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Gene Detail
neurotrophic tyrosine kinase, receptor, type 2
Synonyms C030027L06Rik, Tkrb, trkB
Feature Type protein coding gene
Genetic Map
Chromosome 13
31.20 cM
Detailed Genetic Map ± 1 cM

Mapping data(10)
Sequence Map
Chr13:58806596-59129976 bp, + strand
From NCBI annotation of GRCm38

  323381 bp   ±  kb flank

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Mouse Genome Browser
HomoloGene:4504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk2

Human Homolog NTRK2, neurotrophic tyrosine kinase, receptor, type 2
NCBI Gene ID 4915
neXtProt AC  NX_Q16620
Human Synonyms  GP145-TrkB, trk-B, TRKB
Human Chr (Location)  9q22.1; chr9:84668502-85027070 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NTRK2
alleles, and
All mutations/alleles(24) : Gene trapped(4) Targeted(20)
Incidental mutations (data from Mutagenetix , APF )
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Ntrk2 interacts with 494 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (100 annotations)
Process brain-derived neurotrophic factor receptor signaling pathway, calcium-mediated signaling using intracellular calcium source, ...
Component axon, axon terminus, ...
Function ATP binding, brain-derived neurotrophic factor-activated receptor activity, ...
External Resources: FuncBase
Literature Summary: (123 records)
Data Summary: Results (313)    Tissues (205)    Images (66)
Theiler Stages: 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 44
RNA in situ 184
Northern blot 42
Western blot 6
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(45) cDNA(28) Primer pair(15) Other(2)
Microarray probesets(11)
Other database
Ensembl Gene ModelENSMUSG00000055254 (Evidence)
Entrez Gene18212 (Evidence)
DFCITC1575671, TC1602361, TC1604716, TC1605566, TC1607816, TC1637892, TC1643845, TC1656841, TC1715426
DoTSDT.101721766, DT.40161626, DT.40185334, DT.60104420, DT.91327786, DT.94300623
NIA Mouse Gene IndexU014925
Consensus CDS ProjectCCDS26573.1, CCDS36685.1
International Mouse Knockout Project StatusNtrk2
Representative SequencesLengthStrain/SpeciesFlank
genomic 18212 NCBI Gene Model | MGI Sequence Detail 323381 C57BL/6J ±  kb
transcript NM_001025074 RefSeq | MGI Sequence Detail 8744 C57BL/6 
polypeptide P15209 UniProt | EBI | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(3090 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3098)
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020777 Tyrosine-protein kinase, neurotrophic receptor
InterPro IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2
InterPro IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology PR:000011470 BDNF/NT-3 growth factors receptor
Graphical View of Protein Domain Structure
References (Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:210382 Aven L, et al., An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb;28(2):897-907
All references(347)
accession IDs
MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory