Msx1
Gene Detail

Symbol Name ID

Msx1 homeobox, msh-like 1 MGI:97168

STS

D5Mit421

Synonyms

Hox7, Hox-7, Hox7.1, msh, muscle-segment homeobox

Feature Type

protein coding gene

Genetic Map

Chromosome 5

20.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr5:37820485-37824583 bp, - strand From VEGA annotation of GRCm38   4099 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Msx1

Human homologs

Human Homolog		MSX1, msh homeobox 1
NCBI Gene ID		4487
neXtProt AC		NX_P28360
Human Synonyms		ECTD3, HOX7, HYD1, STHAG1
Human Chr (Location)		4p16.2; chr4:4861392-4865663 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MSX1

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mutants affect craniofacial neural crest-derived mesenchyme by controlling cell cycle progression. Homozygous null mutants die at birth with multiple craniofacial defects including cleft palate, reduced mandible and maxilla, and retarded tooth development.

 
Human Diseases Modeled Using Mouse Msx1 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	anterior/posterior pattern specification, apoptotic nuclear changes, ...
Component	nucleus, transcription factor complex
Function	DNA binding, p53 binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (405 records)
Data Summary: Results (951)    Tissues (603)    Images (275)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	802
In situ reporter (knock in)	94
Northern blot	14
RT-PCR	32
Nuclease S1	1

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(87) Genomic(15) cDNA(41) Primer pair(7) Other(24)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021309 (Evidence)
Ensembl Gene Model	ENSMUSG00000048450 (Evidence)
Entrez Gene	17701 (Evidence)
DFCI	TC1579754, TC1681949, TC1762760
DoTS	DT.110690872, DT.490453
NIA Mouse Gene Index	U026132
PDB	1IG7
Consensus CDS Project	CCDS19249.1
International Mouse Knockout Project Status	Msx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021309	VEGA Gene Model | MGI Sequence Detail	4099	C57BL/6J
transcript	OTTMUST00000050525	VEGA | MGI Sequence Detail	1935	Not Applicable
polypeptide	OTTMUSP00000023597	VEGA | MGI Sequence Detail	303	Not Applicable

All sequences(29) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(7) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000010686	homeobox protein MSX-1

References

(Earliest) J:14222 Davidson D, et al., Homeobox expression in the developing mouse. Mouse News Lett. 1988;82:102
(Latest) J:194129 Lallemand Y, et al., Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele. Genesis. 2013 Feb;51(2):110-9
All references(509)

Other accession IDs

MGD-MRK-10867, MGD-MRK-12570, MGI:2140786, MGI:2140836