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Ptpra Gene Detail
Summary
  • Symbol
    Ptpra
  • Name
    protein tyrosine phosphatase, receptor type, A
  • Synonyms
    Ptpa, PTP[a], PTPalpha, RPTPalpha, RPTRalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:97808
    NCBI Gene: 19262
  • Gene Overview
    MyGene.info: PTPRA
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130450251-130554300 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.23 cM, cytoband G
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    619 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97808
protein coding gene Chr2:130450251-130556124 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026506
protein coding gene Chr2:133909868-134017027 (+)
A/J MGP_AJ_G0026470
protein coding gene Chr2:128490080-128597801 (+)
AKR/J MGP_AKRJ_G0026445
protein coding gene Chr2:132192519-132301368 (+)
BALB/cJ MGP_BALBcJ_G0026482
protein coding gene Chr2:128843834-128948129 (+)
C3H/HeJ MGP_C3HHeJ_G0026225
protein coding gene Chr2:132626803-132737595 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026927
protein coding gene Chr2:138051465-138157101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024304
protein coding gene Chr2:123231027-123336178 (+)
CAST/EiJ MGP_CASTEiJ_G0025686
protein coding gene Chr2:132880442-132988951 (+)
CBA/J MGP_CBAJ_G0026205
protein coding gene Chr2:143155767-143263412 (+)
DBA/2J MGP_DBA2J_G0026339
protein coding gene Chr2:127877083-127984900 (+)
FVB/NJ MGP_FVBNJ_G0026303
protein coding gene Chr2:126502326-126607431 (+)
LP/J MGP_LPJ_G0026444
protein coding gene Chr2:134161439-134265336 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026323
protein coding gene Chr2:147009474-147116128 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026982
protein coding gene Chr2:132151578-132260834 (+)
PWK/PhJ MGP_PWKPhJ_G0025422
protein coding gene Chr2:127430633-127538346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025224
protein coding gene Chr2:131270969-131380542 (+)
WSB/EiJ MGP_WSBEiJ_G0025760
protein coding gene Chr2:133073620-133184499 (+)



Homology
more
  • Human Ortholog
    PTPRA, protein tyrosine phosphatase receptor type A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRA, protein tyrosine phosphatase receptor type A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, RPTPA, R-PTP-alpha
  • Links
    NCBI Gene ID: 5786
    neXtProt AC: NX_P18433
    UniProt: P18433

  • Chr Location
    20p13; chr20:2864195-3038669 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit deficits in Morris water maze learning, reduced locomotor activity, and decreased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19262 NCBI Gene Model | MGI Sequence Detail 104050 C57BL/6J ±  kb
    transcript NM_008980 RefSeq | MGI Sequence Detail 3609 C57BL/6  
    polypeptide P18052 UniProt | EBI | MGI Sequence Detail 829 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 14
      cDNA 25
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13673, MGD-MRK-13677
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 8
      Gene Ontology 15
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:269100 Dyck S, et al., LAR and PTPsigma receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury. Glia. 2019 Jan;67(1):125-145

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory