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Mpl Gene Detail
Summary
  • Symbol
    Mpl
  • Name
    myeloproliferative leukemia virus oncogene
  • Synonyms
    CD110, c-mpl, c-mpl-I, c-mpl-II, hlb219, thrombopoietin receptor, TPO-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:97076
    NCBI Gene: 17480
Location & Maps
more
  • Sequence Map
    Chr4:118442415-118457513 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15099 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MPL, MPL proto-oncogene, thrombopoietin receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD110, C-MPL, MPLV, THCYT2, TPOR
  • Links
    NCBI Gene ID: 4352
    neXtProt AC: NX_P40238

  • Chr Location
    1p34; chr1:43337418-43354464 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mpl mouse models; 3 with human MPL associations

Human Disease Mouse Models
       Amegakaryocytic Thrombocytopenia, Congenital; CAMT   OMIM: 604498 View 1 model
       Myelofibrosis   OMIM: 254450
Thrombocythemia 2; THCYT2   OMIM: 601977
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 6 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Mpl
  • Incidental Mutations
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008795 VEGA Gene Model | MGI Sequence Detail 15099 C57BL/6J ±  kb
transcript OTTMUST00000019997 VEGA | MGI Sequence Detail 2045 Not Applicable  
polypeptide OTTMUSP00000009174 VEGA | MGI Sequence Detail 626 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    110 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000001939 thrombopoietin receptor
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR015152 Growth hormone/erythropoietin receptor, ligand binding
    IPR013783 Immunoglobulin-like fold
    IPR003528 Long hematopoietin receptor, single chain, conserved site
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 17
    Primer pair 7
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12409, MGI:2678710
References
more
  • Summaries
    All 114
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 7
    Phenotypes 61
  • Earliest
    J:9693 Wendling F, et al., Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus. Blood. 1989 Apr;73(5):1161-7
  • Latest
    J:225923 Potts KS, et al., Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015 Aug 6;126(6):807-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory