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Rag1 Gene Detail
Summary
  • Symbol
    Rag1
  • Name
    recombination activating gene 1
  • Synonyms
    Rag-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97848
    NCBI Gene: 19373
  • Gene Overview
    MyGene.info: RAG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:101638282-101649501 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11220 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 53.88 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    RAG1, recombination activating 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAG1, recombination activating 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAG-1, RNF74
  • Links
    NCBI Gene ID: 5896
    neXtProt AC: NX_P15918
    UniProt: P15918

  • Chr Location
    11p12; chr11:36510366-36579762 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 387
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RAG1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human RAG1 associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 11 alleles in 17 genetic backgrounds
    181 phenotypes from multigenic genotypes
    1 images
    1180 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014584 VEGA Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
    transcript OTTMUST00000034580 VEGA | MGI Sequence Detail 6608 Not Applicable  
    polypeptide OTTMUSP00000015477 VEGA | MGI Sequence Detail 1040 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      192 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 13
      cDNA 26
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13753, MGD-MRK-13755
    References
    more
    • Summaries
      All 1374
      Developmental Gene Expression 18
      Diseases 5
      Gene Ontology 23
      Phenotypes 1180
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263173 Bou Ghanem EN, et al., Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138(+) Cells. J Immunol. 2018 Jun 1;200(11):3739-3751

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory