Nfkb1 MGI Mouse Gene Detail - MGI:97312 - nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Nfkb1 Gene Detail

Symbol

Nfkb1
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms

NF-kappaB, NF kappaB1, NF-kappaB p50, nuclear factor kappaB p50, p50, p50/p105, p50 subunit of NF kappaB

Feature Type

protein coding gene
IDs

MGI:97312
NCBI Gene: 18033
Gene Overview

MyGene.info: NFKB1

Sequence Map

Chr3:135584655-135691547 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

106893 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 62.82 cM
Mapping Data

13 experiments

Human Ortholog

NFKB1, nuclear factor kappa B subunit 1

Vertebrate Orthologs

9

Human Ortholog

NFKB1, nuclear factor kappa B subunit 1
Orthology source: HomoloGene, HGNC
Synonyms

CVID12, EBP-1, KBF1, NFkappaB, NF-kappaB, NF-kappa-B, NF-kB1, NFKB-p105, NFKB-p50, p105, p50
Links

HGNC:7794

NCBI Gene ID: 4790

neXtProt AC: NX_P19838

UniProt: P19838
Chr Location

4q24; chr4:102501329-102617302 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2971
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFKB1
Protein SuperFamily

transcription factor NF-kappa-B2
Gene Tree

Nfkb1

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References

1 with disease annotations

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Phenotype Summary

93 phenotypes from 6 alleles in 13 genetic backgrounds
55 phenotypes from multigenic genotypes
220 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

83
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

74
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Nfkb1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

79 strains or lines available

Homozygous null mice have a decreased survivor rate, abnormal T cell development and decreased number of peripheral T cells, abnormal humoral responses with decreased immunoglobulin class switching, exhibit mild organ inflammation, and are susceptible toboth bacterial infections and hearing loss.

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All GO Annotations

92
GO References

42

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

234
Tissues

196
cDNA Data

116
Literature Summary

19

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Nfkb1 interacts with 139 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

66
RefSeq

6
UniProt

5
CCDS

CCDS17858.1
UniGene

256765

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016668	VEGA Gene Model \| MGI Sequence Detail	106893	C57BL/6J	± kb
transcript	OTTMUST00000040338	VEGA \| MGI Sequence Detail	4117	Not Applicable
polypeptide	OTTMUSP00000018024	VEGA \| MGI Sequence Detail	971	Not Applicable

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SNPs within 2kb

840 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000001754 nuclear factor NF-kappa-B p105 subunit

(term hierarchy)
PDB

1BFS, 1IKN, 1LE5, 1LE9, 1LEI, 1NFK, 1OOA, 1U36, 1U3J, 1U3Y, 1U3Z, 1U41, 1U42, 1VKX, 2I9T, 2V2T, 3JV4
InterPro Domains

IPR002110 Ankyrin repeat

IPR020683 Ankyrin repeat-containing domain

IPR000488 Death domain

IPR011029 Death-like domain

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR000451 NF-kappa-B/Dorsal

IPR033926 NFkappaB IPT domain

IPR030503 Nuclear factor NF-kappa-B, p105 subunit

IPR008967 p53-like transcription factor, DNA-binding

IPR032397 Rel homology dimerisation domain

IPR030492 Rel homology domain, conserved site

IPR011539 Rel homology domain (RHD), DNA-binding domain

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All nucleic 120

cDNA 117

Primer pair 3

Microarray probesets 3

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MGD-MRK-12829

Summaries

All 471

Developmental Gene Expression 19

Diseases 1

Gene Ontology 42

Phenotypes 220
Earliest

J:13626 Ferguson JM, et al., Stumpy. Mouse News Lett. 1973;49:23
Latest

J:237218 Cvijetic S, et al., Cell autonomous and noncell-autonomous role of NF-kappaB p50 in astrocyte-mediated fate specification of adult neural progenitor cells. Glia. 2017 Jan;65(1):169-181

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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