Prox1
Gene Detail

Symbol Name ID

Prox1 prospero-related homeobox 1 MGI:97772

Synonyms

A230003G05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

95.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:190118038-190170680 bp, - strand From VEGA annotation of GRCm38   52643 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2069  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prox1

Human homologs

Human Homolog		PROX1, prospero homeobox 1
NCBI Gene ID		5629
neXtProt AC		NX_Q92786
Human Chr (Location)		1q41; chr1:214161278-214214853 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygous mutation of this gene results in embryonic lethality with impaired development of the lens, lymphatic system, liver and pancreas. Heterozygous mutation results in early postnatal lethality with varying penetrance on different genetic backgrounds, obesity and lymphatic vessel abnormalities

 
Human Diseases Modeled Using Mouse Prox1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (65 annotations)

Process	aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, ...
Component	cytoplasm, nucleus
Function	DBD domain binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (243 records)
Data Summary: Results (541)    Tissues (223)    Images (123)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	30
RNA in situ	460
In situ reporter (knock in)	27
RT-PCR	24

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(19) Primer pair(5) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000040162 (Evidence)
Ensembl Gene Model	ENSMUSG00000010175 (Evidence)
Entrez Gene	19130 (Evidence)
DFCI	TC1584495, TC1598198
DoTS	DT.101705973, DT.485322
NIA Mouse Gene Index	U022193, U232045
Consensus CDS Project	CCDS35822.1
International Mouse Knockout Project Status	Prox1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040162	VEGA Gene Model | MGI Sequence Detail	52643	C57BL/6J
transcript	OTTMUST00000104400	VEGA | MGI Sequence Detail	7876	Not Applicable
polypeptide	OTTMUSP00000058419	VEGA | MGI Sequence Detail	737	Not Applicable

All sequences(35) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(199 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009057	Homeodomain-like
InterPro	IPR023082	Homeo-prospero domain
InterPro	IPR007738	Prospero homeobox protein 1
Protein Ontology	PR:000013273	prospero homeobox protein 1
Protein Ontology	PR:000027748	prospero homeobox protein 1 (mouse)

References

(Earliest) J:16397 Oliver G, et al., Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev. 1993 Nov;44(1):3-16
(Latest) J:193897 Mellado Lagarde MM, et al., Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice. J Neurosci. 2013 Jan 23;33(4):1564-76
All references(292)

Other accession IDs

MGD-MRK-13626, MGI:2443651