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Mpl
Gene Detail
 Symbol
Name
ID
Mpl
myeloproliferative leukemia virus oncogene
MGI:97076
Synonyms CD110, c-mpl, c-mpl-I, c-mpl-II, hlb219, thrombopoietin receptor, TPO-R
Feature Type protein coding gene
Genetic Map
Chromosome 4
54.61 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr4:118442415-118457513 bp, - strand
From VEGA annotation of GRCm38

  15099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7845  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: thrombopoietin receptor
Gene Tree: Mpl

Human
homologs
Human Homolog MPL, MPL proto-oncogene, thrombopoietin receptor
NCBI Gene ID 4352
neXtProt AC  NX_P40238
Human Synonyms  CD110, C-MPL, MPLV, THCYT2, TPOR
Human Chr (Location)  1p34; chr1:43337804-43354464 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human MPL
Alleles
and
phenotypes
All alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
 
Human Diseases Modeled Using Mouse Mpl (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process homeostasis of number of cells, regulation of chemokine production
Component integral component of membrane, membrane, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (52)    Tissues (38)    Images (1)
Theiler Stages: 9, 10, 12, 14, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 1
Northern blot 20
RT-PCR 27
Nuclease S1 4
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(17) Primer pair(7) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008795 (Evidence)
Ensembl Gene ModelENSMUSG00000006389 (Evidence)
Entrez Gene17480 (Evidence)
UniGene4864
DFCITC1586267, TC1596239, TC1698970
DoTSDT.101352829, DT.110797680, DT.55282840, DT.97332952, DT.97385658
NIA Mouse Gene IndexU025448
Consensus CDS ProjectCCDS18552.1, CCDS51284.1
International Mouse Knockout Project StatusMpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008795 VEGA Gene Model | MGI Sequence Detail 15099 C57BL/6J ±  kb
transcript OTTMUST00000019997 VEGA | MGI Sequence Detail 2045 Not Applicable 
polypeptide OTTMUSP00000009174 VEGA | MGI Sequence Detail 626 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(7)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(110 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003528 Long hematopoietin receptor, single chain, conserved site
Protein Ontology PR:000001939 thrombopoietin receptor
References (Earliest) J:9693 Wendling F, et al., Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus. Blood. 1989 Apr;73(5):1161-7
(Latest) J:207699 de Laval B, et al., Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-kappaB pathways and their target, IEX-1. Blood. 2014 Jan 23;123(4):509-19
All references(114)
Other
accession IDs
MGD-MRK-12409, MGI:2678710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory