Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein homodimerization activity. Involved in acrosome assembly; intracellular calcium ion homeostasis; and negative regulation of calcium ion import into sarcoplasmic reticulum. Acts upstream of or within several processes, including adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; muscle cell cellular homeostasis; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban).