Rag1
Gene Detail

Symbol Name ID

Rag1 recombination activating gene 1 MGI:97848

Synonyms

Rag-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

53.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr2:101638282-101649501 bp, - strand From VEGA annotation of GRCm38   11220 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rag1

Human homologs

Human Homolog		RAG1, recombination activating gene 1
NCBI Gene ID		5896
neXtProt AC		NX_P15918
Human Synonyms		RAG-1, RNF74
Human Chr (Location)		11p13; chr11:36589563-36601312 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human RAG1

Alleles and phenotypes

All alleles(13) : Targeted(10) Chemically induced(3)
 

Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	adaptive immune response, B cell differentiation, ...
Component	nucleus
Function	acid-amino acid ligase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (138)    Tissues (82)    Images (3)
Theiler Stages: 10, 13, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	24
Northern blot	11
RT-PCR	103

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(12) cDNA(27) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014584 (Evidence)
Ensembl Gene Model	ENSMUSG00000061311 (Evidence)
Entrez Gene	19373 (Evidence)
UniGene	828
DFCI	TC1609480, TC1637274
DoTS	DT.94226024
EC	3.1.-.-, 6.3.2.-
PDB	1RMD, 3GNA, 3GNB
Consensus CDS Project	CCDS16463.1
International Mouse Knockout Project Status	Rag1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014584	VEGA Gene Model | MGI Sequence Detail	11220	C57BL/6J
transcript	OTTMUST00000034580	VEGA | MGI Sequence Detail	6608	Not Applicable
polypeptide	OTTMUSP00000015477	VEGA | MGI Sequence Detail	1040	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(4) : SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023336	RAG nonamer-binding domain
InterPro	IPR024627	Recombination-activation protein 1
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
InterPro	IPR019485	Zinc finger, V(D)J recombination-activating protein 1
Protein Ontology	PR:000003457	V(D)J recombination-activating protein 1

References

(Earliest) J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
(Latest) J:196056 Fuchs A, et al., Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-gamma-Producing Cells. Immunity. 2013 Apr 18;38(4):769-81
All references(914)

Other accession IDs

MGD-MRK-13753, MGD-MRK-13755