Ntrk2
Gene Detail

Symbol Name ID

Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 MGI:97384

Synonyms

C030027L06Rik, Tkrb, trkB

Feature Type

protein coding gene

Genetic Map

Chromosome 13

31.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr13:58806596-59129976 bp, + strand From NCBI annotation of GRCm38   323381 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4504  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: high affinity nerve growth factor receptor-like protein kinase
Gene Tree: Ntrk2

Human homologs

Human Homolog		NTRK2, neurotrophic tyrosine kinase, receptor, type 2
NCBI Gene ID		4915
neXtProt AC		NX_Q16620
Human Synonyms		GP145-TrkB, trk-B, TRKB
Human Chr (Location)		9q22.1; chr9:87283466-87638505 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NTRK2

Alleles and phenotypes

All alleles(22) : Targeted(18) Gene trapped(4)
 

Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.

 

Gene Ontology (GO) classifications

All GO classifications: (90 annotations)

Process	brain-derived neurotrophic factor receptor signaling pathway, calcium-mediated signaling using intracellular calcium source, ...
Component	axon, axon terminus, ...
Function	ATP binding, brain-derived neurotrophic factor-activated receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (114 records)
Data Summary: Results (311)    Tissues (198)    Images (64)
Theiler Stages: 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	184
Northern blot	42
Western blot	6
RT-PCR	37

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(28) Primer pair(15) Other(2)
Microarray probesets(11)

Other database links

Ensembl Gene Model	ENSMUSG00000055254 (Evidence)
Entrez Gene	18212 (Evidence)
DFCI	TC1575671, TC1602361, TC1604716, TC1605566, TC1607816, TC1637892, TC1643845, TC1656841, TC1715426
DoTS	DT.101721766, DT.40161626, DT.40185334, DT.60104420, DT.91327786, DT.94300623
NIA Mouse Gene Index	U014925
EC	2.7.10.1
Consensus CDS Project	CCDS26573.1, CCDS36685.1
International Mouse Knockout Project Status	Ntrk2

Sequences

Length	Strain/Species
genomic	18212	NCBI Gene Model | MGI Sequence Detail	323381	C57BL/6J
transcript	NM_008745	RefSeq | MGI Sequence Detail	7022	C57BL/6
polypeptide	P15209	UniProt | EBI | MGI Sequence Detail	821	Not Applicable

All sequences(53) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(2325 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR020777	Tyrosine-protein kinase, neurotrophic receptor
InterPro	IPR020455	Tyrosine-protein kinase, neurotrophic receptor, type 2
InterPro	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Protein Ontology	PR:000011470	BDNF/NT-3 growth factors receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10104 Klein R, et al., trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 1989 Dec 1;8(12):3701-9
(Latest) J:193542 Lai KO, et al., TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15
All references(317)

Other accession IDs

MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299