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Rag2
Gene Detail
Symbol

Name
ID
Rag2
recombination activating gene 2
MGI:97849
Synonyms
Rag-2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
53.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:101624718-101632529 bp, + strand
From VEGA annotation of GRCm38

  7812 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7507  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAG2
Gene Tree: Rag2

Human
homologs
RAG2, recombination activating gene 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5897
neXtProt AC: NX_P55895

Human Synonyms: RAG-2

Human Chr (Location): 11p13; chr11:36591943-36598279 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human RAG2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Targeted(16)
Genomic Mutations involving Rag2 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
 
Human Diseases Modeled in Mice Using Rag2 (2)    Mutations Annotated to Human Diseases (4)   
Interactions
Rag2 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process B cell differentiation, B cell homeostatic proliferation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (49)    Tissues (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 49
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN rag2    NEW 
Molecular
reagents
All nucleic(22) Genomic(7) cDNA(9) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014585 (Evidence)
Ensembl Gene Model ENSMUSG00000032864 (Evidence)
Entrez Gene 19374 (Evidence)
UniGene 4988
DFCI TC1584529
DoTS DT.40156481
NIA Mouse Gene Index U002161
PDB 2JWO, 4WWX, 2V83, 2V85, 2V86, 2V87, 2V88, 2V89
Consensus CDS Project CCDS16462.1
International Mouse Phenotyping Consortium Status Rag2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014585 VEGA Gene Model | MGI Sequence Detail 7812 C57BL/6J ±  kb
transcript OTTMUST00000034581 VEGA | MGI Sequence Detail 3424 Not Applicable 
polypeptide OTTMUSP00000015478 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011043 Galactose oxidase/kelch, beta-propeller
InterPro IPR015915 Kelch-type beta propeller
InterPro IPR025162 Recombination activating protein 2, PHD domain
InterPro IPR004321 V-D-J recombination activating protein 2
InterPro IPR011011 Zinc finger, FYVE/PHD-type
Protein Ontology PR:000003460 V(D)J recombination-activating protein 2
References
(Earliest) J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
(Latest) J:222172 van Roosmalen W, et al., Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant. J Clin Invest. 2015 Apr;125(4):1648-64
All references(842)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-13754, MGD-MRK-13756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory