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Rag1
Gene Detail
Symbol

Name
ID
Rag1
recombination activating gene 1
MGI:97848
Synonyms
Rag-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
53.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr2:101638282-101649501 bp, - strand
From VEGA annotation of GRCm38

  11220 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:387  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAG1
Gene Tree: Rag1

Human
homologs
RAG1, recombination activating gene 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5896
neXtProt AC: NX_P15918

Human Synonyms: RAG-1, RNF74

Human Chr (Location): 11p13; chr11:36510400-36579762 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human RAG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(4) Targeted(13)
Genomic Mutations involving Rag1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit arrested development of T and B cell maturation at the CD4-8- thymocyte or B220+/CD43+pro-B cell stage due to inability to undergo V(D)J recombination.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Rag1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process adaptive immune response, B cell differentiation, ...
Component nucleus
Function acid-amino acid ligase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (138)    Tissues (82)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 11
RT-PCR 103
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rag1 ; ZFIN rag1    NEW 
Molecular
reagents
All nucleic(44) Genomic(12) cDNA(26) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014584 (Evidence)
Ensembl Gene Model ENSMUSG00000061311 (Evidence)
Entrez Gene 19373 (Evidence)
UniGene 828
DFCI TC1609480, TC1637274
DoTS DT.94226024
EC 3.1.-.-, 6.3.2.-
PDB 1RMD, 3GNA, 3GNB, 4WWX
Consensus CDS Project CCDS16463.1
International Mouse Phenotyping Consortium Status Rag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014584 VEGA Gene Model | MGI Sequence Detail 11220 C57BL/6J ±  kb
transcript OTTMUST00000034580 VEGA | MGI Sequence Detail 6608 Not Applicable 
polypeptide OTTMUSP00000015477 VEGA | MGI Sequence Detail 1040 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023336 RAG nonamer-binding domain
InterPro IPR024627 Recombination-activation protein 1
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
InterPro IPR019485 Zinc finger, V(D)J recombination-activating protein 1
Protein Ontology PR:000003457 V(D)J recombination-activating protein 1
References
(Earliest) J:10163 Schatz DG, et al., The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22;59(6):1035-48
(Latest) J:222628 Hao B, et al., An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J Exp Med. 2015 May 4;212(5):809-24
All references(1122)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13753, MGD-MRK-13755

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory