About   Help   FAQ
Nos3 Gene Detail
Summary
  • Symbol
    Nos3
  • Name
    nitric oxide synthase 3, endothelial cell
  • Synonyms
    2310065A03Rik, ecNOS, eNOS, Nos-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97362
    NCBI Gene: 18127
  • Gene Overview
    MyGene.info: NOS3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24364819-24384474 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 11.32 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97362
protein coding gene Chr5:24364810-24384474 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029338
protein coding gene Chr5:22087433-22107727 (+)
A/J MGP_AJ_G0029304
protein coding gene Chr5:21334984-21356225 (+)
AKR/J MGP_AKRJ_G0029255
protein coding gene Chr5:22197880-22217531 (+)
BALB/cJ MGP_BALBcJ_G0029315
protein coding gene Chr5:21850620-21870260 (+)
C3H/HeJ MGP_C3HHeJ_G0029035
protein coding gene Chr5:22310300-22329921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029768
protein coding gene Chr5:23569897-23602450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027006
protein coding gene Chr5:19279784-19299654 (+)
CAST/EiJ MGP_CASTEiJ_G0028447
protein coding gene Chr5:21482289-21503534 (+)
CBA/J MGP_CBAJ_G0029002
protein coding gene Chr5:23952775-23977009 (+)
DBA/2J MGP_DBA2J_G0029153
protein coding gene Chr5:21630987-21650408 (+)
FVB/NJ MGP_FVBNJ_G0029111
protein coding gene Chr5:20998096-21018976 (+)
LP/J MGP_LPJ_G0029237
protein coding gene Chr5:22486367-22505902 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029140
protein coding gene Chr5:25091768-25111390 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029802
protein coding gene Chr5:21835699-21856656 (+)
PWK/PhJ MGP_PWKPhJ_G0028171
protein coding gene Chr5:20708224-20728044 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028002
protein coding gene Chr5:21192570-21215049 (+)
WSB/EiJ MGP_WSBEiJ_G0028527
protein coding gene Chr5:21903990-21923565 (+)



Homology
more
  • Human Ortholog
    NOS3, nitric oxide synthase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NOS3, nitric oxide synthase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECNOS, eNOS
  • Links
    NCBI Gene ID: 4846
    neXtProt AC: NX_P29474
    UniProt: P29474

  • Chr Location
    7q36.1; chr7:150991056-151014599 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Nos3 mouse models; 3 with human NOS3 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    216 phenotypes from 9 alleles in 17 genetic backgrounds
    95 phenotypes from multigenic genotypes
    1 images
    525 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced survival, hypertension, inhibited basal vasodilation, insulin resistance, fewer mitochondria, reduced heart rate, impaired ovulation and, in some, shortened limbs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18127 NCBI Gene Model | MGI Sequence Detail 19656 C57BL/6J ±  kb
    transcript NM_008713 RefSeq | MGI Sequence Detail 4140 C57BL/6  
    polypeptide P70313 UniProt | EBI | MGI Sequence Detail 1202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011328 nitric oxide synthase, endothelial
    • EC
    • InterPro Domains
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR001094 Flavodoxin-like
      IPR008254 Flavodoxin/nitric oxide synthase
      IPR029039 Flavoprotein-like superfamily
      IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
      IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
      IPR012144 Nitric-oxide synthase, eukaryote
      IPR004030 Nitric oxide synthase, N-terminal
      IPR036119 Nitric oxide synthase, N-terminal domain superfamily
      IPR001433 Oxidoreductase FAD/NAD(P)-binding
      IPR017938 Riboflavin synthase-like beta-barrel
      IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 14
      Primer pair 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12911, MGD-MRK-12914, MGI:1919183
    References
    more
    • Summaries
      All 754
      Developmental Gene Expression 54
      Diseases 9
      Gene Ontology 18
      Phenotypes 525
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:266225 Sogawa Y, et al., The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice. PLoS One. 2018;13(10):e0203823

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory