Rxra
Gene Detail

Symbol Name ID

Rxra retinoid X receptor alpha MGI:98214

Synonyms

9530071D11Rik, RXRalpha1, RXR alpha 1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr2:27676440-27762957 bp, + strand From VEGA annotation of GRCm38   86518 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2220  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Rxra

Human homologs

Human Homolog		RXRA, retinoid X receptor, alpha
NCBI Gene ID		6256
neXtProt AC		NX_P19793
Human Synonyms		NR2B1
Human Chr (Location)		9q34.3; chr9:137218316-137332431 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(12) Gene trapped(5) Chemically induced(1)
 

Null embryos have multiple organ defects and die of cardiac failure by E14.5. Gene ablation in liver, prostate, fat or epidermis tissue-specifically affects development, function and/or neoplasia. Hypomorphic mutants develop alopecia, progressively severe dermal cysts and late corneal opacity.

 
Human Diseases Modeled Using Mouse Rxra (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	angiogenesis involved in coronary vascular morphogenesis, cardiac muscle cell differentiation, ...
Component	axon, nuclear chromatin, ...
Function	9-cis retinoic acid receptor activity, chromatin DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (274)    Tissues (135)    Images (45)
Theiler Stages: 2, 3, 4, 5, 9, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	172
Northern blot	30
Western blot	8
RT-PCR	61

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(6) cDNA(28) Primer pair(9) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000012047 (Evidence)
Ensembl Gene Model	ENSMUSG00000015846 (Evidence)
Entrez Gene	20181 (Evidence)
NIA Mouse Gene Index	U001539
PDB	1DKF, 1XDK, 3A9E
Consensus CDS Project	CCDS15830.1
International Mouse Knockout Project Status	Rxra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012047	VEGA Gene Model | MGI Sequence Detail	86518	C57BL/6J
transcript	OTTMUST00000028665	VEGA | MGI Sequence Detail	4905	Not Applicable
polypeptide	OTTMUSP00000012972	VEGA | MGI Sequence Detail	467	Not Applicable

All sequences(46) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(3) : SNPs(554 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR021780	Protein of unknown function DUF3345
InterPro	IPR000003	Retinoid X receptor/HNF4
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000014372	retinoic acid receptor RXR-alpha

References

(Earliest) J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
(Latest) J:189533 Mori M, et al., Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium. Genesis. 2012 Nov;50(11):828-32
All references(229)

Other accession IDs

MGD-MRK-14264, MGI:1925990