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Pln
Gene Detail
 Symbol
Name
ID
Pln
phospholamban
MGI:97622
Synonyms PLB
Feature Type protein coding gene
Genetic Map
Chromosome 10
27.11 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:53337686-53345999 bp, + strand
From NCBI annotation of GRCm38

  8314 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2002  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cardiac phospholamban
Gene Tree: Pln

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Homozygotes for a targeted null mutation exhibit enhanced myocardial function without altered heart rate, but do not respond to the beta-agonist isoproterenol. Mutants are overtly normal and fertile.
 
Interactions
Pln interacts with 217 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process adrenergic receptor signaling pathway involved in heart process, calcium ion transport, ...
Component cell, endoplasmic reticulum, ...
Function ATPase inhibitor activity, calcium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (140)    Tissues (123)    Images (29)
Theiler Stages: 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 129
Western blot 8
RT-PCR 3
cDNA source data(160)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(162) cDNA(161) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000038583 (Evidence)
Entrez Gene18821 (Evidence)
UniGene34145
DFCITC1574272, TC1652352, TC1680533
DoTSDT.535699, DT.94201484, DT.94201494
NIA Mouse Gene IndexU011510
PDB3O7L
Consensus CDS ProjectCCDS35899.1
International Mouse Knockout Project StatusPln
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18821 NCBI Gene Model | MGI Sequence Detail 8314 C57BL/6J ±  kb
transcript NM_001141927 RefSeq | MGI Sequence Detail 2480 C57BL/6 
polypeptide P61014 UniProt | EBI | MGI Sequence Detail 52 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005984 Phospholamban
Protein Ontology PR:000012875 cardiac phospholamban
Graphical View of Protein Domain Structure
References (Earliest) J:3416 Ganim JR, et al., Mouse phospholamban gene expression during development in vivo and in vitro. Circ Res. 1992 Nov;71(5):1021-30
(Latest) J:211451 Kalyanasundaram A, et al., Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2. Cardiovasc Res. 2013 May 1;98(2):297-306
All references(115)
Other
accession IDs
MGD-MRK-13362

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory