About   Help   FAQ
Nat1 Gene Detail
Summary
  • Symbol
    Nat1
  • Name
    N-acetyl transferase 1
  • Synonyms
    Nat-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97279
    NCBI Gene: 17960
Location & Maps
more
  • Sequence Map
    Chr8:67490758-67492104 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1347 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.38 cM, cytoband B3.1
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    NAT1, N-acetyltransferase 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    NAT1, N-acetyltransferase 1
    Orthology source: HGNC
  • Synonyms
    AAC1, MNAT, NAT-1, NATI
  • Links
    NCBI Gene ID: 9
    neXtProt AC: NX_P18440

  • Chr Location
    8p22; chr8:18170462-18223689 (+)  GRCh38.p2

  • Human Ortholog
    NAT2, N-acetyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAC2, NAT-2, PNAT
  • Links
    NCBI Gene ID: 10
    neXtProt AC: NX_P11245

  • Chr Location
    8p22; chr8:18391245-18401219 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NAT2 associations

Human Disease Mouse Models
       Acetylation, Slow   OMIM: 243400
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Nat1
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit reduced fertility and a significant reduction in hepatic N-acetyltransferase 1 activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025588 Ensembl Gene Model | MGI Sequence Detail 1347 C57BL/6J ±  kb
transcript ENSMUST00000026677 Ensembl | MGI Sequence Detail 1347 Not Applicable  
polypeptide ENSMUSP00000026677 Ensembl | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    79 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000044706 rodent arylamine N-acetyltransferase 1
  • EC
  • InterPro Domains
    IPR001447 Arylamine N-acetyltransferase
Molecular
Reagents
less
  • All nucleic 14
    Genomic 8
    cDNA 4
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-12778, MGD-MRK-12780
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:13876 Glowinski I, et al., Liver N-acetyl transferase. Mouse News Lett. 1981;64:71
  • Latest
    J:222271 Knowles JW, et al., Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest. 2015 Apr;125(4):1739-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory