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Nos3 Gene Detail
Summary
  • Symbol
    Nos3
  • Name
    nitric oxide synthase 3, endothelial cell
  • Synonyms
    2310065A03Rik, ecNOS, eNOS, Nos-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97362
    NCBI Gene: 18127
  • Gene Overview
    MyGene.info: NOS3
Location & Maps
more
  • Sequence Map
    Chr5:24364810-24384474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19665 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NOS3, nitric oxide synthase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NOS3, nitric oxide synthase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ECNOS, eNOS
  • Links
    NCBI Gene ID: 4846
    neXtProt AC: NX_P29474

  • Chr Location
    7q36; chr7:150991056-151014599 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Nos3 mouse models; 5 with human NOS3 associations

Human Disease Mouse Models
       Hypertension, Essential   OMIM: 145500 View 3 models
       Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins;   OMIM: 265380 View 1 model
       Alzheimer Disease; AD   OMIM: 104300
Nitric Oxide Synthase 3; NOS3   OMIM: 163729
Preeclampsia/Eclampsia 1; PEE1   OMIM: 189800
Stroke, Ischemic   OMIM: 601367
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    216 phenotypes from 9 alleles in 17 genetic backgrounds
    95 phenotypes from multigenic genotypes
    1 images
    485 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    4 involving Nos3
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit reduced survival, hypertension, inhibited basal vasodilation, insulin resistance, fewer mitochondria, reduced heart rate, impaired ovulation and, in some, shortened limbs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024082 VEGA Gene Model | MGI Sequence Detail 19665 C57BL/6J ±  kb
transcript OTTMUST00000058885 VEGA | MGI Sequence Detail 4132 Not Applicable  
polypeptide OTTMUSP00000028591 VEGA | MGI Sequence Detail 1202 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    159 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011328 nitric oxide synthase, endothelial
  • EC
  • InterPro Domains
    IPR003097 FAD-binding, type 1
    IPR017927 Ferredoxin reductase-type FAD-binding domain
    IPR001094 Flavodoxin-like
    IPR008254 Flavodoxin/nitric oxide synthase
    IPR029039 Flavoprotein-like domain
    IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
    IPR012144 Nitric-oxide synthase, eukaryote
    IPR004030 Nitric oxide synthase, N-terminal
    IPR001433 Oxidoreductase FAD/NAD(P)-binding
    IPR017938 Riboflavin synthase-like beta-barrel
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 13
    Primer pair 7

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12911, MGD-MRK-12914, MGI:1919183
References
more
  • Summaries
    All 617
    Developmental Gene Expression 43
    Diseases 9
    Gene Ontology 14
    Phenotypes 485
  • Earliest
    J:19282 O'Dell TJ, et al., Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science. 1994 Jul 22;265(5171):542-6
  • Latest
    J:228744 Meesters DM, et al., Deficiency of inducible and endothelial nitric oxide synthase results in diminished bone formation and delayed union and nonunion development. Bone. 2016 Feb;83:111-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory