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Pln Gene Detail
Summary
  • Symbol
    Pln
  • Name
    phospholamban
  • Synonyms
    PLB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97622
    NCBI Gene: 18821
  • Gene Overview
    MyGene.info: PLN
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:53337686-53345999 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 27.11 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97622
protein coding gene Chr10:53337667-53345999 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017229
protein coding gene Chr10:52518370-52526683 (+)
A/J MGP_AJ_G0017205
protein coding gene Chr10:50966159-50974450 (+)
AKR/J MGP_AKRJ_G0017164
protein coding gene Chr10:51972351-51980370 (+)
BALB/cJ MGP_BALBcJ_G0017166
protein coding gene Chr10:51109865-51118564 (+)
C3H/HeJ MGP_C3HHeJ_G0016988
protein coding gene Chr10:52227450-52236560 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017625
protein coding gene Chr10:54165922-54174139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015319
protein coding gene Chr10:48141965-48150531 (+)
CAST/EiJ MGP_CASTEiJ_G0016562
protein coding gene Chr10:52317543-52328984 (+)
CBA/J MGP_CBAJ_G0016961
protein coding gene Chr10:56473587-56484695 (+)
DBA/2J MGP_DBA2J_G0017066
protein coding gene Chr10:50406518-50414729 (+)
FVB/NJ MGP_FVBNJ_G0017060
protein coding gene Chr10:49701336-49709648 (+)
LP/J MGP_LPJ_G0017141
protein coding gene Chr10:52590196-52599187 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017089
protein coding gene Chr10:58424437-58434672 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017660
protein coding gene Chr10:51878283-51887331 (+)
PWK/PhJ MGP_PWKPhJ_G0016343
protein coding gene Chr10:50244786-50253604 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016128
protein coding gene Chr10:51497697-51505921 (+)
WSB/EiJ MGP_WSBEiJ_G0016627
protein coding gene Chr10:52123742-52133308 (+)



Homology
more
  • Human Ortholog
    PLN, phospholamban
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PLN, phospholamban
    Orthology source: HGNC
  • Synonyms
    CMD1P, CMH18, PLB
  • Links
    NCBI Gene ID: 5350
    neXtProt AC: NX_P26678
    UniProt: P26678

  • Chr Location
    6q22.31; chr6:118548263-118561715 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Pln mouse models; 2 with human PLN associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 7 alleles in 6 genetic backgrounds
    38 phenotypes from multigenic genotypes
    1 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit enhanced myocardial function without altered heart rate, but do not respond to the beta-agonist isoproterenol. Mutants are overtly normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18821 NCBI Gene Model | MGI Sequence Detail 8314 C57BL/6J ±  kb
    transcript NM_001141927 RefSeq | MGI Sequence Detail 2480 C57BL/6  
    polypeptide P61014 UniProt | EBI | MGI Sequence Detail 52 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 167
      cDNA 163
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13362
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 20
      Diseases 3
      Gene Ontology 17
      Phenotypes 91
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:256541 Lezcano N, et al., Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca(2+) handling in cardiomyocytes. J Mol Cell Cardiol. 2018 Jan;114:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory