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Nfkb1
Gene Detail
Symbol

Name
ID
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312
Synonyms
NF-kappaB, NF kappaB1, NF-kappaB p50, nuclear factor kappaB p50, p50, p50/p105, p50 subunit of NF kappaB
Feature Type
protein coding gene
Genetic Map
Chromosome 3
62.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr3:135584655-135691547 bp, - strand
From VEGA annotation of GRCm38

  106893 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NFKB1
Protein SuperFamily: transcription factor NF-kappa-B2
Gene Tree: Nfkb1

Human
homologs
NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4790
neXtProt AC: NX_P19838

Human Synonyms: EBP-1, KBF1, NFkappaB, NF-kappaB, NF-kappa-B, NF-kB1, NFKB-p105, NFKB-p50, p105, p50

Human Chr (Location): 4q24; chr4:102501329-102617302 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Chemically induced (ENU)(1) Gene trapped(74) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice have a decreased survivor rate, abnormal T cell development and decreased number of peripheral T cells, abnormal humoral responses with decreased immunoglobulin class switching, exhibit mild organ inflammation, and are susceptible to both bacterial infections and hearing loss.
 
Interactions
Nfkb1 interacts with 139 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process apoptotic process, cellular response to brain-derived neurotrophic factor stimulus, ...
Component cytoplasm, cytosol, ...
Function actinin binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (234)    Tissues (196)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 184
RT-PCR 50
cDNA source data(116)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfkb1    NEW 
Molecular
reagents
All nucleic(120) cDNA(117) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016668 (Evidence)
Ensembl Gene Model ENSMUSG00000028163 (Evidence)
Entrez Gene 18033 (Evidence)
UniGene 256765
DFCI TC1575839, TC1589850, TC1604939, TC1610242, TC1660191
DoTS DT.101143716, DT.101326875, DT.87055129, DT.91419108, DT.91427614, DT.91573435, DT.94183786, DT.94250067
NIA Mouse Gene Index U024684
PDB 1BFS, 1IKN, 1LE5, 1LE9, 1LEI, 1NFK, 1OOA, 1U36, 1U3J, 1U3Y, 1U3Z, 1U41, 1U42, 1VKX, 2I9T, 2V2T, 3JV4
Consensus CDS Project CCDS17858.1
International Mouse Phenotyping Consortium Status Nfkb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016668 VEGA Gene Model | MGI Sequence Detail 106893 C57BL/6J ±  kb
transcript OTTMUST00000040338 VEGA | MGI Sequence Detail 4117 Not Applicable 
polypeptide OTTMUSP00000018024 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(840 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000451 NF-kappa-B/Rel/Dorsal
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000001754 nuclear factor NF-kappa-B p105 subunit
References
(Earliest) J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
(Latest) J:222748 Burkitt MD, et al., NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. J Pathol. 2015 Jul;236(3):326-36
All references(445)
Other
accession IDs
MGD-MRK-12829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory