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Mpl Gene Detail
Summary
  • Symbol
    Mpl
  • Name
    myeloproliferative leukemia virus oncogene
  • Synonyms
    CD110, c-mpl, c-mpl-I, c-mpl-II, hlb219, thrombopoietin receptor, TPO-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:97076
    NCBI Gene: 17480
  • Gene Overview
    MyGene.info: MPL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:118442415-118457513 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15099 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.61 cM, cytoband D
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD110, C-MPL, MPLV, THCYT2, TPOR
  • Links
    NCBI Gene ID: 4352
    neXtProt AC: NX_P40238
    UniProt: P40238

  • Chr Location
    1p34.2; chr1:43336875-43354464 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Mpl mouse models; 3 with human MPL associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 6 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008795 VEGA Gene Model | MGI Sequence Detail 15099 C57BL/6J ±  kb
    transcript OTTMUST00000019997 VEGA | MGI Sequence Detail 2045 Not Applicable  
    polypeptide OTTMUSP00000009174 VEGA | MGI Sequence Detail 626 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      110 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR015152 Growth hormone/erythropoietin receptor, ligand binding
      IPR013783 Immunoglobulin-like fold
      IPR003528 Long hematopoietin receptor, single chain, conserved site
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 19
      Primer pair 10
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12409, MGI:2678710
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 8
      Phenotypes 67
    • Earliest
      J:9693 Wendling F, et al., Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus. Blood. 1989 Apr;73(5):1161-7
    • Latest
      J:241035 Du C, et al., Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1. Leukemia. 2017 Apr;31(4):945-956

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory