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Ptgs1 Gene Detail
Summary
  • Symbol
    Ptgs1
  • Name
    prostaglandin-endoperoxide synthase 1
  • Synonyms
    Cox-1, COX1, Cox-3, cyclooxygenase 1, Pghs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97797
    NCBI Gene: 19224
  • Gene Overview
    MyGene.info: PTGS1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:36230426-36252272 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 24.19 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97797
protein coding gene Chr2:36216744-36252275 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025663
protein coding gene Chr2:34918575-34940133 (+)
A/J MGP_AJ_G0025640
protein coding gene Chr2:33432622-33454430 (+)
AKR/J MGP_AKRJ_G0025610
protein coding gene Chr2:34602412-34624777 (+)
BALB/cJ MGP_BALBcJ_G0025637
protein coding gene Chr2:33544333-33566104 (+)
C3H/HeJ MGP_C3HHeJ_G0025397
protein coding gene Chr2:34509928-34531555 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026081
protein coding gene Chr2:35893760-35918413 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023490
protein coding gene Chr2:32120159-32142036 (+)
CAST/EiJ MGP_CASTEiJ_G0024859
protein coding gene Chr2:34494965-34518815 (+)
CBA/J MGP_CBAJ_G0025375
protein coding gene Chr2:37294547-37316397 (+)
DBA/2J MGP_DBA2J_G0025508
protein coding gene Chr2:33199939-33221585 (+)
FVB/NJ MGP_FVBNJ_G0025470
protein coding gene Chr2:33111616-33133598 (+)
LP/J MGP_LPJ_G0025594
protein coding gene Chr2:34844051-34865788 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025501
protein coding gene Chr2:36753372-36775832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026139
protein coding gene Chr2:34497790-34520529 (+)
PWK/PhJ MGP_PWKPhJ_G0024607
protein coding gene Chr2:33124914-33146990 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024407
protein coding gene Chr2:34677519-34698629 (+)
WSB/EiJ MGP_WSBEiJ_G0024928
protein coding gene Chr2:34697331-34720891 (+)



Homology
more
  • Human Ortholog
    PTGS1, prostaglandin-endoperoxide synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTGS1, prostaglandin-endoperoxide synthase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS1, PGHS-1, PHS1, PTGHS
  • Links
    NCBI Gene ID: 5742
    neXtProt AC: NX_P23219
    UniProt: P23219

  • Chr Location
    9q33.2; chr9:122369906-122395703 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ptgs1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 2 alleles in 11 genetic backgrounds
    31 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mutants show impaired platelet aggregation, reduced inflammatory responses, and diminished susceptibility to induced papillomas. Female mutants exhibit delayed parturition and their offspring die neonatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047250 Ensembl Gene Model | MGI Sequence Detail 21847 C57BL/6J ±  kb
    transcript ENSMUST00000062069 Ensembl | MGI Sequence Detail 2867 Not Applicable  
    polypeptide ENSMUSP00000059977 Ensembl | MGI Sequence Detail 602 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 4
      cDNA 54
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13664
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 9
      Phenotypes 122
    • Earliest
      J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
    • Latest
      J:262233 Theisen E, et al., Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria-Stimulated Immunity. J Immunol. 2018 Jun 1;200(11):3729-3738

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory