60 phenotypes from 3 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ptgs1em1(IMPC)Mbp/Ptgs1em1(IMPC)Mbp C57BL/6NCrl-Ptgs1em1(IMPC)Mbp/MbpMmucd	abnormal auditory brainstem response	J:211773
	abnormal cecum morphology	J:211773
	enlarged cecum	J:211773
Ptgs1tm1Fun/Ptgs1tm1Fun involves: 129S6/SvEvTac * C57BL/6	abnormal thromboxane level	J:108957
	decreased inflammatory response	J:97351
	decreased platelet aggregation	J:97351
	decreased susceptibility to induced thrombosis	J:97351
	decreased urine prostaglandin level	J:108957
	increased bleeding time	J:97351
	normal reproductive system phenotype	J:97351
Ptgs1tm1Unc/Ptgs1+ D1.129P2-Ptgs1tm1Unc	normal growth/size/body region phenotype	J:102779
	increased prostaglandin level	J:102779
Ptgs1tm1Unc/Ptgs1+ involves: 129P2/OlaHsd * C57BL/6	decreased prostaglandin level	J:29511
Ptgs1tm1Unc/Ptgs1+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased prostaglandin level	J:106147
Ptgs1tm1Unc/Ptgs1tm1Unc B6.129P2-Ptgs1tm1Unc	abnormal drinking behavior	J:125586
	abnormal nociception after inflammation	J:110716
	abnormal response/metabolism to endogenous compounds	J:125586
	allodynia	J:110716
	decreased brain blood flow rate	J:115589
	decreased physiological sensitivity to xenobiotic	J:115589
	decreased susceptibility to induced arthritis	J:110716
	increased bronchoconstrictive response	J:141201
	increased thermal nociceptive threshold	J:110716
Ptgs1tm1Unc/Ptgs1tm1Unc B6;129P2-Ptgs1tm1Unc/Tac	abnormal stomach pH	J:103642
	normal behavior/neurological phenotype	J:141610
	decreased digestive secretion	J:103642
	decreased physiological sensitivity to xenobiotic	J:103642
	normal homeostasis/metabolism phenotype	J:112346
	normal muscle phenotype	J:107751
	normal nervous system phenotype	J:141610
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129/Sv * 129P2/OlaHsd * C57BL/6	normal homeostasis/metabolism phenotype	J:124756
	normal skeleton phenotype	J:124756
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd	abnormal small intestine crypts of Lieberkuhn morphology	J:108679
	decreased prostaglandin level	J:108679
	increased cellular sensitivity to gamma-irradiation	J:108679
	increased small intestinal crypt cell apoptosis	J:108679
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * C57BL/6	abnormal blood coagulation	J:29511
	abnormal blood flow velocity	J:110043
	abnormal circadian regulation of heart rate	J:110043
	abnormal circadian regulation of systemic arterial blood pressure	J:110043
	abnormal corpus luteum morphology	J:50148
	abnormal keratinocyte differentiation	J:117986
	abnormal kidney morphology	J:29511
	abnormal parturition	J:50148
	abnormal response of heart to induced stress	J:103388
	abnormal urine homeostasis	J:110043
	abnormal uterine environment	J:29511
	decreased inflammatory response	J:29511
	decreased physiological sensitivity to xenobiotic	J:146321
	decreased platelet aggregation	J:29511
	decreased prostaglandin level	J:29511, J:50148, J:60668, J:103388, J:117986
	decreased urine prostaglandin level	J:110043
	delayed parturition	J:64073
	normal digestive/alimentary phenotype	J:29511, J:60668
	enlarged spleen	J:60668
	hypotonia	J:146321
	increased circulating progesterone level	J:50148
	increased mean systemic arterial blood pressure	J:110043
	increased renal glomerular filtration rate	J:110043
	increased renal vascular resistance	J:110043
	increased susceptibility to endotoxin shock	J:75611
	increased susceptibility to induced colitis	J:60668, J:158426
	increased susceptibility to injury	J:60668
	increased susceptibility to xenobiotic induced morbidity/mortality	J:60668
	normal neoplasm	J:158426
	perinatal lethality, incomplete penetrance	J:64073
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * C57BL/6 * CD-1	delayed parturition	J:64073
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * C57BL/6 * DBA/1	abnormal wound healing	J:126734
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * C57BL/6 * DBA/2	decreased prostaglandin level	J:106147
Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * C57BL/6J	normal cardiovascular system phenotype	J:109021
	delayed parturition	J:144423
	normal homeostasis/metabolism phenotype	J:54450
	maternal effect	J:144423