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Prox1
Gene Detail
 Symbol
Name
ID
Prox1
prospero homeobox 1
MGI:97772
Synonyms A230003G05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
95.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:190118038-190170680 bp, - strand
From VEGA annotation of GRCm38

  52643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prox1

Human
homologs
Human Homolog PROX1, prospero homeobox 1
NCBI Gene ID 5629
neXtProt AC  NX_Q92786
Human Chr (Location)  1q41; chr1:213987935-214041510 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Targeted(9)
 
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
 
Human Diseases Modeled Using Mouse Prox1 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, ...
Component cytoplasm, nucleus
Function DBD domain binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (268 records)
Data Summary: Results (584)    Tissues (245)    Images (142)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 70
RNA in situ 463
In situ reporter (knock in) 27
RT-PCR 24
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(1) cDNA(19) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040162 (Evidence)
Ensembl Gene ModelENSMUSG00000010175 (Evidence)
Entrez Gene19130 (Evidence)
DFCITC1584495, TC1598198
DoTSDT.101705973, DT.485322
NIA Mouse Gene IndexU022193, U232045
Consensus CDS ProjectCCDS35822.1
International Mouse Knockout Project StatusProx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040162 VEGA Gene Model | MGI Sequence Detail 52643 C57BL/6J ±  kb
transcript OTTMUST00000104400 VEGA | MGI Sequence Detail 7876 Not Applicable 
polypeptide OTTMUSP00000058419 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR023082 Homeo-prospero domain
InterPro IPR007738 Prospero homeobox protein 1
Protein Ontology PR:000013273 prospero homeobox protein 1
References (Earliest) J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
(Latest) J:207255 Zhu Y, et al., Active cochlear amplification is dependent on supporting cell gap junctions. Nat Commun. 2013;4:1786
All references(321)
Other
accession IDs
MGD-MRK-13626, MGI:2443651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory