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Msx1
Gene Detail
Symbol

Name
ID
Msx1
msh homeobox 1
MGI:97168
STS
Synonyms
Hox7, Hox-7, Hox7.1, msh, muscle-segment homeobox
Feature Type
protein coding gene
Genetic Map
Chromosome 5
20.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr5:37820485-37824583 bp, - strand
From VEGA annotation of GRCm38

  4099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSX1
Gene Tree: Msx1

Human
homologs
MSX1, msh homeobox 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4487
neXtProt AC: NX_P28360

Human Synonyms: ECTD3, HOX7, HYD1, STHAG1

Human Chr (Location): 4p16.2; chr4:4859665-4863936 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human MSX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Radiation induced(2) Targeted(8)
Genomic Mutations involving Msx1 (3)
 
Mutants affect craniofacial neural crest-derived mesenchyme by controlling cell cycle progression. Homozygous null mutants die at birth with multiple craniofacial defects including cleft palate, reduced mandible and maxilla, and retarded tooth development.
 
Human Diseases Modeled in Mice Using Msx1 (2)    Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Msx1 interacts with 151 markers (Mir1b, Mir7-1, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process activation of meiosis, anterior/posterior pattern specification, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, p53 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (456 records)
Data Summary: Results (1033)    Tissues (652)    Images (315)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 875
In situ reporter (knock in) 94
Northern blot 14
Western blot 6
RT-PCR 35
Nuclease S1 1
cDNA source data(62)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA MSX1 ; Xenbase msx1 ; ZFIN msxe    NEW 
Molecular
reagents
All nucleic(123) Genomic(15) cDNA(71) Primer pair(8) Other(29)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021309 (Evidence)
Ensembl Gene Model ENSMUSG00000048450 (Evidence)
Entrez Gene 17701 (Evidence)
UniGene 256509
DFCI TC1579754, TC1681949, TC1762760
DoTS DT.110690872, DT.490453
NIA Mouse Gene Index U026132
PDB 1IG7
Consensus CDS Project CCDS19249.1
International Mouse Phenotyping Consortium Status Msx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021309 VEGA Gene Model | MGI Sequence Detail 4099 C57BL/6J ±  kb
transcript OTTMUST00000050525 VEGA | MGI Sequence Detail 1935 Not Applicable 
polypeptide OTTMUSP00000023597 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(7) : SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000010686 homeobox protein MSX-1
References
(Earliest) J:14222 Davidson D, et al., Homeobox expression in the developing mouse. Mouse News Lett. 1988;82:102
(Latest) J:222399 Kitazawa T, et al., Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74
All references(563)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10867, MGD-MRK-12570, MGI:2140786, MGI:2140836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory