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Rag1 Gene Detail
Summary
  • Symbol
    Rag1
  • Name
    recombination activating gene 1
  • Synonyms
    Rag-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97848
    NCBI Gene: 19373
  • Gene Overview
    MyGene.info: RAG1
Location & Maps
more
  • Sequence Map
    Chr2:101638282-101649501 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11220 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 53.88 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    RAG1, recombination activating gene 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAG1, recombination activating gene 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RAG-1, RNF74
  • Links
    NCBI Gene ID: 5896
    neXtProt AC: NX_P15918

  • Chr Location
    11p13; chr11:36510400-36579762 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 387
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RAG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Rag1 mouse models; 4 with human RAG1 associations

Human Disease Mouse Models
       Omenn Syndrome   OMIM: 603554 View 1 "NOT" model
       Alpha/Beta T-Cell Lymphopenia with Gamma/Delta T-Cell Expansion, Severe Cytomegalovirus Infection, and Autoimmunity   OMIM: 609889
Combined Cellular and Humoral Immune Defects with Granulomas; CCHIDG   OMIM: 233650
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive   OMIM: 601457
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 11 alleles in 17 genetic backgrounds
    175 phenotypes from multigenic genotypes
    1 images
    1032 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    13
  • Genomic Mutations
    4 involving Rag1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014584 VEGA Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
transcript OTTMUST00000034580 VEGA | MGI Sequence Detail 6608 Not Applicable  
polypeptide OTTMUSP00000015477 VEGA | MGI Sequence Detail 1040 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    192 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 12
    cDNA 26
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13753, MGD-MRK-13755
References
more
  • Summaries
    All 1189
    Developmental Gene Expression 18
    Diseases 5
    Gene Ontology 23
    Phenotypes 1032
  • Earliest
    J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
  • Latest
    J:232115 Chandrakanthan V, et al., PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory