About Help FAQ

Symbol
Name
ID

Npr2
natriuretic peptide receptor 2
MGI:97372

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Frontal bossing

Dolichocephaly

Bowing of the long bones

Radial bowing

Fifth finger distal phalanx clinodactyly

Cone-shaped epiphyses of the phalanges of the hand

Short phalanx of finger

Broad finger

Arachnodactyly

Broad hallux

Long hallux

Short toe

Broad phalanx

Brachydactyly

Short metatarsal

Broad metatarsal

Flared metaphysis

Hypoplasia of the radius

Short metacarpal

Broad metacarpals

Limited elbow extension

Acromesomelia

Joint hypermobility

Joint stiffness

Epiphyseal dysplasia

Sprengel anomaly

Lower thoracic kyphosis

Thoracolumbar kyphosis

Hyperlordosis

Lumbar hyperlordosis

Kyphosis

Scoliosis

Abnormal form of the vertebral bodies

Beaking of vertebral bodies

Ovoid vertebral bodies

Thoracolumbar interpediculate narrowness

Vertebral wedging

Osteopenia

Disease(s) Associated with NPR2

acromesomelic dysplasia, Maroteaux type

Miura type epiphyseal chondrodysplasia

Mouse Phenotypes

skeleton phenotype

abnormal cranium morphology

abnormal basicranium morphology

decreased cranium length

decreased cranium width

abnormal neurocranium morphology

enlarged interparietal bone

small supraoccipital bone

enlarged parietal bone

long lower incisors

long upper incisors

long incisors

malocclusion

abnormal mandibular condyloid process morphology

short maxilla

small nasal bone

domed cranium

abnormal phalanx morphology

short humerus

short radius

short ulna

short femur

increased diameter of femur

long femur

long tibia

short tibia

abnormal long bone morphology

abnormal long bone epiphyseal plate morphology

abnormal long bone epiphyseal plate proliferative zone

abnormal long bone hypertrophic chondrocyte zone

decreased width of hypertrophic chondrocyte zone

decreased long bone epiphyseal plate size

disorganized long bone epiphyseal plate

increased long bone epiphyseal plate size

decreased length of long bones

short scapula

abnormal pelvic girdle bone morphology

abnormal axial skeleton morphology

splayed ribs

kyphosis

abnormal vertebrae morphology

short vertebral column

abnormal bone trabecula morphology

abnormal chondrocyte morphology

abnormal skeleton development

chondrodystrophy

abnormal endochondral bone ossification

Availability

Mouse Genotype

Npr2^cn-2J/Npr2^cn-2J

*

Npr2^cn/Npr2^cn

!

Npr2^slw/Npr2^slw

Npr2^tm1Gar/Npr2^tm1Gar

Tg(Col11a2-Npr2*)28Keoz/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23