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Mmp9 Gene Detail
Summary
  • Symbol
    Mmp9
  • Name
    matrix metallopeptidase 9
  • Synonyms
    B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:97011
    NCBI Gene: 17395
  • Gene Overview
    MyGene.info: MMP9
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164940780-164955850 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.27 cM, cytoband H1-H2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97011
protein coding gene Chr2:164940744-164955850 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026883
protein coding gene Chr2:170459606-170477486 (+)
A/J MGP_AJ_G0026850
protein coding gene Chr2:163480219-163496348 (+)
AKR/J MGP_AKRJ_G0026821
protein coding gene Chr2:168362180-168377272 (+)
BALB/cJ MGP_BALBcJ_G0026859
protein coding gene Chr2:163846832-163861927 (+)
C3H/HeJ MGP_C3HHeJ_G0026601
protein coding gene Chr2:168707803-168723495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027306
protein coding gene Chr2:175394242-175411062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024677
protein coding gene Chr2:156889473-156904927 (+)
CAST/EiJ MGP_CASTEiJ_G0026059
protein coding gene Chr2:169124522-169139621 (+)
CBA/J MGP_CBAJ_G0026578
protein coding gene Chr2:181758074-181776385 (+)
DBA/2J MGP_DBA2J_G0026716
protein coding gene Chr2:162646631-162662267 (+)
FVB/NJ MGP_FVBNJ_G0026682
protein coding gene Chr2:161071839-161086907 (+)
LP/J MGP_LPJ_G0026818
protein coding gene Chr2:170513968-170529015 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026701
protein coding gene Chr2:185302214-185318058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027363
protein coding gene Chr2:168247973-168263028 (+)
PWK/PhJ MGP_PWKPhJ_G0025796
protein coding gene Chr2:162250546-162265661 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025597
protein coding gene Chr2:167151579-167169440 (+)
WSB/EiJ MGP_WSBEiJ_G0026132
protein coding gene Chr2:169129635-169148710 (+)



Homology
more
  • Human Ortholog
    MMP9, matrix metallopeptidase 9
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MMP9, matrix metallopeptidase 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLG4B, GELB, MANDP2, MMP-9
  • Links
    NCBI Gene ID: 4318
    neXtProt AC: NX_P14780
    UniProt: P14780

  • Chr Location
    20q13.12; chr20:46008908-46016561 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    98 phenotypes from 5 alleles in 20 genetic backgrounds
    47 phenotypes from multigenic genotypes
    260 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mutants have short long bones with compensatory growth via delayed ossification and apoptosis of hypertrophic chondroctyes. Mutants are protected against ischemic brain injury, damage caused by myocardial infarction, and allergic airway inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017737 Ensembl Gene Model | MGI Sequence Detail 15071 C57BL/6J ±  kb
    transcript ENSMUST00000017881 Ensembl | MGI Sequence Detail 3175 Not Applicable  
    polypeptide ENSMUSP00000017881 Ensembl | MGI Sequence Detail 730 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 2
      cDNA 30
      Primer pair 15
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12281, MGD-MRK-2014, MGI:2139414
    References
    more
    • Summaries
      All 602
      Developmental Gene Expression 162
      Diseases 2
      Gene Ontology 14
      Phenotypes 260
    • Earliest
      J:3961 Tanaka H, et al., Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun. 1993 Feb 15;190(3):732-40
    • Latest
      J:266452 Albrengues J, et al., Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018 Sep 28;361(6409)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory