About   Help   FAQ
Npr2
Gene Detail
Symbol

Name
ID
Npr2
natriuretic peptide receptor 2
MGI:97372
Synonyms
cn, guanylyl cyclase-B, pwe
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:43631935-43651244 bp, + strand
From VEGA annotation of GRCm38

  19310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

HCOP human homology predictions: NPR2
Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Npr2

Human
homologs
NPR2, natriuretic peptide receptor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4882
neXtProt AC: NX_P20594

Human Synonyms: AMDM, ANPb, ANPRB, ECDM, GUC2B, GUCY2B, NPRB, NPRBi

Human Chr (Location): 9p21-p12; chr9:35752945-35809731 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NPR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Spontaneous(5) Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.
 
Human Diseases Modeled in Mice Using Npr2 (2)    Mutations Annotated to Human Diseases (5)    Phenotype Images(7)
Interactions
Npr2 interacts with 63 markers (Mir34b, Mir34c, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process bone development, cGMP biosynthetic process, ...
Component guanylate cyclase complex, soluble, integral component of membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (149)    Tissues (113)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
RT-PCR 2
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(33) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000007021 (Evidence)
Ensembl Gene Model ENSMUSG00000028469 (Evidence)
Entrez Gene 230103 (Evidence)
UniGene 103477
DFCI TC1583548
DoTS DT.40139099, DT.91281039
NIA Mouse Gene Index U004243
EC 4.6.1.2
Consensus CDS Project CCDS18105.1
International Mouse Phenotyping Consortium Status Npr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007021 VEGA Gene Model | MGI Sequence Detail 19310 C57BL/6J ±  kb
transcript OTTMUST00000016249 VEGA | MGI Sequence Detail 3660 Not Applicable 
polypeptide OTTMUSP00000007443 VEGA | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(5) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR001170 Natriuretic peptide receptor
InterPro IPR029787 Nucleotide cyclase
InterPro IPR028082 Periplasmic binding protein-like I
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001828 Receptor, ligand binding region
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011378 atrial natriuretic peptide receptor 2
References
(Earliest) J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
(Latest) J:222185 Lu CC, et al., Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice. PLoS Genet. 2014 Dec;10(12):e1004823
All references(70)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory