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Ntrk2 Gene Detail
Summary
  • Symbol
    Ntrk2
  • Name
    neurotrophic tyrosine kinase, receptor, type 2
  • Synonyms
    C030027L06Rik, Tkrb, trkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97384
    NCBI Gene: 18212
  • Gene Overview
    MyGene.info: NTRK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:58806569-59133970 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      327402 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 31.20 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE58, GP145-TrkB, OBHD, trk-B, TRKB
  • Links
    NCBI Gene ID: 4915
    neXtProt AC: NX_Q16620
    UniProt: Q16620

  • Chr Location
    9q21.33; chr9:84668368-85027070 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    139 phenotypes from 20 alleles in 27 genetic backgrounds
    13 phenotypes from multigenic genotypes
    192 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18212 NCBI Gene Model | MGI Sequence Detail 327402 C57BL/6J ±  kb
    transcript NM_001025074 RefSeq | MGI Sequence Detail 8744 C57BL/6  
    polypeptide P15209 UniProt | EBI | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      3095 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 28
      Primer pair 16
      Other 4

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299
    References
    more
    • Summaries
      All 451
      Developmental Gene Expression 153
      Gene Ontology 38
      Phenotypes 192
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:260652 Quarta E, et al., Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice. Mol Cell Neurosci. 2018 Mar 24;89:33-41

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory