Ptgs1
Gene Detail

Symbol Name ID

Ptgs1 prostaglandin-endoperoxide synthase 1 MGI:97797

Synonyms

Cox-1, COX1, Cox-3, cyclooxygenase 1, Pghs1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

24.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr2:36230426-36252272 bp, + strand From VEGA annotation of GRCm38   21847 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prostaglandin-endoperoxide synthase
Gene Tree: Ptgs1

Human homologs

Human Homolog		PTGS1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Gene ID		5742
neXtProt AC		NX_P23219
Human Synonyms		COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS1, PGHS-1, PHS1, PTGHS
Human Chr (Location)		9q32-q33.3; chr9:125132809-125157982 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Null mutants show impaired platelet aggregation, reduced inflammatory responses, and diminished susceptibility to induced papillomas. Female mutants exhibit delayed parturition and their offspring die neonatally.

 
Human Diseases Modeled Using Mouse Ptgs1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	cyclooxygenase pathway, fatty acid biosynthetic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	heme binding, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (137)    Tissues (103)    Images (38)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	131
RT-PCR	6

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(4) cDNA(53) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000012142 (Evidence)
Ensembl Gene Model	ENSMUSG00000047250 (Evidence)
Entrez Gene	19224 (Evidence)
UniGene	275434
DFCI	TC1574327, TC1590831
DoTS	DT.101393045, DT.490882, DT.91558959
NIA Mouse Gene Index	U053942
EC	1.14.99.1
Consensus CDS Project	CCDS15970.1
International Mouse Knockout Project Status	Ptgs1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012142	VEGA Gene Model | MGI Sequence Detail	21847	C57BL/6J
transcript	OTTMUST00000028971	VEGA | MGI Sequence Detail	2867	Not Applicable
polypeptide	OTTMUSP00000013094	VEGA | MGI Sequence Detail	602	Not Applicable

All sequences(46) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(3) : SNPs(91 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR010255	Haem peroxidase
InterPro	IPR002007	Haem peroxidase, animal
InterPro	IPR019791	Haem peroxidase, animal, subgroup
Protein Ontology	PR:000013427	prostaglandin G/H synthase 1

References

(Earliest) J:17450 DeWitt DL, et al., The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J Biol Chem. 1990 Mar 25;265(9):5192-8
(Latest) J:196419 Yang CW, et al., Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process. J Exp Med. 2013 Feb 11;210(2):375-87
All references(186)

Other accession IDs

MGD-MRK-13664