About   Help   FAQ
Prox1
Gene Detail
Symbol

Name
ID
Prox1
prospero homeobox 1
MGI:97772
Synonyms
A230003G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
95.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:190118035-190170714 bp, - strand
From VEGA annotation of GRCm38

  52680 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Prox1

Human
homologs
Human Homolog PROX1, prospero homeobox 1
NCBI Gene ID 5629
neXtProt AC  NX_Q92786
Human Chr (Location)  1q41; chr1:213987935-214041510 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
 
Human Diseases Modeled Using Mouse Prox1 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Prox1 interacts with 477 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (293 records)
Data Summary: Results (630)    Tissues (277)    Images (188)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 114
RNA in situ 465
In situ reporter (knock in) 27
RT-PCR 24
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(20) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040162 (Evidence)
Ensembl Gene ModelENSMUSG00000010175 (Evidence)
Entrez Gene19130 (Evidence)
DFCITC1584495, TC1598198
DoTSDT.101705973, DT.485322
NIA Mouse Gene IndexU022193, U232045
Consensus CDS ProjectCCDS35822.1
International Mouse Knockout Project StatusProx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040162 VEGA Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
transcript OTTMUST00000104400 VEGA | MGI Sequence Detail 7913 Not Applicable 
polypeptide OTTMUSP00000058419 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR023082 Homeo-prospero domain
InterPro IPR007738 Prospero homeobox protein 1
Protein Ontology PR:000013273 prospero homeobox protein 1
References
(Earliest) J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
(Latest) J:213874 Murtomaki A, et al., Notch signaling functions in lymphatic valve formation. Development. 2014 Jun;141(12):2446-51
All references(353)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13626, MGI:2443651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory