Nfkb1
Gene Detail

Symbol

Name
ID

Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312

Synonyms

NF-kappaB, NF kappaB1, NF-kappaB p50, nuclear factor kappaB p50, p50, p50/p105, p50 subunit of NF kappaB

Feature Type

protein coding gene

Genetic Map

Chromosome 3
62.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr3:135584655-135691547 bp, - strand From VEGA annotation of GRCm38   106893 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb1

Human
homologs

Human Homolog		NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NCBI Gene ID		4790
neXtProt AC		NX_P19838
Human Synonyms		EBP-1, KBF1, NFkappaB, NF-kappaB, NF-kappa-B, NF-kB1, NFKB-p105, NFKB-p50, p105, p50
Human Chr (Location)		4q24; chr4:102501329-102617302 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(80) : Chemically induced (ENU)(1) Gene trapped(74) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice have a decreased survivor rate, abnormal T cell development and decreased number of peripheral T cells, abnormal humoral responses with decreased immunoglobulin class switching, exhibit mild organ inflammation, and are susceptible to both bacterial infections and hearing loss.

 

Interactions

Nfkb1 interacts with 139 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (71 annotations)

Process	apoptotic process, cellular response to interleukin-6, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)

Data Summary: Results (234)    Tissues (196)    Images (35)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	184
RT-PCR	50

cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(120) cDNA(117) Primer pair(3)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016668 (Evidence)
Ensembl Gene Model	ENSMUSG00000028163 (Evidence)
Entrez Gene	18033 (Evidence)
UniGene	256765
DFCI	TC1575839, TC1589850, TC1604939, TC1610242, TC1660191
DoTS	DT.101143716, DT.101326875, DT.87055129, DT.91419108, DT.91427614, DT.91573435, DT.94183786, DT.94250067
NIA Mouse Gene Index	U024684
PDB	1BFS, 1IKN, 1LEI, 1NFK, 1OOA, 1U3J, 1U3Y, 1U3Z, 1VKX, 2I9T, 2V2T, 1LE5, 1LE9, 1U36, 1U41, 1U42, 3JV4
Consensus CDS Project	CCDS17858.1
International Mouse Knockout Project Status	Nfkb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016668	VEGA Gene Model | MGI Sequence Detail	106893	C57BL/6J
transcript	OTTMUST00000040338	VEGA | MGI Sequence Detail	4117	Not Applicable
polypeptide	OTTMUSP00000018024	VEGA | MGI Sequence Detail	971	Not Applicable

All sequences(76) RefSeq(8) UniProt(7)

Polymorphisms

RFLP(1) : SNPs within 2kb(840 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR002909	Cell surface receptor IPT/TIG
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000451	NF-kappa-B/Rel/Dorsal
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR011539	Rel homology domain
Protein Ontology	PR:000001754	nuclear factor NF-kappa-B p105 subunit

References

(Earliest) J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
(Latest) J:216064 Tartey S, et al., Akirin2 is critical for inducing inflammatory genes by bridging IkappaB-zeta and the SWI/SNF complex. EMBO J. 2014 Oct 16;33(20):2332-48
All references(436)

Other
accession IDs

MGD-MRK-12829