Ret
Gene Detail

Symbol Name ID

Ret ret proto-oncogene MGI:97902

Synonyms

c-Ret, RET51, RET9

Feature Type

protein coding gene

Genetic Map

Chromosome 6

55.86 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr6:118151748-118197744 bp, - strand From NCBI annotation of GRCm38   45997 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Ret receptor type
Gene Tree: Ret

Human homologs

Human Homolog		RET, ret proto-oncogene
NCBI Gene ID		5979
neXtProt AC		NX_P07949
Human Synonyms		CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1
Human Chr (Location)		10q11.2; chr10:43572517-43625799 (+)  GRCh37.p10
Disease Associations		(8) Diseases Associated with Human RET

Alleles and phenotypes

All alleles(42) : Targeted(42)
 

Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.

 
Human Diseases Modeled Using Mouse Ret (4)    Alleles Annotated to Human Diseases(5)   

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	anatomical structure morphogenesis, cell adhesion, ...
Component	endosome, endosome membrane, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (265 records)
Data Summary: Results (561)    Tissues (222)    Images (138)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	28
RNA in situ	301
Northern blot	17
RT-PCR	215

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(1) cDNA(37) Primer pair(7) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030110 (Evidence)
Entrez Gene	19713 (Evidence)
UniGene	57199
DFCI	TC1583126
DoTS	DT.55183667, DT.87048136
NIA Mouse Gene Index	U027786
EC	2.7.10.1
PDB	1UEF
Consensus CDS Project	CCDS20470.1, CCDS39608.1
International Mouse Knockout Project Status	Ret

Sequences

Length	Strain/Species
genomic	19713	NCBI Gene Model | MGI Sequence Detail	45997	C57BL/6J
transcript	NM_001080780	RefSeq | MGI Sequence Detail	7341	C57BL/6
polypeptide	P35546	UniProt | EBI | MGI Sequence Detail	1115	Not Applicable

All sequences(24) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR015919	Cadherin-like
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016249	Tyrosine-protein kinase, Ret receptor
Protein Ontology	PR:000013895	proto-oncogene tyrosine-protein kinase receptor ret

Graphical View of Protein Domain Structure

References

(Earliest) J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
(Latest) J:193269 Barlow AJ, et al., Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis. Hum Mol Genet. 2013 Mar 15;22(6):1206-17
All references(401)

Other accession IDs

MGD-MRK-13846