88 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apoetm1Unc/Apoetm1Unc Nos3tm1Plh/Nos3tm1Plh B6.129-Nos3tm1Plh Apoetm1Unc	aortic dissection	J:103306
	cardiac fibrosis	J:103306
	decreased cardiac muscle contractility	J:103306
	dilated heart left ventricle	J:103306
	increased heart left ventricle posterior wall thickness	J:103306
	increased mean systemic arterial blood pressure	J:103306
	increased susceptibility to atherosclerosis	J:103306
	increased susceptibility to induced aneurysm formation	J:103306
	thick interventricular septum	J:103306
Apoetm1Unc/Apoetm1Unc Nos3tm1Unc/Nos3tm1Unc B6.129P2-Nos3tm1Unc Apoetm1Unc	abnormal cardiovascular system morphology	J:60670
	abnormal renal glomerulus morphology	J:60670
	aortic sinus aneurysm	J:60670
	atherosclerotic lesions	J:60670
	decreased kidney weight	J:60670
	increased circulating creatinine level	J:60670
	increased susceptibility to atherosclerosis	J:60670
	increased systemic arterial systolic blood pressure	J:60670
Asltm1Brle/Asl+ Nos3tm1Weo/Nos3+ involves: 129S7/SvEvBrd	decreased systemic arterial diastolic blood pressure	J:180208
	decreased systemic arterial systolic blood pressure	J:180208
Leprdb/Leprdb Nos3tm1Unc/Nos3tm1Unc BKS.Cg-Leprdb Nos3tm1Unc	abnormal kidney afferent arteriole morphology	J:135864
	abnormal nephron morphology	J:135864
	abnormal renal glomerulus morphology	J:135864
	albuminuria	J:135864
	decreased renal glomerular filtration rate	J:135864
	expanded mesangial matrix	J:135864
	glomerulosclerosis	J:135864
	hyperglycemia	J:135864
	increased body weight	J:135864
	increased circulating creatinine level	J:135864
	increased renal glomerulus basement membrane thickness	J:135864
	increased systemic arterial systolic blood pressure	J:135864
	mesangiolysis	J:135864
	renal glomerulus fibrosis	J:135864
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd	abnormal bone mineralization	J:150159
	abnormal bone structure	J:150159
	abnormal coronary artery morphology	J:100308
	abnormal glomerular capillary thrombosis	J:100308
	abnormal kidney physiology	J:100308
	abnormal nitric oxide homeostasis	J:100308
	abnormal osteoclast physiology	J:150159
	abnormal renal glomerulus morphology	J:100308
	abnormal skeleton physiology	J:150159
	abnormal trabecular bone morphology	J:150159
	congestive heart failure	J:100308
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	dehydration	J:100308
	enlarged stomach	J:100308
	glomerulosclerosis	J:100308
	hypertension	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased bone mineral density	J:150159
	increased circulating alkaline phosphatase level	J:150159
	increased circulating creatinine level	J:100308
	increased osteoclast cell number	J:150159
	increased prostaglandin level	J:100308
	increased renal tubule apoptosis	J:100308
	increased systemic arterial blood pressure	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	liver vascular congestion	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	pulmonary vascular congestion	J:100308
	pyloric sphincter hypertrophy	J:100308
	reduced fertility	J:100308
	renal tubular necrosis	J:100308
	visceral vascular congestion	J:100308
Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system morphology	J:155090
	abnormal cardiovascular system physiology	J:155090
	abnormal circulating glucose level	J:155090
	abnormal vascular endothelial cell physiology	J:155090
	abnormal vascular wound healing	J:155090
	arteriosclerosis	J:155090
	decreased adiponectin level	J:155090
	hypertension	J:155090
	increased circulating LDL cholesterol level	J:155090
	increased circulating triglyceride level	J:155090
	increased white adipose tissue amount	J:155090
	perivascular fibrosis	J:155090
	premature death	J:155090
	thick ventricular wall	J:155090
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh B6.129S4-Nos3tm1Plh Nos1tm1Plh	abnormal cardiac muscle relaxation	J:129064
	cardiac interstitial fibrosis	J:129064
	decreased left ventricle diastolic pressure	J:129064
	heart left ventricle hypertrophy	J:129064
	increased cardiac muscle contractility	J:129064
	increased heart rate	J:129064
	increased systemic arterial systolic blood pressure	J:129064
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae	abnormal sensory neuron innervation pattern	J:61144
	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	normal nervous system phenotype	J:37956
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
	reduced long-term potentiation	J:37956
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * C57BL/6	abnormal cardiac muscle relaxation	J:75645
	decreased cardiac muscle contractility	J:75645
	decreased survivor rate	J:129064
	heart left ventricle hypertrophy	J:75645
	increased cardiac muscle contractility	J:75645
	increased heart rate	J:75645
	increased systemic arterial systolic blood pressure	J:75645
	premature death	J:129064
Nos1tm1Plh/Nos1tm1Plh Nos3tm1Unc/Nos3tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	prenatal lethality, incomplete penetrance	J:83112
Nos2tm1Lau/Nos2tm1Lau Nos3tm1Unc/Nos3tm1Unc B6.129P2-Nos3tm1Unc Nos2tm1Lau	prenatal lethality, incomplete penetrance	J:83112
Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh involves: 129S4/SvJae * 129S7/SvEvBrd	decreased heart rate	J:100308
	decreased survivor rate	J:100308
	decreased urine osmolality	J:100308
	decreased urine sodium level	J:100308
	increased blood osmolality	J:100308
	increased blood urea nitrogen level	J:100308
	increased systemic arterial systolic blood pressure	J:100308
	polydipsia	J:100308
	polyuria	J:100308
	premature death	J:100308
	reduced fertility	J:100308
Nos3tm1Plh/Nos3tm1Plh Ptgs1tm1Unc/Ptgs1tm1Unc involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal blood vessel physiology	J:108540
	decreased physiological sensitivity to xenobiotic	J:108540
	decreased prostaglandin level	J:108540
	increased systemic arterial systolic blood pressure	J:108540
Nos3tm1Plh/Nos3tm1Plh Tg(RHO-VEGFA)V-6Camp/0 involves: 129S4/SvJae * C57BL/6J	abnormal angiogenesis	J:106207