GO Annotations Graph

• Symbol: Npr2
• Name: natriuretic peptide receptor 2
• ID: MGI:97372

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0004383	guanylate cyclase activity	ISO	J:164563
Molecular Function	GO:0004383	guanylate cyclase activity	IBA	J:265628
Molecular Function	GO:0004383	guanylate cyclase activity	IDA	J:228790
Molecular Function	GO:0004383	guanylate cyclase activity	IDA	J:255011
Molecular Function	GO:0004383	guanylate cyclase activity	IDA	J:86794
Molecular Function	GO:0042562	hormone binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:86794
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0016941	natriuretic peptide receptor activity	ISO	J:164563
Molecular Function	GO:0016941	natriuretic peptide receptor activity	IBA	J:265628
Molecular Function	GO:0016941	natriuretic peptide receptor activity	IDA	J:86794
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0017046	peptide hormone binding	IBA	J:265628
Molecular Function	GO:0016849	phosphorus-oxygen lyase activity	IEA	J:72247
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Cellular Component	GO:0005929	cilium	IDA	J:275270
Cellular Component	GO:0005737	cytoplasm	IDA	J:192266
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IDA	J:192266
Cellular Component	GO:0005634	nucleus	IDA	J:192266
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:86794
Biological Process	GO:0060466	activation of meiosis involved in egg activation	IMP	J:188839
Biological Process	GO:0060466	activation of meiosis involved in egg activation	IMP	J:190645
Biological Process	GO:0060466	activation of meiosis involved in egg activation	IMP	J:228790
Biological Process	GO:0007409	axonogenesis	IMP	J:135081
Biological Process	GO:0007409	axonogenesis	IMP	J:267448
Biological Process	GO:0060385	axonogenesis involved in innervation	IMP	J:222185
Biological Process	GO:0008015	blood circulation	IMP	J:296148
Biological Process	GO:0001568	blood vessel development	IMP	J:296148
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:304153
Biological Process	GO:0060348	bone development	IMP	J:5934
Biological Process	GO:0098868	bone growth	IMP	J:188839
Biological Process	GO:0098868	bone growth	IMP	J:255011
Biological Process	GO:0098868	bone growth	IMP	J:267448
Biological Process	GO:0061939	c-di-GMP signaling	IMP	J:163374
Biological Process	GO:0061939	c-di-GMP signaling	IMP	J:192266
Biological Process	GO:0051216	cartilage development	IMP	J:98753
Biological Process	GO:0051216	cartilage development	IMP	J:129973
Biological Process	GO:0071321	cellular response to cGMP	IMP	J:228790
Biological Process	GO:1901653	cellular response to peptide	IMP	J:275270
Biological Process	GO:0006182	cGMP biosynthetic process	ISO	J:164563
Biological Process	GO:0006182	cGMP biosynthetic process	IBA	J:265628
Biological Process	GO:0046068	cGMP metabolic process	IMP	J:98753
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:135081
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:129973
Biological Process	GO:0035988	chondrocyte proliferation	IMP	J:129973
Biological Process	GO:0051276	chromosome organization	IMP	J:191608
Biological Process	GO:0048668	collateral sprouting	IMP	J:135081
Biological Process	GO:0048668	collateral sprouting	IMP	J:205571
Biological Process	GO:0048668	collateral sprouting	IMP	J:222185
Biological Process	GO:0001549	cumulus cell differentiation	IMP	J:191608
Biological Process	GO:0009190	cyclic nucleotide biosynthetic process	IEA	J:72247
Biological Process	GO:0048565	digestive tract development	IMP	J:296148
Biological Process	GO:0048546	digestive tract morphogenesis	IMP	J:163374
Biological Process	GO:0001958	endochondral ossification	IMP	J:94718
Biological Process	GO:0001958	endochondral ossification	IMP	J:98753
Biological Process	GO:0001958	endochondral ossification	IMP	J:129973
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:190645
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:228790
Biological Process	GO:0097194	execution phase of apoptosis	IMP	J:211104
Biological Process	GO:0030540	female genitalia development	IMP	J:94718
Biological Process	GO:0035483	gastric emptying	IMP	J:192266
Biological Process	GO:0035112	genitalia morphogenesis	IMP	J:211104
Biological Process	GO:0007281	germ cell development	IMP	J:211104
Biological Process	GO:0003417	growth plate cartilage development	IMP	J:129973
Biological Process	GO:0003417	growth plate cartilage development	IMP	J:188839
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0060173	limb development	IMP	J:94718
Biological Process	GO:0035108	limb morphogenesis	IMP	J:129973
Biological Process	GO:0001945	lymph vessel development	IMP	J:296148
Biological Process	GO:0000165	MAPK cascade	IMP	J:188839
Biological Process	GO:0051321	meiotic cell cycle	IMP	J:164870
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	IMP	J:190645
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	IMP	J:191608
Biological Process	GO:0035264	multicellular organism growth	IMP	J:94718
Biological Process	GO:0035264	multicellular organism growth	IMP	J:98753
Biological Process	GO:0035264	multicellular organism growth	IMP	J:129973
Biological Process	GO:0035264	multicellular organism growth	IMP	J:188839
Biological Process	GO:0035264	multicellular organism growth	IMP	J:267448
Biological Process	GO:0032504	multicellular organism reproduction	IMP	J:188839
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	IMP	J:164870
Biological Process	GO:1900194	negative regulation of oocyte maturation	IMP	J:164870
Biological Process	GO:0021675	nerve development	IMP	J:296148
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:269662
Biological Process	GO:0019228	neuronal action potential	IMP	J:222185
Biological Process	GO:0048599	oocyte development	IMP	J:191608
Biological Process	GO:0001503	ossification	IEA	J:60000
Biological Process	GO:0001541	ovarian follicle development	IMP	J:191608
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	ISO	J:155856
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:129973
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	ISO	J:164563
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	IBA	J:265628
Biological Process	GO:0072001	renal system development	IMP	J:282117
Biological Process	GO:0022414	reproductive process	IMP	J:164870
Biological Process	GO:0071774	response to fibroblast growth factor	IMP	J:255011
Biological Process	GO:0009725	response to hormone	IMP	J:163374
Biological Process	GO:0034699	response to luteinizing hormone	IMP	J:228790
Biological Process	GO:1902074	response to salt	IMP	J:282117
Biological Process	GO:0009611	response to wounding	IMP	J:282117
Biological Process	GO:0007605	sensory perception of sound	IMP	J:278320
Biological Process	GO:0007338	single fertilization	IMP	J:188839
Biological Process	GO:0007338	single fertilization	IMP	J:191608
Biological Process	GO:0007338	single fertilization	IMP	J:275270
Biological Process	GO:0048745	smooth muscle tissue development	IMP	J:296148
Biological Process	GO:0007283	spermatogenesis	IMP	J:211104
Biological Process	GO:0001964	startle response	IMP	J:278320
Biological Process	GO:0007033	vacuole organization	IMP	J:211104
Biological Process	GO:0061042	vascular wound healing	IMP	J:304153
Biological Process	GO:0001570	vasculogenesis	IMP	J:304153
Biological Process	GO:0021562	vestibulocochlear nerve development	IMP	J:278320
Biological Process	GO:0021562	vestibulocochlear nerve development	IMP	J:278320
Biological Process	GO:0021647	vestibulocochlear nerve maturation	IMP	J:222185
Biological Process	GO:0050872	white fat cell differentiation	IMP	J:296148