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Prox1
Gene Detail
Symbol

Name
ID
Prox1
prospero homeobox 1
MGI:97772
Synonyms
A230003G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
95.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:190118035-190170714 bp, - strand
From VEGA annotation of GRCm38

  52680 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PROX1
Gene Tree: Prox1

Human
homologs
PROX1, prospero homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5629
neXtProt AC: NX_Q92786

Human Chr (Location): 1q41; chr1:213983226-214041510 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities
 
Human Diseases Modeled in Mice Using Prox1 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Prox1 interacts with 476 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (316 records)
Data Summary: Results (643)    Tissues (284)    Images (188)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 123
RNA in situ 465
In situ reporter (knock in) 28
Western blot 3
RT-PCR 24
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PROX1 ; Xenbase prox1 ; ZFIN prox1a    NEW 
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(20) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000040162 (Evidence)
Ensembl Gene Model ENSMUSG00000010175 (Evidence)
Entrez Gene 19130 (Evidence)
DFCI TC1584495, TC1598198
DoTS DT.101705973, DT.485322
NIA Mouse Gene Index U022193, U232045
Consensus CDS Project CCDS35822.1
International Mouse Phenotyping Consortium Status Prox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040162 VEGA Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
transcript OTTMUST00000104401 VEGA | MGI Sequence Detail 3285 Not Applicable 
polypeptide OTTMUSP00000058420 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR023082 Homeo-prospero domain
InterPro IPR007738 Prospero homeobox protein 1
Protein Ontology PR:000013273 prospero homeobox protein 1
References
(Earliest) J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
(Latest) J:219234 Wang J, et al., FGF signaling is required for anterior but not posterior specification of the murine liver bud. Dev Dyn. 2015 Mar;244(3):431-43
All references(374)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13626, MGI:2443651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory