Ptpra MGI Mouse Gene Detail - MGI:97808 - protein tyrosine phosphatase receptor type A

Symbol

Ptpra
Name

protein tyrosine phosphatase receptor type A
Synonyms

Ptpa, PTP[a], PTPalpha, RPTPalpha, RPTRalpha

Feature Type

protein coding gene
IDs

MGI:97808
NCBI Gene: 19262
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:130292198-130396220 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.23 cM, cytoband G
Mapping Data

17 experiments

SNPs within 2kb

619 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97808	protein coding gene	Chr2:130292198-130398044 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026506	protein coding gene	Chr2:133909868-134017027 (+)
A/J	MGP_AJ_G0026470	protein coding gene	Chr2:128490080-128597801 (+)
AKR/J	MGP_AKRJ_G0026445	protein coding gene	Chr2:132192519-132301368 (+)
BALB/cJ	MGP_BALBcJ_G0026482	protein coding gene	Chr2:128843834-128948129 (+)
C3H/HeJ	MGP_C3HHeJ_G0026225	protein coding gene	Chr2:132626803-132737595 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026927	protein coding gene	Chr2:138051465-138157101 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024304	protein coding gene	Chr2:123231027-123336178 (+)
CAST/EiJ	MGP_CASTEiJ_G0025686	protein coding gene	Chr2:132880442-132988951 (+)
CBA/J	MGP_CBAJ_G0026205	protein coding gene	Chr2:143155767-143263412 (+)
DBA/2J	MGP_DBA2J_G0026339	protein coding gene	Chr2:127877083-127984900 (+)
FVB/NJ	MGP_FVBNJ_G0026303	protein coding gene	Chr2:126502326-126607431 (+)
LP/J	MGP_LPJ_G0026444	protein coding gene	Chr2:134161439-134265336 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026323	protein coding gene	Chr2:147009474-147116128 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026982	protein coding gene	Chr2:132151578-132260834 (+)
PWK/PhJ	MGP_PWKPhJ_G0025422	protein coding gene	Chr2:127430633-127538346 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025224	protein coding gene	Chr2:131270969-131380542 (+)
WSB/EiJ	MGP_WSBEiJ_G0025760	protein coding gene	Chr2:133073620-133184499 (+)

Human Ortholog

PTPRA, protein tyrosine phosphatase receptor type A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPRA, protein tyrosine phosphatase receptor type A
Synonyms

HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, RPTPA, R-PTP-alpha
Links

HGNC:9664

NCBI Gene ID: 5786

neXtProt AC: NX_P18433

UniProt: P18433
Chr Location

20p13; chr20:2864184-3039076 (+) GRCh38

MGI Vertebrate Homology

Ptpra stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPRA
Protein SuperFamily

PTPR_alpha_epsilon
Gene Tree

Ptpra

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Phenotype Summary

15 phenotypes from 4 alleles in 6 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Ptpra
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit deficits in Morris water maze learning, reduced locomotor activity, and decreased anxiety.

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All GO Annotations

27
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

61
cDNA Data

23
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PTPRA

Xenbase ptpra

ZFIN ptpra

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All Sequences

87
RefSeq

8
UniProt

4
CCDS

CCDS16743.1, CCDS50712.1

Ensembl

ENSMUSG00000027303 (Evidence)
NCBI Gene

19262

			Length	Strain/Species	Flank
genomic	19262	NCBI Gene Model \| MGI Sequence Detail	104023	C57BL/6J	± kb
transcript	NM_008980	RefSeq \| MGI Sequence Detail	3609	ZRU/MplStud
polypeptide	P18052	UniProt \| EBI \| MGI Sequence Detail	829	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013464 receptor-type tyrosine-protein phosphatase alpha

(term hierarchy)
PDB

1P15, 1YFO
EC

3.1.3.48
InterPro Domains

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR027262 Receptor tyrosine-protein phosphatase alpha

IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 43

Genomic 14

cDNA 26

Other 3

Microarray probesets 6

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MGD-MRK-13673, MGD-MRK-13677

Summaries

All 99

Developmental Gene Expression 9

Gene Ontology 15

Phenotypes 29
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:344874 Bai Y, et al., PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. Autophagy. 2023 May;19(5):1562-1581

TSS for Ptpra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20211	Chr2:130292179-130292229 (+)	6 bp
Tssr20212	Chr2:130292230-130292246 (+)	40 bp
Tssr20213	Chr2:130292249-130292269 (+)	61 bp
Tssr20214	Chr2:130292299-130292304 (+)	104 bp
Tssr20215	Chr2:130321621-130321631 (+)	29,428 bp
Tssr20216	Chr2:130324302-130324318 (+)	32,112 bp
Tssr20217	Chr2:130332477-130332481 (+)	40,281 bp
Tssr20218	Chr2:130345901-130345906 (+)	53,706 bp
Tssr20219	Chr2:130346200-130346228 (+)	54,016 bp
Tssr20220	Chr2:130381330-130381344 (+)	89,139 bp
Tssr20221	Chr2:130381349-130381358 (+)	89,156 bp
Tssr20222	Chr2:130381446-130381454 (+)	89,252 bp
Tssr20223	Chr2:130383215-130383243 (+)	91,031 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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