AC: NX_P19793
    UniProt: P19793

  • Chr Location
    9q34.2; chr9:134326463-134440586 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Rxra mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    162 phenotypes from 11 alleles in 11 genetic backgrounds
    39 phenotypes from multigenic genotypes
    4 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null embryos have multiple organ defects and die of cardiac failure by E14.5. Gene ablation in liver, prostate, fat or epidermis tissue-specifically affects development, function and/or neoplasia. Hypomorphic mutants develop alopecia, progressively severe dermal cysts and late corneal opacity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012047 VEGA Gene Model | MGI Sequence Detail 86518 C57BL/6J ±  kb
    transcript OTTMUST00000028665 VEGA | MGI Sequence Detail 4905 Not Applicable  
    polypeptide OTTMUSP00000012972 VEGA | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      554 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 6
      cDNA 28
      Primer pair 10
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14264, MGI:1925990
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 62
      Diseases 3
      Gene Ontology 41
      Phenotypes 87
    • Earliest
      J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory