Phenotypes Associated with This Genotype

Genotype
MGI:3828048

• Allelic Composition: Npr2^cn/Npr2^cn
• Genetic Background: involves: AKR/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:153212 )

• a small percentage of sensory axons extend directly towards the central canal unlike in wild-type mice

abnormal spinal cord dorsal column morphology ( J:153212 )

• the dorsal funiculus is reduced in size compared to in wild-type mice

skeleton

abnormal skeleton development ( J:5934 )

• growth of femora and tibiae is sub-normal in pre-wean homozygotes and growth is severely interupted at weaning, between 21 and 28 days of age, before resuming slow growth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achondroplasia		DOID:4480	OMIM:100800	J:26341