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Rag1 Gene Detail
Summary
  • Symbol
    Rag1
  • Name
    recombination activating gene 1
  • Synonyms
    Rag-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97848
    NCBI Gene: 19373
  • Gene Overview
    MyGene.info: RAG1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:101638282-101649501 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 53.88 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97848
protein coding gene Chr2:101638252-101649532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026190
protein coding gene Chr2:103508950-103520166 (-)
A/J MGP_AJ_G0026151
protein coding gene Chr2:99236713-99247930 (-)
AKR/J MGP_AKRJ_G0026132
protein coding gene Chr2:101939265-101950481 (-)
BALB/cJ MGP_BALBcJ_G0026160
protein coding gene Chr2:99540846-99552061 (-)
C3H/HeJ MGP_C3HHeJ_G0025911
protein coding gene Chr2:102305886-102317104 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026611
protein coding gene Chr2:107014169-107025388 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024002
protein coding gene Chr2:94942211-94953437 (-)
CAST/EiJ MGP_CASTEiJ_G0025376
protein coding gene Chr2:102723021-102734264 (-)
CBA/J MGP_CBAJ_G0025889
protein coding gene Chr2:110704403-110715617 (-)
DBA/2J MGP_DBA2J_G0026025
protein coding gene Chr2:98820406-98831620 (-)
FVB/NJ MGP_FVBNJ_G0025988
protein coding gene Chr2:97822407-97833646 (-)
LP/J MGP_LPJ_G0026129
protein coding gene Chr2:103668615-103679860 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026014
protein coding gene Chr2:114682783-114694024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026665
protein coding gene Chr2:102156615-102167835 (-)
PWK/PhJ MGP_PWKPhJ_G0025111
protein coding gene Chr2:98295783-98307002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024912
protein coding gene Chr2:101366076-101377281 (-)
WSB/EiJ MGP_WSBEiJ_G0025443
protein coding gene Chr2:102856430-102867654 (-)



Homology
more
  • Human Ortholog
    RAG1, recombination activating 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAG1, recombination activating 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAG-1, RNF74
  • Links
    NCBI Gene ID: 5896
    neXtProt AC: NX_P15918
    UniProt: P15918

  • Chr Location
    11p12; chr11:36510366-36579762 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 387
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RAG1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human RAG1 associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 11 alleles in 17 genetic backgrounds
    181 phenotypes from multigenic genotypes
    1 images
    1235 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061311 Ensembl Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
    transcript ENSMUST00000078494 Ensembl | MGI Sequence Detail 6608 Not Applicable  
    polypeptide ENSMUSP00000077584 Ensembl | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 13
      cDNA 26
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13753, MGD-MRK-13755
    References
    more
    • Summaries
      All 1427
      Developmental Gene Expression 18
      Diseases 5
      Gene Ontology 23
      Phenotypes 1235
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:267972 Douam F, et al., Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018 Nov 28;9(1):5031

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    01/15/2019
    MGI 6.13
    The Jackson Laboratory