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Ret Gene Detail
Summary
  • Symbol
    Ret
  • Name
    ret proto-oncogene
  • Synonyms
    c-Ret, RET51, RET9
  • Feature Type
    protein coding gene
  • IDs
    MGI:97902
    NCBI Gene: 19713
  • Gene Overview
    MyGene.info: RET
Location & Maps
more
  • Sequence Map
    Chr6:118151745-118197718 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45974 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 55.86 cM, cytoband E3-F1
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    RET, ret proto-oncogene
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RET, ret proto-oncogene
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1
  • Links
    NCBI Gene ID: 5979
    neXtProt AC: NX_P07949

  • Chr Location
    10q11.21; chr10:43077027-43130351 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with Ret mouse models; 8 with human RET associations

Human Disease Mouse Models
       Hirschsprung Disease, Susceptibility to, 1; HSCR1   OMIM: 142623 View 4 models
Multiple Endocrine Neoplasia, Type IIB; MEN2B   OMIM: 162300 View 2 models
Pheochromocytoma   OMIM: 171300 View 1 model
Thyroid Carcinoma, Familial Medullary; MTC   OMIM: 155240 View 2 "NOT" models
       Clubfoot, Congenital, with or without Deficiency of Long Bones and/or Mirror-Image Polydactyly; CCF   OMIM: 119800 View 1 model
       Central Hypoventilation Syndrome, Congenital; CCHS   OMIM: 209880
Multiple Endocrine Neoplasia, Type IIA; MEN2A   OMIM: 171400
Rearranged During Transfection Protooncogene; RET   OMIM: 164761
Renal Hypodysplasia/Aplasia 1; RHDA1   OMIM: 191830
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    134 phenotypes from 41 alleles in 39 genetic backgrounds
    35 phenotypes from multigenic genotypes
    145 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056769 VEGA Gene Model | MGI Sequence Detail 45974 C57BL/6J ±  kb
transcript OTTMUST00000140075 VEGA | MGI Sequence Detail 5456 Not Applicable  
polypeptide OTTMUSP00000073466 VEGA | MGI Sequence Detail 1115 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    260 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 52
    Genomic 1
    cDNA 42
    Primer pair 8
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13846
References
more
  • Summaries
    All 481
    Developmental Gene Expression 323
    Diseases 6
    Gene Ontology 24
    Phenotypes 145
  • Earliest
    J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
  • Latest
    J:234423 Stantcheva KK, et al., A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression. EMBO Rep. 2016 Apr;17(4):585-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory