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Npr2 Gene Detail
Summary
  • Symbol
    Npr2
  • Name
    natriuretic peptide receptor 2
  • Synonyms
    cn, guanylyl cyclase-B, pwe
  • Feature Type
    protein coding gene
  • IDs
    MGI:97372
    NCBI Gene: 230103
  • Gene Overview
    MyGene.info: NPR2
Location & Maps
more
  • Sequence Map
    Chr4:43631935-43651244 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19310 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NPR2, natriuretic peptide receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMDM, ANPb, ANPRB, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
  • Links
    NCBI Gene ID: 4882
    neXtProt AC: NX_P20594

  • Chr Location
    9p13.3; chr9:35752945-35809731 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Npr2 mouse models; 3 with human NPR2 associations

Human Disease Mouse Models
       Acromesomelic Dysplasia, Maroteaux Type; AMDM   OMIM: 602875 View 2 models
       Achondroplasia; ACH   OMIM: 100800 View 3 models
       Epiphyseal Chondrodysplasia, Miura Type; ECDM   OMIM: 615923
Short Stature with Nonspecific Skeletal Abnormalities; SNSK   OMIM: 616255
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from 11 alleles in 15 genetic backgrounds
    9 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically and radiation induced
    1
  • Spontaneous
    5
  • Targeted
    3
  • Transgenic
    3
  • Genomic Mutations
    2 involving Npr2
  • Incidental Mutations
Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007021 VEGA Gene Model | MGI Sequence Detail 19310 C57BL/6J ±  kb
transcript OTTMUST00000016249 VEGA | MGI Sequence Detail 3660 Not Applicable  
polypeptide OTTMUSP00000007443 VEGA | MGI Sequence Detail 1047 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011378 atrial natriuretic peptide receptor 2
  • EC
  • InterPro Domains
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR001170 Adenylyl cyclase class-4/guanylyl cyclase
    IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
    IPR029787 Nucleotide cyclase
    IPR028082 Periplasmic binding protein-like I
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001828 Receptor, ligand binding region
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 35
    cDNA 33
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430
References
more
  • Summaries
    All 68
    Developmental Gene Expression 8
    Diseases 5
    Gene Ontology 8
    Phenotypes 33
  • Earliest
    J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
  • Latest
    J:228790 Shuhaibar LC, et al., Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Dev Biol. 2016 Jan 1;409(1):194-201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory