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Ntrk2
Gene Detail
Symbol

Name
ID
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
MGI:97384
Synonyms
C030027L06Rik, Tkrb, trkB
Feature Type
protein coding gene
Genetic Map
Chromosome 13
31.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:58806596-59133970 bp, + strand
From Ensembl annotation of GRCm38

  327375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NTRK2
Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk2

Human
homologs
NTRK2, neurotrophic tyrosine kinase, receptor, type 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4915
neXtProt AC: NX_Q16620

Human Synonyms: GP145-TrkB, trk-B, TRKB

Human Chr (Location): 9q22.1; chr9:84668458-85027070 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NTRK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(4) Targeted(23)
Incidental mutations (data from Mutagenetix , APF )
 
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
 
Interactions
Ntrk2 interacts with 493 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (135 records)
Data Summary: Results (322)    Tissues (208)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 44
RNA in situ 184
In situ reporter (knock in) 9
Northern blot 42
Western blot 6
RT-PCR 37
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NTRK2 ; Xenbase ntrk2    NEW 
Molecular
reagents
All nucleic(47) cDNA(28) Primer pair(15) Other(4)
Microarray probesets(11)
Other database
links
Ensembl Gene Model ENSMUSG00000055254 (Evidence)
Entrez Gene 18212 (Evidence)
DFCI TC1575671, TC1602361, TC1604716, TC1605566, TC1607816, TC1637892, TC1643845, TC1656841, TC1715426
DoTS DT.101721766, DT.40161626, DT.40185334, DT.60104420, DT.91327786, DT.94300623
NIA Mouse Gene Index U014925
EC 2.7.10.1
Consensus CDS Project CCDS26573.1, CCDS36685.1
International Mouse Phenotyping Consortium Status Ntrk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055254 Ensembl Gene Model | MGI Sequence Detail 327375 C57BL/6J ±  kb
transcript ENSMUST00000079828 Ensembl | MGI Sequence Detail 8541 Not Applicable 
polypeptide ENSMUSP00000078757 Ensembl | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(3118 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3126)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011470 BDNF/NT-3 growth factors receptor
References
(Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:220390 Penzo MA, et al., The paraventricular thalamus controls a central amygdala fear circuit. Nature. 2015 Mar 26;519(7544):455-9
All references(370)
Other
accession IDs
MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory