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Ntrk2 Gene Detail
Summary
  • Symbol
    Ntrk2
  • Name
    neurotrophic tyrosine kinase, receptor, type 2
  • Synonyms
    C030027L06Rik, Tkrb, trkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97384
    NCBI Gene: 18212
  • Gene Overview
    MyGene.info: NTRK2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:58806569-59133970 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 31.20 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3095 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97384
protein coding gene Chr13:58806569-59133970 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020636
protein coding gene Chr13:58473190-58811609 (+)
A/J MGP_AJ_G0020590
protein coding gene Chr13:56295981-56615263 (+)
AKR/J MGP_AKRJ_G0020568
protein coding gene Chr13:57976403-58309050 (+)
BALB/cJ MGP_BALBcJ_G0020586
protein coding gene Chr13:56554304-56876124 (+)
C3H/HeJ MGP_C3HHeJ_G0020385
protein coding gene Chr13:57771880-58105510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021020
protein coding gene Chr13:60250267-60599545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018602
protein coding gene Chr13:54188527-54508677 (+)
CAST/EiJ MGP_CASTEiJ_G0019899
protein coding gene Chr13:57915862-58269614 (+)
CBA/J MGP_CBAJ_G0020345
protein coding gene Chr13:62522904-62879363 (+)
DBA/2J MGP_DBA2J_G0020468
protein coding gene Chr13:55841555-56168324 (+)
FVB/NJ MGP_FVBNJ_G0020447
protein coding gene Chr13:55327212-55649690 (+)
LP/J MGP_LPJ_G0020544
protein coding gene Chr13:58735278-59074297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020476
protein coding gene Chr13:61869137-62211224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021063
protein coding gene Chr13:57575323-57915824 (+)
PWK/PhJ MGP_PWKPhJ_G0019655
protein coding gene Chr13:55857429-56191636 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019482
protein coding gene Chr13:56477794-56800707 (+)
WSB/EiJ MGP_WSBEiJ_G0019961
protein coding gene Chr13:58009870-58358273 (+)



Homology
more
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EIEE58, GP145-TrkB, OBHD, trk-B, TRKB
  • Links
    NCBI Gene ID: 4915
    neXtProt AC: NX_Q16620
    UniProt: Q16620

  • Chr Location
    9q21.33; chr9:84668368-85027070 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    139 phenotypes from 20 alleles in 27 genetic backgrounds
    13 phenotypes from multigenic genotypes
    197 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18212 NCBI Gene Model | MGI Sequence Detail 327402 C57BL/6J ±  kb
    transcript NM_001025074 RefSeq | MGI Sequence Detail 8744 C57BL/6  
    polypeptide P15209 UniProt | EBI | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 30
      Primer pair 16
      Other 5

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299
    References
    more
    • Summaries
      All 464
      Developmental Gene Expression 157
      Gene Ontology 41
      Phenotypes 197
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:266259 Menard M, et al., The dependence receptor TrkC regulates the number of sensory neurons during DRG development. Dev Biol. 2018 Oct 15;442(2):249-261

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory