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Npr2 Gene Detail
Summary
  • Symbol
    Npr2
  • Name
    natriuretic peptide receptor 2
  • Synonyms
    cn, guanylyl cyclase-B, pwe
  • Feature Type
    protein coding gene
  • IDs
    MGI:97372
    NCBI Gene: 230103
  • Gene Overview
    MyGene.info: NPR2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43631935-43651244 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97372
protein coding gene Chr4:43630615-43651437 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028217
protein coding gene Chr4:41765037-41784472 (+)
A/J MGP_AJ_G0028173
protein coding gene Chr4:40274942-40295180 (+)
AKR/J MGP_AKRJ_G0028125
protein coding gene Chr4:41188033-41207412 (+)
BALB/cJ MGP_BALBcJ_G0028193
protein coding gene Chr4:40365905-40385335 (+)
C3H/HeJ MGP_C3HHeJ_G0027915
protein coding gene Chr4:41825850-41845113 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028634
protein coding gene Chr4:43325902-43345209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025946
protein coding gene Chr4:37723289-37742587 (+)
CAST/EiJ MGP_CASTEiJ_G0027355
protein coding gene Chr4:41330768-41352008 (+)
CBA/J MGP_CBAJ_G0027881
protein coding gene Chr4:44651879-44671293 (+)
DBA/2J MGP_DBA2J_G0028030
protein coding gene Chr4:40186290-40205719 (+)
FVB/NJ MGP_FVBNJ_G0027997
protein coding gene Chr4:39410579-39432212 (+)
LP/J MGP_LPJ_G0028129
protein coding gene Chr4:41816603-41835920 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028021
protein coding gene Chr4:47903289-47922581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028670
protein coding gene Chr4:41398740-41418057 (+)
PWK/PhJ MGP_PWKPhJ_G0027081
protein coding gene Chr4:40221780-40241385 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026907
protein coding gene Chr4:40965482-40984905 (+)
WSB/EiJ MGP_WSBEiJ_G0027435
protein coding gene Chr4:41296416-41315802 (+)



Homology
more
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMDM, ANPb, ANPRB, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
  • Links
    NCBI Gene ID: 4882
    neXtProt AC: NX_P20594
    UniProt: P20594

  • Chr Location
    9p13.3; chr9:35752945-35809731 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Npr2 mouse models; 2 with human NPR2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 3 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 11 alleles in 15 genetic backgrounds
    9 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028469 Ensembl Gene Model | MGI Sequence Detail 19310 C57BL/6J ±  kb
    transcript ENSMUST00000030191 Ensembl | MGI Sequence Detail 3660 Not Applicable  
    polypeptide ENSMUSP00000030191 Ensembl | MGI Sequence Detail 1047 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 34
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 8
      Diseases 6
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:5088 Koniukhov BV, et al., Experimental study of the achondroplasia gene effects in the mouse. Acta Biol Acad Sci Hung. 1967;18(3):285-94
    • Latest
      J:255011 Shuhaibar LC, et al., Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. Elife. 2017 Dec 4;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory