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Ret Gene Detail
Summary
  • Symbol
    Ret
  • Name
    ret proto-oncogene
  • Synonyms
    c-Ret, RET51, RET9
  • Feature Type
    protein coding gene
  • IDs
    MGI:97902
    NCBI Gene: 19713
  • Gene Overview
    MyGene.info: RET
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:118151745-118197718 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 55.86 cM, cytoband E3-F1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97902
protein coding gene Chr6:118151745-118197744 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031184
protein coding gene Chr6:120893072-120943417 (-)
A/J MGP_AJ_G0031153
protein coding gene Chr6:116263329-116310463 (-)
AKR/J MGP_AKRJ_G0031084
protein coding gene Chr6:119392552-119438427 (-)
BALB/cJ MGP_BALBcJ_G0031164
protein coding gene Chr6:116044001-116091337 (-)
C3H/HeJ MGP_C3HHeJ_G0030545
protein coding gene Chr6:64855301-64902192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031622
protein coding gene Chr6:124007284-124056702 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028784
protein coding gene Chr6:113194916-113240621 (-)
CAST/EiJ MGP_CASTEiJ_G0030271
protein coding gene Chr6:119774134-119827059 (-)
CBA/J MGP_CBAJ_G0030847
protein coding gene Chr6:128889512-128945328 (-)
DBA/2J MGP_DBA2J_G0031003
protein coding gene Chr6:115166625-115211562 (-)
FVB/NJ MGP_FVBNJ_G0030955
protein coding gene Chr6:114299894-114346396 (-)
LP/J MGP_LPJ_G0031082
protein coding gene Chr6:120921187-120978192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030989
protein coding gene Chr6:132997155-133046643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031651
protein coding gene Chr6:119420125-119473647 (-)
PWK/PhJ MGP_PWKPhJ_G0029986
protein coding gene Chr6:114182242-114228469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029815
protein coding gene Chr6:118142813-118188614 (-)
WSB/EiJ MGP_WSBEiJ_G0030354
protein coding gene Chr6:119688316-119735517 (-)



Homology
more
  • Human Ortholog
    RET, ret proto-oncogene
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RET, ret proto-oncogene
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
  • Links
    NCBI Gene ID: 5979
    neXtProt AC: NX_P07949
    UniProt: P07949

  • Chr Location
    10q11.21; chr10:43077069-43130351 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Ret mouse models; 6 with human RET associations

Human Disease Mouse Models
      
IDs
View 4 models
IDs
View 2 models
IDs
View 1 model
      
IDs
View 1 model
      
IDs
IDs
View 2 "NOT" models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    134 phenotypes from 41 alleles in 39 genetic backgrounds
    53 phenotypes from multigenic genotypes
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030110 Ensembl Gene Model | MGI Sequence Detail 45974 C57BL/6J ±  kb
    transcript ENSMUST00000032201 Ensembl | MGI Sequence Detail 5456 Not Applicable  
    polypeptide ENSMUSP00000032201 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 43
      Primer pair 11
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13846
    References
    more
    • Summaries
      All 555
      Developmental Gene Expression 355
      Diseases 10
      Gene Ontology 27
      Phenotypes 174
    • Earliest
      J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
    • Latest
      J:265501 Kim H, et al., Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice. PLoS One. 2018;13(8):e0203391

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory