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Rag1
Gene Detail
 Symbol
Name
ID
Rag1
recombination activating gene 1
MGI:97848
Synonyms Rag-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
53.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr2:101638282-101649501 bp, - strand
From VEGA annotation of GRCm38

  11220 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rag1

Human
homologs
Human Homolog RAG1, recombination activating gene 1
NCBI Gene ID 5896
neXtProt AC  NX_P15918
Human Synonyms  RAG-1, RNF74
Human Chr (Location)  11p13; chr11:36510372-36579762 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human RAG1
Alleles
and
phenotypes
All alleles(13) : Targeted(10) Chemically induced(3)
 
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process adaptive immune response, B cell differentiation, ...
Component nucleus
Function acid-amino acid ligase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (138)    Tissues (82)    Images (3)
Theiler Stages: 10, 13, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 24
Northern blot 11
RT-PCR 103
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(44) Genomic(12) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014584 (Evidence)
Ensembl Gene ModelENSMUSG00000061311 (Evidence)
Entrez Gene19373 (Evidence)
UniGene828
DFCITC1609480, TC1637274
DoTSDT.94226024
EC3.1.-.-, 6.3.2.-
PDB1RMD, 3GNA, 3GNB
Consensus CDS ProjectCCDS16463.1
International Mouse Knockout Project StatusRag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014584 VEGA Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
transcript OTTMUST00000034580 VEGA | MGI Sequence Detail 6608 Not Applicable 
polypeptide OTTMUSP00000015477 VEGA | MGI Sequence Detail 1040 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms RFLP(4) : SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023336 RAG nonamer-binding domain
InterPro IPR024627 Recombination-activation protein 1
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
InterPro IPR019485 Zinc finger, V(D)J recombination-activating protein 1
Protein Ontology PR:000003457 V(D)J recombination-activating protein 1
References (Earliest) J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
(Latest) J:207097 Saucillo DC, et al., Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol. 2014 Jan 1;192(1):136-44
All references(1000)
Other
accession IDs
MGD-MRK-13753, MGD-MRK-13755

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory