Mpl
Gene Detail

Symbol Name ID

Mpl myeloproliferative leukemia virus oncogene MGI:97076

Synonyms

CD110, c-mpl, c-mpl-I, c-mpl-II, hlb219, thrombopoietin receptor, TPO-R

Feature Type

protein coding gene

Genetic Map

Chromosome 4

54.61 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr4:118442415-118457513 bp, - strand From VEGA annotation of GRCm38   15099 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7845  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: thrombopoietin receptor
Gene Tree: Mpl

Human homologs

Human Homolog		MPL, myeloproliferative leukemia virus oncogene
NCBI Gene ID		4352
neXtProt AC		NX_P40238
Human Synonyms		CD110, C-MPL, MPLV, THCYT2, TPOR
Human Chr (Location)		1p34; chr1:43803475-43820135 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human MPL

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.

 
Human Diseases Modeled Using Mouse Mpl (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	homeostasis of number of cells, regulation of chemokine production
Component	integral to membrane, membrane, ...
Function	cytokine receptor activity

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (52)    Tissues (38)    Images (1)
Theiler Stages: 9, 10, 12, 14, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	20
RT-PCR	27
Nuclease S1	4

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(17) Primer pair(7) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008795 (Evidence)
Ensembl Gene Model	ENSMUSG00000006389 (Evidence)
Entrez Gene	17480 (Evidence)
UniGene	4864
DFCI	TC1586267, TC1596239, TC1698970
DoTS	DT.101352829, DT.110797680, DT.55282840, DT.97332952, DT.97385658
NIA Mouse Gene Index	U025448
Consensus CDS Project	CCDS18552.1, CCDS51284.1
International Mouse Knockout Project Status	Mpl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008795	VEGA Gene Model | MGI Sequence Detail	15099	C57BL/6J
transcript	OTTMUST00000019997	VEGA | MGI Sequence Detail	2045	Not Applicable
polypeptide	OTTMUSP00000009174	VEGA | MGI Sequence Detail	626	Not Applicable

All sequences(50) RefSeq(4) UniProt(7)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(79 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003528	Long hematopoietin receptor, single chain, conserved site
Protein Ontology	PR:000001939	thrombopoietin receptor

References

(Earliest) J:9693 Wendling F, et al., Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus. Blood. 1989 Apr;73(5):1161-7
(Latest) J:194947 de Laval B, et al., Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell. 2013 Jan 3;12(1):37-48
All references(110)

Other accession IDs

MGD-MRK-12409, MGI:2678710