61 phenotypes from 6 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prox1tm1.1Fuma/Prox1tm1.1Fuma Tg(Camk2a-cre)20Kmik/0 involves: C57BL/6NCrlj * CBA/JNCrlj	abnormal dentate gyrus morphology	J:187615
	abnormal hippocampus CA4 region morphology	J:187615
	abnormal hippocampus granule cell morphology	J:187615
Prox1tm1.1Fuma/Prox1tm1.1Fuma Tg(Camk2a-cre/ERT2)2Gsc/0 involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N	abnormal dentate gyrus morphology	J:187615
	abnormal hippocampus CA4 region morphology	J:187615
	abnormal hippocampus granule cell morphology	J:187615
Prox1tm1Gco/Prox1+ involves: 129S1/Sv * 129X1/SvJ	abnormal lymph circulation	J:57646
	postnatal lethality, complete penetrance	J:53431
Prox1tm1Gco/Prox1+ involves: 129S1/Sv * 129X1/SvJ * NMRI	abnormal eye development	J:83185
	abnormal intestine morphology	J:102652
	abnormal lymph circulation	J:57646, J:102652
	abnormal lymphatic vessel morphology	J:102652
	abnormal retina morphology	J:83185
	abnormal suckling behavior	J:102652
	chylothorax	J:102652
	cyanosis	J:102652
	decreased locomotor activity	J:102652
	edema	J:57646, J:102652
	hepatic steatosis	J:102652
	increased circulating alanine transaminase level	J:102652
	increased circulating glucagon level	J:102652
	increased circulating insulin level	J:102652
	increased circulating leptin level	J:102652
	increased fat cell size	J:102652
	increased inflammatory response	J:102652
	increased liver triglyceride level	J:102652
	increased macrophage cell number	J:102652
	increased susceptibility to age related obesity	J:102652
	increased total body fat amount	J:102652
	increased total fat pad weight	J:102652
	increased total retina thickness	J:83185
	postnatal lethality, incomplete penetrance	J:53431, J:102652
	respiratory distress	J:102652
Prox1tm1Gco/Prox1tm1Gco involves: 129S1/Sv * 129X1/SvJ * NMRI	abnormal endocrine pancreas morphology	J:103538
	abnormal eye development	J:83185
	abnormal lens development	J:53431
	abnormal lens morphology	J:53431
	abnormal liver development	J:63128
	abnormal lymph organ development	J:57646
	absent retina horizontal cells	J:83185
	normal cardiovascular system phenotype	J:57646
	decreased hepatocyte proliferation	J:63128
	edema	J:57646
	increased pancreatic acinar cell number	J:103538
	lethality throughout fetal growth and development, complete penetrance	J:53431, J:57646
	small liver	J:63128
	small pancreas	J:103538
Prox1tm1Gco/Prox1tm2Gco Tg(Tek-cre)1Ywa/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	absent lymphatic vessels	J:125507
Prox1tm1Gco/Prox1tm5(GFP/cre)Gco involves: 129S1/Sv * 129X1/SvJ * NMRI	decreased lymphatic vessel endothelial cell number	J:158959
Prox1tm2Gco/Prox1+ Tg(Tek-cre)1Ywa/0 involves: 129S1/Sv * C57BL/6 * NMRI * SJL	abnormal intestine morphology	J:102652
	abnormal lymph circulation	J:102652
	abnormal lymphatic vessel morphology	J:102652
	chylothorax	J:102652
	edema	J:102652
	increased susceptibility to age related obesity	J:102652
	postnatal lethality, incomplete penetrance	J:102652
Prox1tm2Gco/Prox1tm2Gco Myf5tm3(cre)Sor/Myf5+ involves: 129S1/Sv * 129S4/SvJae * C57BL/6J	abnormal skeletal muscle morphology	J:212185
Prox1tm2Gco/Prox1tm2Gco Nkx2-5tm1(cre)Rjs/Nkx2-5+ involves: 129S1/Sv * 129S7/SvEvBrd	abnormal atrial thrombosis	J:212185
	abnormal cardiac thrombosis	J:212185
	abnormal heart morphology	J:212185
	abnormal interventricular septum morphology	J:212185
	abnormal interventricular septum muscular part morphology	J:212185
	abnormal myocardial fiber morphology	J:212185
	abnormal ventricular thrombosis	J:212185
	decreased cardiac muscle contractility	J:212185
	dilated cardiomyopathy	J:212185
	dilated heart	J:212185
	enlarged heart	J:212185
	interventricular septum membranous part aneurysm	J:212185
	postnatal lethality, incomplete penetrance	J:212185
	premature death	J:212185
	thick tricuspid valve cusps	J:212185
	thin myocardium	J:212185
Prox1tm3(cre/ERT2)Gco/Prox1tm3(cre/ERT2)Gco involves: 129S1/Sv	no abnormal phenotype detected	J:125507
Prox1tm4.1Gco/Prox1+ involves: 129S1/Sv * C57BL/10 * CBA/Ca	normal cardiovascular system phenotype	J:158959
Prox1tm4.1Gco/Prox1tm4.1Gco involves: 129S1/Sv * C57BL/10 * CBA/Ca	decreased lymphatic vessel endothelial cell number	J:158959
	edema	J:158959
Prox1tm5(GFP/cre)Gco/Prox1+ involves: 129S1/Sv * NMRI	decreased survivor rate	J:158959