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Raf1
Gene Detail
Symbol

Name
ID
Raf1
v-raf-leukemia viral oncogene 1
MGI:97847
Synonyms
6430402F14Rik, c-Raf, Craf1, Raf-1, sarcoma 3611 oncogene, v-Raf
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.62 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(54)
Sequence Map
Chr6:115618067-115676635 bp, - strand
From VEGA annotation of GRCm38

  58569 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: RAF proto-oncogene serine/threonine-protein kinase
Gene Tree: Raf1

Human
homologs
Human Homolog RAF1, Raf-1 proto-oncogene, serine/threonine kinase
NCBI Gene ID 5894
neXtProt AC  NX_P04049
Human Synonyms  CMD1NN, c-Raf, CRAF, NS5, Raf-1
Human Chr (Location)  3p25; chr3:12583601-12664201 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human RAF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(157) : Gene trapped(143) Targeted(13) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations are growth retarded, with hypocellular fetal livers, placental anomalies, and defects of skin and lungs, resulting in lethality around mid-gestation. Mice heterozygous for a knock-in allele exhibit hypertrophic cardiomyopathy.
 
Human Diseases Modeled Using Mouse Raf1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Raf1 interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process activation of MAPKK activity, cell differentiation, ...
Component cytoplasm, cytosol, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (123)    Tissues (70)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 25
Northern blot 63
RT-PCR 27
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(4) cDNA(20) Primer pair(3) Other(7)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020697 (Evidence)
Ensembl Gene ModelENSMUSG00000000441 (Evidence)
Entrez Gene110157 (Evidence)
DFCITC1571969, TC1603648, TC1657728, TC1733209
EC2.7.11.1
Consensus CDS ProjectCCDS20441.1
International Mouse Knockout Project StatusRaf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020697 VEGA Gene Model | MGI Sequence Detail 58569 C57BL/6J ±  kb
transcript OTTMUST00000048985 VEGA | MGI Sequence Detail 2946 Not Applicable 
polypeptide OTTMUSP00000022609 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(9)
Polymorphisms
RFLP(10) : SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000003244 RAF proto-oncogene serine/threonine-protein kinase
References
(Earliest) J:7145 Rapp UR, et al., Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4218-22
(Latest) J:213126 O'Donovan KJ, et al., B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
All references(185)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13751, MGD-MRK-13752, MGI:1277195, MGI:1924126, MGI:2141729, MGI:2146790

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory