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Msx1
Gene Detail
Symbol

Name
ID
Msx1
msh homeobox 1
MGI:97168
STS
Synonyms
Hox7, Hox-7, Hox7.1, msh, muscle-segment homeobox
Feature Type
protein coding gene
Genetic Map
Chromosome 5
20.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr5:37820485-37824583 bp, - strand
From VEGA annotation of GRCm38

  4099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Msx1

Human
homologs
Human Homolog MSX1, msh homeobox 1
NCBI Gene ID 4487
neXtProt AC  NX_P28360
Human Synonyms  ECTD3, HOX7, HYD1, STHAG1
Human Chr (Location)  4p16.2; chr4:4859665-4863936 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MSX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(7)
Genomic Mutations involving Msx1 (2)
 
Mutants affect craniofacial neural crest-derived mesenchyme by controlling cell cycle progression. Homozygous null mutants die at birth with multiple craniofacial defects including cleft palate, reduced mandible and maxilla, and retarded tooth development.
 
Human Diseases Modeled Using Mouse Msx1 (2)    Alleles Annotated to Human Diseases(4)   
Interactions
Msx1 interacts with 151 markers (Mir1b, Mir7-1, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (89 annotations)
Process activation of meiosis, anterior/posterior pattern specification, ...
Component cytoplasm, nucleus, ...
Function DNA binding, p53 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (439 records)
Data Summary: Results (1029)    Tissues (651)    Images (311)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 871
In situ reporter (knock in) 94
Northern blot 14
Western blot 6
RT-PCR 35
Nuclease S1 1
cDNA source data(62)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(122) Genomic(15) cDNA(71) Primer pair(8) Other(28)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021309 (Evidence)
Ensembl Gene ModelENSMUSG00000048450 (Evidence)
Entrez Gene17701 (Evidence)
UniGene256509
DFCITC1579754, TC1681949, TC1762760
DoTSDT.110690872, DT.490453
NIA Mouse Gene IndexU026132
PDB1IG7
Consensus CDS ProjectCCDS19249.1
International Mouse Knockout Project StatusMsx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021309 VEGA Gene Model | MGI Sequence Detail 4099 C57BL/6J ±  kb
transcript OTTMUST00000050525 VEGA | MGI Sequence Detail 1935 Not Applicable 
polypeptide OTTMUSP00000023597 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(7) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010686 homeobox protein MSX-1
References
(Earliest) J:14222 Davidson D, et al., Homeobox expression in the developing mouse. Mouse News Lett. 1988;82:102
(Latest) J:210983 Chang AC, et al., A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 2014 Jul;243(7):894-905
All references(546)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10867, MGD-MRK-12570, MGI:2140786, MGI:2140836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory