Nat1
Gene Detail

Symbol Name ID

Nat1 N-acetyl transferase 1 MGI:97279

Synonyms

Nat-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.38 cM, cytoband B3.1
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr8:67490758-67492104 bp, + strand From NCBI annotation of GRCm38   1347 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:115468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: N-hydroxyarylamine O-acetyltransferase/arylamine N-acetyltransferase/3-amino-5-hydroxybenzoic acid synthase
Gene Tree: Nat1

Human homologs

Human Homolog		NAT2, N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCBI Gene ID		10
neXtProt AC		NX_P11245
Human Synonyms		AAC2, NAT-2, PNAT
Human Chr (Location)		8p22; chr8:18248755-18258723 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NAT2

Alleles and phenotypes

All alleles(3) : Targeted(2) Chemically induced(1)
 

Mice homozygous for an ENU-induced allele exhibit reduced fertility and a significant reduction in hepatic N-acetyltransferase 1 activity.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	metabolic process
Component	cytoplasm, cytosol
Function	acetyltransferase activity, arylamine N-acetyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (100)   
Theiler Stages: 17, 22, 23, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	12

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(8) cDNA(4) Primer pair(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000025588 (Evidence)
Entrez Gene	17960 (Evidence)
UniGene	14125
DFCI	TC1594279
DoTS	DT.87039541
EC	2.3.1.5
Consensus CDS Project	CCDS22337.1
International Mouse Knockout Project Status	Nat1

Sequences

Length	Strain/Species
genomic	17960	NCBI Gene Model | MGI Sequence Detail	1347	C57BL/6J
transcript	NM_008673	RefSeq | MGI Sequence Detail	1347	C57BL/6
polypeptide	P50294	UniProt | EBI | MGI Sequence Detail	290	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001447	Arylamine N-acetyltransferase
Protein Ontology	PR:000010994	arylamine N-acetyltransferase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:13876 Glowinski I, et al., Liver N-acetyl transferase. Mouse News Lett. 1981;64:71
(Latest) J:184393 Sugamori KS, et al., Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice. Cancer Lett. 2012 May 28;318(2):206-13
All references(42)

Other accession IDs

MGD-MRK-12778, MGD-MRK-12780