Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Involved in several processes, including reproductive structure development; skeletal system development; and vasculature development. Acts upstream of or within several processes, including cGMP biosynthetic process; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Is active in several cellular components, including cilium; neuron projection; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study achondroplasia and acromesomelic dysplasia, Maroteaux type. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2).
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