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Ntrk2 Gene Detail
Summary
  • Symbol
    Ntrk2
  • Name
    neurotrophic tyrosine kinase, receptor, type 2
  • Synonyms
    C030027L06Rik, Tkrb, trkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97384
    NCBI Gene: 18212
  • Gene Overview
    MyGene.info: NTRK2
Location & Maps
more
  • Sequence Map
    Chr13:58806596-59133970 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      327375 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 31.20 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP145-TrkB, trk-B, TRKB
  • Links
    NCBI Gene ID: 4915
    neXtProt AC: NX_Q16620

  • Chr Location
    9q22.1; chr9:84668458-85027070 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NTRK2 associations

Human Disease Mouse Models
       Obesity, Hyperphagia, and Developmental Delay; OBHD   OMIM: 613886
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    139 phenotypes from 20 alleles in 27 genetic backgrounds
    13 phenotypes from multigenic genotypes
    178 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    23
  • Genomic Mutations
    1 involving Ntrk2
  • Incidental Mutations
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055254 Ensembl Gene Model | MGI Sequence Detail 327375 C57BL/6J ±  kb
transcript ENSMUST00000079828 Ensembl | MGI Sequence Detail 8541 Not Applicable  
polypeptide ENSMUSP00000078757 Ensembl | MGI Sequence Detail 821 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3095 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011470 BDNF/NT-3 growth factors receptor
  • EC
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR020777 Tyrosine-protein kinase, neurotrophic receptor
    IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2
    IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
Molecular
Reagents
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  • All nucleic 48
    cDNA 28
    Primer pair 16
    Other 4

    Microarray probesets 11
Other
Accession IDs
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MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299
References
more
  • Summaries
    All 385
    Developmental Gene Expression 141
    Gene Ontology 33
    Phenotypes 178
  • Earliest
    J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
  • Latest
    J:233763 Karpinski BA, et al., A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol. 2016 Jul 15;415(2):228-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory