Npr2
Gene Detail

Symbol Name ID

Npr2 natriuretic peptide receptor 2 MGI:97372

Synonyms

cn, guanylyl cyclase-B, pwe

Feature Type

protein coding gene

Genetic Map

Chromosome 4

23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:43631935-43651244 bp, + strand From VEGA annotation of GRCm38   19310 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Npr2 ± 2 cM)

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Npr2

Human ortholog

NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) NCBI Gene ID 4882
Human Synonyms: AMDM, ANPb, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi
Human Chr9:35792406-35809728 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NPR2 (1)

Alleles and phenotypes

All alleles(6) : Targeted(1) Spontaneous(5)
 

Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability.

 
Human Diseases Modeled Using Mouse Npr2 (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	bone development, cGMP biosynthetic process, ...
Component	integral to membrane, membrane, ...
Function	ATP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (149)    Tissues (113)    Images (42)
Theiler Stages: 17, 20, 22, 23, 24

Assay Type	Results
RNA in situ	147
RT-PCR	2

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(33) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000007021 (Evidence)
Ensembl Gene Model	ENSMUSG00000028469 (Evidence)
Entrez Gene	230103 (Evidence)
UniGene	103477
DFCI	TC1583548
DoTS	DT.40139099, DT.91281039
NIA Mouse Gene Index	U004243
EC	4.6.1.2
Consensus CDS Project	CCDS18105.1
International Mouse Knockout Project Status	Npr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007021	VEGA Gene Model | MGI Sequence Detail	19310	C57BL/6J
transcript	OTTMUST00000016249	VEGA | MGI Sequence Detail	3660	Not Applicable
polypeptide	OTTMUSP00000007443	VEGA | MGI Sequence Detail	1047	Not Applicable

All sequences(55) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR011645	Haem NO binding associated
InterPro	IPR001170	Natriuretic peptide receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000011378	atrial natriuretic peptide receptor B

References

(Earliest) J:26341 Dickie MM, New mutant - achondroplasia - cn. Mouse News Lett. 1960;23:34
(Latest) J:192266 Sogawa C, et al., C-type natriuretic peptide specifically acts on the pylorus and large intestine in mouse gastrointestinal tract. Am J Pathol. 2013 Jan;182(1):172-9
All references(67)

Other accession IDs

MGD-MRK-12926, MGD-MRK-2032, MGI:1933832, MGI:88430