About   Help   FAQ
Nat1
Gene Detail
Symbol

Name
ID
Nat1
N-acetyl transferase 1
MGI:97279
Synonyms
Nat-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
33.38 cM, cytoband B3.1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr8:67490758-67492104 bp, + strand
From Ensembl annotation of GRCm38

  1347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: N-hydroxyarylamine O-acetyltransferase/arylamine N-acetyltransferase/3-amino-5-hydroxybenzoic acid synthase
Gene Tree: Nat1

Human
homologs
Human Homolog NAT2, N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCBI Gene ID 10
neXtProt AC  NX_P11245
Human Synonyms  AAC2, NAT-2, PNAT
Human Chr (Location)  8p22; chr8:18391245-18401213 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NAT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit reduced fertility and a significant reduction in hepatic N-acetyltransferase 1 activity.
 
Interactions
Nat1 interacts with 55 markers (Mir7-2, Mir7b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process metabolic process
Component cytoplasm, cytosol
Function acetyltransferase activity, arylamine N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (106)    Tissues (101)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(8) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025588 (Evidence)
Entrez Gene17960 (Evidence)
UniGene14125
DFCITC1594279
DoTSDT.87039541
EC2.3.1.5
Consensus CDS ProjectCCDS22337.1
International Mouse Knockout Project StatusNat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025588 Ensembl Gene Model | MGI Sequence Detail 1347 C57BL/6J ±  kb
transcript ENSMUST00000026677 Ensembl | MGI Sequence Detail 1347 Not Applicable 
polypeptide ENSMUSP00000026677 Ensembl | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001447 Arylamine N-acetyltransferase
Protein Ontology PR:000010994 arylamine N-acetyltransferase 1
References
(Earliest) J:13876 Glowinski I, et al., Liver N-acetyl transferase. Mouse News Lett. 1981;64:71
(Latest) J:202012 Pandey RR, et al., Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
All references(44)
Other
accession IDs
MGD-MRK-12778, MGD-MRK-12780

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory