Pln
Gene Detail

Symbol Name ID

Pln phospholamban MGI:97622

Synonyms

PLB

Feature Type

protein coding gene

Genetic Map

Chromosome 10

27.11 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:53337686-53345999 bp, + strand From NCBI annotation of GRCm38   8314 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cardiac phospholamban
Gene Tree: Pln

Human homologs

Human Homolog		PLN, phospholamban
NCBI Gene ID		5350
neXtProt AC		NX_P26678
Human Synonyms		CMD1P, CMH18, PLB
Human Chr (Location)		6q22.1; chr6:118869442-118881587 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PLN

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for a targeted null mutation exhibit enhanced myocardial function without altered heart rate, but do not respond to the beta-agonist isoproterenol. Mutants are overtly normal and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	adrenergic receptor signaling pathway involved in heart process, calcium ion transport, ...
Component	calcium ion-transporting ATPase complex, integral to membrane, ...
Function	ATPase inhibitor activity, calcium channel regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (140)    Tissues (122)    Images (29)
Theiler Stages: 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	129
Western blot	8
RT-PCR	3

cDNA source data(159)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000038583 (Evidence)
Entrez Gene	18821 (Evidence)
UniGene	34145
DFCI	TC1574272, TC1652352, TC1680533
DoTS	DT.535699, DT.94201484, DT.94201494
NIA Mouse Gene Index	U011510
PDB	3O7L
Consensus CDS Project	CCDS35899.1
International Mouse Knockout Project Status	Pln

Sequences

Length	Strain/Species
genomic	18821	NCBI Gene Model | MGI Sequence Detail	8314	C57BL/6J
transcript	NM_001141927	RefSeq | MGI Sequence Detail	2480	C57BL/6
polypeptide	P61014	UniProt | EBI | MGI Sequence Detail	52	Not Applicable

All sequences(32) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005984	Phospholamban
Protein Ontology	PR:000012875	cardiac phospholamban

Graphical View of Protein Domain Structure

References

(Earliest) J:3416 Ganim JR, et al., Mouse phospholamban gene expression during development in vivo and in vitro. Circ Res. 1992 Nov;71(5):1021-30
(Latest) J:186692 Wu Y, et al., CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep;53(3):429-36
All references(112)

Other accession IDs

MGD-MRK-13362