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Ptgs1
Gene Detail
 Symbol
Name
ID
Ptgs1
prostaglandin-endoperoxide synthase 1
MGI:97797
Synonyms Cox-1, COX1, Cox-3, cyclooxygenase 1, Pghs1
Feature Type protein coding gene
Genetic Map
Chromosome 2
24.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:36230426-36252272 bp, + strand
From VEGA annotation of GRCm38

  21847 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prostaglandin-endoperoxide synthase
Gene Tree: Ptgs1

Human
homologs
Human Homolog PTGS1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
NCBI Gene ID 5742
neXtProt AC  NX_P23219
Human Synonyms  COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS1, PGHS-1, PHS1, PTGHS
Human Chr (Location)  9q32-q33.3; chr9:122370530-122395703 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Null mutants show impaired platelet aggregation, reduced inflammatory responses, and diminished susceptibility to induced papillomas. Female mutants exhibit delayed parturition and their offspring die neonatally.
 
Human Diseases Modeled Using Mouse Ptgs1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cyclooxygenase pathway, fatty acid biosynthetic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function dioxygenase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (137)    Tissues (103)    Images (38)
Theiler Stages: 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 131
RT-PCR 6
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(4) cDNA(52) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012142 (Evidence)
Ensembl Gene ModelENSMUSG00000047250 (Evidence)
Entrez Gene19224 (Evidence)
UniGene275434
DFCITC1574327, TC1590831
DoTSDT.101393045, DT.490882, DT.91558959
NIA Mouse Gene IndexU053942
EC1.14.99.1
Consensus CDS ProjectCCDS15970.1
International Mouse Knockout Project StatusPtgs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012142 VEGA Gene Model | MGI Sequence Detail 21847 C57BL/6J ±  kb
transcript OTTMUST00000028971 VEGA | MGI Sequence Detail 2867 Not Applicable 
polypeptide OTTMUSP00000013094 VEGA | MGI Sequence Detail 602 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR010255 Haem peroxidase
InterPro IPR002007 Haem peroxidase, animal
InterPro IPR019791 Haem peroxidase, animal, subgroup
Protein Ontology PR:000013427 prostaglandin G/H synthase 1
References (Earliest) J:17450 DeWitt DL, et al., The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J Biol Chem. 1990 Mar 25;265(9):5192-8
(Latest) J:204709 Kirkby NS, et al., LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS One. 2013;8(7):e69524
All references(191)
Other
accession IDs
MGD-MRK-13664

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory