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Prox1 Gene Detail
Summary
  • Symbol
    Prox1
  • Name
    prospero homeobox 1
  • Synonyms
    A230003G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97772
    NCBI Gene: 19130
  • Gene Overview
    MyGene.info: PROX1
Location & Maps
more
  • Sequence Map
    Chr1:190118035-190170714 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52680 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 95.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PROX1, prospero homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROX1, prospero homeobox 1
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 5629
    neXtProt AC: NX_Q92786

  • Chr Location
    1q41; chr1:213983226-214041510 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2069
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PROX1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Prox1 mouse models

Human Disease Mouse Models
       Lymphangiectasia, Pulmonary, Congenital; CPL   OMIM: 265300 View 1 model
Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 5 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040162 VEGA Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
transcript OTTMUST00000104400 VEGA | MGI Sequence Detail 7913 Not Applicable  
polypeptide OTTMUSP00000058419 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    316 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 1
    cDNA 20
    Primer pair 6
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13626, MGI:2443651
References
more
  • Summaries
    All 399
    Developmental Gene Expression 344
    Diseases 1
    Gene Ontology 20
    Phenotypes 45
  • Earliest
    J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
  • Latest
    J:231667 Munger SJ, et al., Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016 Apr 15;412(2):173-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory