About   Help   FAQ
Npr2
Gene Detail
 Symbol
Name
ID
Npr2
natriuretic peptide receptor 2
MGI:97372
Synonyms cn, guanylyl cyclase-B, pwe
Feature Type protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:43631935-43651244 bp, + strand
From VEGA annotation of GRCm38

  19310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Npr2

Human
homologs
Human Homolog NPR2, natriuretic peptide receptor 2
NCBI Gene ID 4882
neXtProt AC  NX_P20594
Human Synonyms  AMDM, ANPb, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi
Human Chr (Location)  9p21-p12; chr9:35754654-35809731 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NPR2
Alleles
and
phenotypes
All alleles(8) : Spontaneous(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.
 
Human Diseases Modeled Using Mouse Npr2 (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(7)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process bone development, cGMP biosynthetic process, ...
Component integral component of membrane, membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (149)    Tissues (113)    Images (42)
Theiler Stages: 17, 20, 22, 23, 24
Assay TypeResults
RNA in situ 147
RT-PCR 2
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) cDNA(33) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000007021 (Evidence)
Ensembl Gene ModelENSMUSG00000028469 (Evidence)
Entrez Gene230103 (Evidence)
UniGene103477
DFCITC1583548
DoTSDT.40139099, DT.91281039
NIA Mouse Gene IndexU004243
EC4.6.1.2
Consensus CDS ProjectCCDS18105.1
International Mouse Knockout Project StatusNpr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007021 VEGA Gene Model | MGI Sequence Detail 19310 C57BL/6J ±  kb
transcript OTTMUST00000016249 VEGA | MGI Sequence Detail 3660 Not Applicable 
polypeptide OTTMUSP00000007443 VEGA | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(5) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR011645 Haem NO binding associated
InterPro IPR001170 Natriuretic peptide receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011378 atrial natriuretic peptide receptor 2
References (Earliest) J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
(Latest) J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
All references(69)
Other
accession IDs
MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory