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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Msx1
msh homeobox 1
MGI:97168
99 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Barx1tm1Shiv/Barx1tm1Shiv
Msx1tm1Bero/Msx1+
involves: 129P2/OlaHsd * various 		arrest of tooth development J:180393
Dlx5tm1Levi/Dlx5tm1Levi
Msx1tm1Bero/Msx1tm1Bero
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal alisphenoid bone morphology J:104286
abnormal basioccipital bone morphology J:104286
abnormal basisphenoid bone morphology J:104286
abnormal fontanelle morphology J:104286
abnormal malleus morphology J:104286
abnormal nasal capsule morphology J:104286
abnormal neurocranium morphology J:104286
abnormal otic capsule morphology J:104286
abnormal pterygoid bone morphology J:104286
abnormal temporal bone squamous part morphology J:104286
absent alveolar process J:104286
absent malleus head J:104286
absent mandibular coronoid process J:104286
absent molars J:104286
cleft secondary palate J:104286
delayed bone ossification J:104286
micrognathia J:104286
neonatal lethality, complete penetrance J:104286
palatal shelves fail to meet at midline J:104286
Gsctm1Pgr/Gsctm1Pgr
Msx1tm1Rilm/Msx1tm1Rilm
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal Meckel's cartilage morphology J:59750
abnormal tympanic cavity morphology J:59750
absent external auditory canal J:59750
absent malleus processus brevis J:59750
cleft palate J:59750
decreased tympanic ring size J:59750
Isl1tm1(cre)Sev/Isl1+
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1.1Hpt
involves: 129 * CD-1 		aberrant origin of the right subclavian artery J:311535
abnormal hyoid bone greater horn morphology J:311535
abnormal hyoid bone lesser horn morphology J:311535
abnormal hyoid bone morphology J:311535
abnormal inferior horn of thyroid cartilage morphology J:311535
abnormal superior horn of thyroid cartilage morphology J:311535
craniofacial phenotype J:311535
neonatal lethality, complete penetrance J:311535
preaxial polydactyly J:311535
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J 		decreased brain size J:84975
decreased embryo size J:84975
embryonic lethality during organogenesis, incomplete penetrance J:84975
exencephaly J:84975
spina bifida J:84975
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * 129P2/OlaHsd 		abnormal neural tube morphology J:208848
decreased embryo size J:208848
decreased spinal cord size J:208848
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * C57BL/6 * NMRI 		abnormal apical ectodermal ridge morphology J:98917
abnormal carpal bone morphology J:98917
abnormal pelvic girdle bone morphology J:98917
abnormal tarsal bone morphology J:98917
absent pubis J:98917
interdigital webbing J:98917
lethality throughout fetal growth and development, complete penetrance J:98917
oligodactyly J:98917
polydactyly J:98917
short limbs J:98917
small limb buds J:98917
small scapula J:98917
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
involves: 129/Sv * BALB/c * C57BL/6 * SJL 		abnormal craniofacial development J:136241
cleft palate J:136241
perinatal lethality J:136241
short snout J:136241
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Bero/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI 		abnormal artery morphology J:173525
abnormal carotid artery morphology J:173525
abnormal vertebral artery morphology J:173525
intracranial aneurysm J:173525
intracranial hemorrhage J:173525
vascular smooth muscle hypoplasia J:173525
Msx1tm1Bero/Msx1tm1Bero
Msx2tm1Yvla/Msx2tm1Yvla
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL 		abnormal craniofacial morphology J:136241
abnormal limb development J:136241
exencephaly J:136241
lethality throughout fetal growth and development, complete penetrance J:136241
thoracoabdominoschisis J:136241
Msx1tm1Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Yvla/Msx2tm1Yvla
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI 		abnormal carotid artery morphology J:173525
vascular smooth muscle hypoplasia J:173525
Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Taglntm2(cre)Yec/Tagln+
involves: 129S2/SvPas * 129S6/SvEvTac * NMRI 		abnormal carotid artery morphology J:173525
vascular smooth muscle hypoplasia J:173525
Msx1tm1Rem/Msx1tm1Rem
Msx2tm1Yvla/Msx2tm1Yvla
Tg(Tek-cre)1Ywa/0
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL 		normal cardiovascular system phenotype J:173525
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9+
involves: 129 * CD-1 		decreased tooth number J:311535
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1Rbal
involves: 129 * CD-1 		aberrant origin of the right subclavian artery J:311535
abnormal aorta morphology J:311535
abnormal common carotid artery morphology J:311535
abnormal first pharyngeal arch artery morphology J:311535
abnormal fourth pharyngeal arch artery morphology J:311535
abnormal second pharyngeal arch artery morphology J:311535
abnormal third pharyngeal arch artery morphology J:311535
cleft secondary palate J:311535
decreased neural crest cell number J:311535
double outlet right ventricle J:311535
ectopic thymus J:311535
fourth pharyngeal arch artery hypoplasia J:311535
interrupted aortic arch J:311535
neonatal lethality J:311535
preaxial polydactyly J:311535
third pharyngeal arch artery hypoplasia J:311535
thymus hypoplasia J:311535
Msx1tm1Rilm/Msx1+
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * CD-1 		normal hearing/vestibular/ear phenotype J:83306
Msx1tm1Rilm/Msx1tm1Rilm
Msx2tm1Rilm/Msx2+
involves: 129S4/SvJae * CD-1 		normal hearing/vestibular/ear phenotype J:83306
Msx1tm1Rilm/Msx1tm1Rilm
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * BALB/c * CD-1 		abnormal atrioventricular cushion morphology J:139946
abnormal cardiac epithelial to mesenchymal transition J:139946
abnormal heart valve morphology J:139946
abnormal mammary gland development J:61509
abnormal neurocranium morphology J:61509
arrest of tooth development J:61509
atrial septal defect J:139946
atrioventricular cushion hypoplasia J:139946
decreased hair follicle number J:61509
Msx1tm1Rilm/Msx1tm1Rilm
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * CD-1 		abnormal external auditory canal morphology J:83306
abnormal malleus morphology J:83306
abnormal Meckel's cartilage morphology J:83306
abnormal middle ear ossicle morphology J:83306
absent malleus manubrium J:83306
absent malleus processus brevis J:83306
absent tympanic ring J:83306
small malleus J:83306
Msx1tm1Rilm/Msx1tm1Rilm
Pax9tm1Rbal/Pax9+
involves: 129 * CD-1 		cleft palate J:311535
Msx1tm1Rilm/Msx1tm1Rilm
Pax9tm1Rbal/Pax9tm1Rbal
involves: 129 * CD-1 		aberrant origin of the right subclavian artery J:311535
abnormal pharyngeal arch artery morphology J:311535
double outlet right ventricle J:311535
interrupted aortic arch, type b J:311535
normal limbs/digits/tail phenotype J:311535
Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero
Msx2tm1Bero/Msx2tm1Bero
involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		absent gastric milk in neonates J:194129
absent malleus processus brevis J:194129
absent teeth J:194129
cleft secondary palate J:194129
neonatal lethality J:194129
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory