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Nos3 Gene Detail
Summary
  • Symbol
    Nos3
  • Name
    nitric oxide synthase 3, endothelial cell
  • Synonyms
    2310065A03Rik, ecNOS, eNOS, Nos-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97362
    NCBI Gene: 18127
  • Gene Overview
    MyGene.info: NOS3
Location & Maps
more
  • Sequence Map
    Chr5:24364810-24384474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 11.32 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    NOS3, nitric oxide synthase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NOS3, nitric oxide synthase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECNOS, eNOS
  • Links
    NCBI Gene ID: 4846
    neXtProt AC: NX_P29474
    UniProt: P29474

  • Chr Location
    7q36.1; chr7:150991056-151014599 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Nos3 mouse models; 4 with human NOS3 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    216 phenotypes from 9 alleles in 17 genetic backgrounds
    95 phenotypes from multigenic genotypes
    1 images
    492 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    3
  • Genomic Mutations
    4 involving Nos3
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygotes for targeted null mutations exhibit reduced survival, hypertension, inhibited basal vasodilation, insulin resistance, fewer mitochondria, reduced heart rate, impaired ovulation and, in some, shortened limbs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024082 VEGA Gene Model | MGI Sequence Detail 19665 C57BL/6J ±  kb
transcript OTTMUST00000058885 VEGA | MGI Sequence Detail 4132 Not Applicable  
polypeptide OTTMUSP00000028591 VEGA | MGI Sequence Detail 1202 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    159 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 13
    Primer pair 7

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12911, MGD-MRK-12914, MGI:1919183
References
more
  • Summaries
    All 650
    Developmental Gene Expression 45
    Diseases 9
    Gene Ontology 14
    Phenotypes 492
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:239252 Zhang T, et al., Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Hum Mol Genet. 2016 Aug 13;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory