Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables MAP kinase kinase kinase activity and small GTPase binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and neuromuscular junction development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; insulin secretion involved in cellular response to glucose stimulus; and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in pseudopodium. Is expressed in several structures, including alimentary system; blastocyst-stage conceptus; central nervous system; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase).

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Gene Ontology Evidence Code Abbreviations:

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