Ntrk2 MGI Mouse Gene Detail - MGI:97384 - neurotrophic tyrosine kinase, receptor, type 2

Symbol

Ntrk2
Name

neurotrophic tyrosine kinase, receptor, type 2
Synonyms

C030027L06Rik, Tkrb, trkB

Feature Type

protein coding gene
IDs

MGI:97384
NCBI Gene: 18212
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:58954383-59281784 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 31.20 cM
Mapping Data

10 experiments

SNPs within 2kb

3095 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97384	protein coding gene	Chr13:58954286-59281784 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020636	protein coding gene	Chr13:58473190-58811609 (+)
A/J	MGP_AJ_G0020590	protein coding gene	Chr13:56295981-56615263 (+)
AKR/J	MGP_AKRJ_G0020568	protein coding gene	Chr13:57976403-58309050 (+)
BALB/cJ	MGP_BALBcJ_G0020586	protein coding gene	Chr13:56554304-56876124 (+)
C3H/HeJ	MGP_C3HHeJ_G0020385	protein coding gene	Chr13:57771880-58105510 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021020	protein coding gene	Chr13:60250267-60599545 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018602	protein coding gene	Chr13:54188527-54508677 (+)
CAST/EiJ	MGP_CASTEiJ_G0019899	protein coding gene	Chr13:57915862-58269614 (+)
CBA/J	MGP_CBAJ_G0020345	protein coding gene	Chr13:62522904-62879363 (+)
DBA/2J	MGP_DBA2J_G0020468	protein coding gene	Chr13:55841555-56168324 (+)
FVB/NJ	MGP_FVBNJ_G0020447	protein coding gene	Chr13:55327212-55649690 (+)
LP/J	MGP_LPJ_G0020544	protein coding gene	Chr13:58735278-59074297 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020476	protein coding gene	Chr13:61869137-62211224 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021063	protein coding gene	Chr13:57575323-57915824 (+)
PWK/PhJ	MGP_PWKPhJ_G0019655	protein coding gene	Chr13:55857429-56191636 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019482	protein coding gene	Chr13:56477794-56800707 (+)
WSB/EiJ	MGP_WSBEiJ_G0019961	protein coding gene	Chr13:58009870-58358273 (+)

Human Ortholog

NTRK2, neurotrophic receptor tyrosine kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTRK2, neurotrophic receptor tyrosine kinase 2
Synonyms

DEE58, EIEE58, GP145-TrkB, OBHD, trk-B, TRKB
Links

HGNC:8032

NCBI Gene ID: 4915

neXtProt AC: NX_Q16620

UniProt: Q16620
Chr Location

9q21.33; chr9:84668375-85095751 (+) GRCh38

MGI Vertebrate Homology

Ntrk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NTRK2
Gene Tree

Ntrk2

Diseases

5 with human NTRK2 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				autistic disorder IDs autistic disorder DOID:12849 EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 ORDO:106 UMLS_CUI:C0004352
				developmental and epileptic encephalopathy 58 IDs developmental and epileptic encephalopathy 58 DOID:0080285 OMIM:617830
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				morbid obesity IDs morbid obesity DOID:11981 ICD9CM:278.01 MESH:D009767 NCI:C34858 UMLS_CUI:C0028756

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

141 phenotypes from 20 alleles in 27 genetic backgrounds
14 phenotypes from multigenic genotypes
259 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

4
Targeted

25
Genomic Mutations

1 involving Ntrk2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.

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All GO Annotations

133
GO References

44

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1128
Tissues

238
cDNA Data

27
Literature Summary

194

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NTRK2

Xenbase ntrk2

ZFIN ntrk2a

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All Sequences

98
RefSeq

24
UniProt

10
CCDS

CCDS26573.1, CCDS36685.1

Ensembl

ENSMUSG00000055254 (Evidence)
NCBI Gene

18212

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055254	Ensembl Gene Model \| MGI Sequence Detail	327402	C57BL/6J	± kb
transcript	ENSMUST00000079828	Ensembl \| MGI Sequence Detail	8744	Not Applicable
polypeptide	ENSMUSP00000078757	Ensembl \| MGI Sequence Detail	821	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011470 BDNF/NT-3 growth factors receptor

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR020455 BDNF/NT-3 growth factors receptor NTRK2

IPR000483 Cysteine-rich flanking region, C-terminal

IPR020777 Growth factor receptor NTRK

IPR031635 Growth factor receptor NTRK, leucine rich repeat C-terminal

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR002011 Tyrosine-protein kinase, receptor class II, conserved site

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All nucleic 61

cDNA 32

Primer pair 20

Other 9

Microarray probesets 11

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MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299

Summaries

All 580

Developmental Gene Expression 194

Gene Ontology 44

Phenotypes 259
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32

TSS for Ntrk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120082	Chr13:58954378-58954436 (+)	24 bp
Tssr120083	Chr13:58954448-58954469 (+)	76 bp
Tssr120084	Chr13:58955507-58955514 (+)	1,128 bp
Tssr120085	Chr13:58955633-58955652 (+)	1,260 bp
Tssr120086	Chr13:58955675-58955697 (+)	1,303 bp
Tssr120087	Chr13:58955698-58955716 (+)	1,324 bp
Tssr120088	Chr13:58956077-58956100 (+)	1,706 bp
Tssr120089	Chr13:58956497-58956566 (+)	2,149 bp
Tssr120090	Chr13:59054132-59054133 (+)	99,750 bp
Tssr120091	Chr13:59281189-59281193 (+)	326,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23