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Rxra Gene Detail
Summary
  • Symbol
    Rxra
  • Name
    retinoid X receptor alpha
  • Synonyms
    9530071D11Rik, RXRalpha1, RXR alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98214
    NCBI Gene: 20181
  • Gene Overview
    MyGene.info: RXRA
Location & Maps
more
  • Sequence Map
    Chr2:27676440-27762957 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86518 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    RXRA, retinoid X receptor alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RXRA, retinoid X receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NR2B1
  • Links
    NCBI Gene ID: 6256
    neXtProt AC: NX_P19793

  • Chr Location
    9q34.2; chr9:134326463-134440586 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Rxra mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    149 phenotypes from 10 alleles in 10 genetic backgrounds
    39 phenotypes from multigenic genotypes
    4 images
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Gene trapped
    5
  • Targeted
    12
  • Incidental Mutations
Null embryos have multiple organ defects and die of cardiac failure by E14.5. Gene ablation in liver, prostate, fat or epidermis tissue-specifically affects development, function and/or neoplasia. Hypomorphic mutants develop alopecia, progressively severe dermal cysts and late corneal opacity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012047 VEGA Gene Model | MGI Sequence Detail 86518 C57BL/6J ±  kb
transcript OTTMUST00000028665 VEGA | MGI Sequence Detail 4905 Not Applicable  
polypeptide OTTMUSP00000012972 VEGA | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    554 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 6
    cDNA 28
    Primer pair 10
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14264, MGI:1925990
References
more
  • Summaries
    All 243
    Developmental Gene Expression 57
    Diseases 1
    Gene Ontology 40
    Phenotypes 85
  • Earliest
    J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
  • Latest
    J:234630 Bonney S, et al., Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 Jul 20;36(29):7786-801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory