|
Symbol Name ID |
Nos3
nitric oxide synthase 3, endothelial cell MGI:97362 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Unconjugated hyperbilirubinemia |
Increased LDL cholesterol concentration |
Hypercholesterolemia |
Hypertriglyceridemia |
Elevated circulating creatinine concentration |
Elevated circulating hepatic transaminase concentration |
Increased circulating lactate dehydrogenase concentration |
Glucose intolerance |
Diabetes mellitus |
Type II diabetes mellitus |
Impaired glucose tolerance |
Elevated sweat chloride |
Dehydration |
Hypercalciuria |
Hematuria |
Decreased level of D-mannose in urine |
| Disease(s) Associated with NOS3 | ||||||||||||||||
| Behcet's disease | ||||||||||||||||
| coronary artery disease | ||||||||||||||||
| cystic fibrosis | ||||||||||||||||
| sickle cell anemia |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal vascular wound healing |
increased susceptibility to neuronal excitotoxicity |
abnormal blood homeostasis |
increased blood urea nitrogen level |
abnormal circulating glucose level |
decreased fasting circulating glucose level |
decreased circulating glucose level |
increased circulating glucose level |
increased circulating estradiol level |
decreased circulating insulin level |
increased circulating insulin level |
increased circulating leptin level |
increased circulating osteocalcin level |
increased circulating progesterone level |
increased circulating LDL cholesterol level |
increased circulating cholesterol level |
increased circulating free fatty acids level |
increased circulating triglyceride level |
hyperlipidemia |
decreased circulating phosphate level |
abnormal circulating protein level |
increased circulating creatine kinase level |
increased circulating renin level |
abnormal glomerular capillary thrombosis |
cyanosis |
decreased body temperature |
abnormal dopamine level |
pulmonary alveolar edema |
abnormal glucose homeostasis |
improved glucose tolerance |
insulin resistance |
decreased adiponectin level |
abnormal serotonin level |
decreased prostaglandin level |
albuminuria |
abnormal response/metabolism to endogenous compounds |
decreased physiological sensitivity to xenobiotic |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Nos3em1(IMPC)Mbp/Nos3em1(IMPC)Mbp | |||||||||||||||||||||||||||||||||||||||
| Nos3tm1.2Taka/Nos3tm1.2Taka | |||||||||||||||||||||||||||||||||||||||
| Nos3tm1Gdk/Nos3tm1Gdk | |||||||||||||||||||||||||||||||||||||||
| Nos3tm1Plh/Nos3tm1Plh | * | ||||||||||||||||||||||||||||||||||||||
| Nos3tm1Unc/Nos3tm1Unc | * | ||||||||||||||||||||||||||||||||||||||
| Nos3tm2.1Plh/Nos3tm2.1Plh | |||||||||||||||||||||||||||||||||||||||
| Nos3tm3.1Plh/Nos3tm3.1Plh | |||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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