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Targeted Allele Detail
Symbol: Nos2tm1Lau
Name: nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach
MGI ID: MGI:1857228
Synonyms: iNOS-, iNOS-, iNOS KO, NOS2-, Nos2tm1Lau, NOS2tm/Lau
Gene: Nos2  Location: Chr11:78811613-78851052 bp, + strand  Genetic Position: Chr11, 46.74 cM
Alliance: Nos2tm1Lau page
Germline Transmission:  Earliest citation of germline transmission: J:29677
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. (J:29677, J:183641)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 23 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Nos2tm1Lau
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation:  42 strains or lines available
Original:  J:29677 Laubach VE, et al., Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10688-92
All:  476 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory