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Ret
Gene Detail
 Symbol
Name
ID
Ret
ret proto-oncogene
MGI:97902
Synonyms c-Ret, RET51, RET9
Feature Type protein coding gene
Genetic Map
Chromosome 6
55.86 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr6:118151748-118197744 bp, - strand
From NCBI annotation of GRCm38

  45997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Ret receptor type
Gene Tree: Ret

Human
homologs
Human Homolog RET, ret proto-oncogene
NCBI Gene ID 5979
neXtProt AC  NX_P07949
Human Synonyms  CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1
Human Chr (Location)  10q11.2; chr10:43077069-43130351 (+)  GRCh38
Disease Associations  (8) Diseases Associated with Human RET
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Targeted(45)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.
 
Human Diseases Modeled Using Mouse Ret (4)    Alleles Annotated to Human Diseases(5)   
Interactions
Ret interacts with 403 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, anatomical structure morphogenesis, ...
Component endosome, endosome membrane, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (284 records)
Data Summary: Results (718)    Tissues (300)    Images (158)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 30
RNA in situ 461
Northern blot 17
RT-PCR 210
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(1) cDNA(40) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030110 (Evidence)
Entrez Gene19713 (Evidence)
UniGene57199
DFCITC1583126
DoTSDT.55183667, DT.87048136
NIA Mouse Gene IndexU027786
EC2.7.10.1
PDB1UEF
Consensus CDS ProjectCCDS20470.1, CCDS39608.1
International Mouse Knockout Project StatusRet
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19713 NCBI Gene Model | MGI Sequence Detail 45997 C57BL/6J ±  kb
transcript NM_001080780 RefSeq | MGI Sequence Detail 7341 C57BL/6 
polypeptide P35546 UniProt | EBI | MGI Sequence Detail 1115 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR015919 Cadherin-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016249 Tyrosine-protein kinase, Ret receptor
Protein Ontology PR:000013895 proto-oncogene tyrosine-protein kinase receptor ret
Graphical View of Protein Domain Structure
References (Earliest) J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
(Latest) J:212403 Kim ST, et al., DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis. Dev Biol. 2014 Jun 15;390(2):160-9
All references(431)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-13846

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory