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Prox1 Gene Detail
Summary
  • Symbol
    Prox1
  • Name
    prospero homeobox 1
  • Synonyms
    A230003G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97772
    NCBI Gene: 19130
  • Gene Overview
    MyGene.info: PROX1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190118035-190170680 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 95.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97772
protein coding gene Chr1:190118035-190170714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016931
protein coding gene Chr1:197075866-197129433 (-)
A/J MGP_AJ_G0016910
protein coding gene Chr1:189003364-189056700 (-)
AKR/J MGP_AKRJ_G0016875
protein coding gene Chr1:194583195-194636385 (-)
BALB/cJ MGP_BALBcJ_G0016868
protein coding gene Chr1:189678274-189731303 (-)
C3H/HeJ MGP_C3HHeJ_G0016692
protein coding gene Chr1:195452905-195506049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017331
protein coding gene Chr1:203361239-203415584 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015038
protein coding gene Chr1:179919308-179972717 (-)
CAST/EiJ MGP_CASTEiJ_G0016275
protein coding gene Chr1:195017939-195071891 (-)
CBA/J MGP_CBAJ_G0016666
protein coding gene Chr1:210949139-211002105 (-)
DBA/2J MGP_DBA2J_G0016772
protein coding gene Chr1:187742159-187794715 (-)
FVB/NJ MGP_FVBNJ_G0016768
protein coding gene Chr1:185856214-185909657 (-)
LP/J MGP_LPJ_G0016847
protein coding gene Chr1:198257656-198311361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016800
protein coding gene Chr1:217639166-217694941 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017368
protein coding gene Chr1:194492641-194546565 (-)
PWK/PhJ MGP_PWKPhJ_G0016062
protein coding gene Chr1:187007957-187061079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015838
protein coding gene Chr1:193452186-193513781 (-)
WSB/EiJ MGP_WSBEiJ_G0016337
protein coding gene Chr1:194698800-194753048 (-)



Homology
more
  • Human Ortholog
    PROX1, prospero homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROX1, prospero homeobox 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 5629
    neXtProt AC: NX_Q92786
    UniProt: Q92786

  • Chr Location
    1q32.3; chr1:213983239-214041510 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2069
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PROX1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Prox1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 6 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19130 NCBI Gene Model | MGI Sequence Detail 52646 C57BL/6J ±  kb
    transcript NM_008937 RefSeq | MGI Sequence Detail 8026 C57BL/6  
    polypeptide P48437 UniProt | EBI | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 21
      Primer pair 7
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13626, MGI:2443651
    References
    more
    • Summaries
      All 500
      Developmental Gene Expression 413
      Diseases 2
      Gene Ontology 22
      Phenotypes 71
    • Earliest
      J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
    • Latest
      J:266924 Louveau A, et al., CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. 2018 Oct;21(10):1380-1391

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory