Msx1tm2.1(cre/ERT2)Bero
Targeted Allele Detail
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Symbol: |
Msx1tm2.1(cre/ERT2)Bero |
Name: |
msh homeobox 1; targeted mutation 2.1, Benoit Robert |
MGI ID: |
MGI:5049923 |
Synonyms: |
Msx1CreERT2, Msx1-CreERT2, Msx1tm2(cre/ERT2)Bero |
Gene: |
Msx1 Location: Chr5:37977835-37981929 bp, - strand Genetic Position: Chr5, 20.21 cM
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Alliance: |
Msx1tm2.1(cre/ERT2)Bero page
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Germline Transmission: |
Earliest citation of germline transmission:
J:173525
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Parent Cell Line: |
CK35 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Msx1tm2.1(cre/ERT2)Bero expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Msx1 (MGI:97168) |
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Mutation details: A targeting vector with the cre/ERT2 sequence, polyadenylation site, and an Frt-flanked neomycin cassette inserted into the ATG site of Msx1 in a plasmid was generated by homologous recombination in bacteria. The linearized targeting vector was electroporated into ES cells and targeted clones were used to generated chimeras. F1 offspring were crossed to Flp deleter mice to delete the neo marker.
(J:173525, J:194129)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Msx1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:173525 Lopes M, et al., Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development. 2011 Jul;138(14):3055-66 |
All: |
14 reference(s) |
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