Mmp9
Gene Detail

Symbol Name ID

Mmp9 matrix metallopeptidase 9 MGI:97011

Synonyms

B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9

Feature Type

protein coding gene

Genetic Map

Chromosome 2

85.27 cM, cytoband H1-H2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr2:164940780-164955850 bp, + strand From VEGA annotation of GRCm38   15071 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: gelatinase A
Gene Tree: Mmp9

Human homologs

Human Homolog		MMP9, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
NCBI Gene ID		4318
neXtProt AC		NX_P14780
Human Synonyms		CLG4B, GELB, MANDP2, MMP-9
Human Chr (Location)		20q11.2-q13.1; chr20:44637547-44645200 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MMP9

Alleles and phenotypes

All alleles(10) : Targeted(8) Gene trapped(2)
 

Null mutants have short long bones with compensatory growth via delayed ossification and apoptosis of hypertrophic chondroctyes. Mutants are protected against ischemic brain injury, damage caused by myocardial infarction, and allergic airway inflammation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cellular response to cell-matrix adhesion, collagen catabolic process, ...
Component	extracellular matrix, extracellular region, ...
Function	fibronectin binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (122 records)
Data Summary: Results (265)    Tissues (82)    Images (60)
Theiler Stages: 1, 2, 3, 4, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	198
Northern blot	4
Western blot	3
RT-PCR	48

cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(2) cDNA(23) Primer pair(13) Other(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000001184 (Evidence)
Ensembl Gene Model	ENSMUSG00000017737 (Evidence)
Entrez Gene	17395 (Evidence)
DFCI	TC1576282
DoTS	DT.491016
NIA Mouse Gene Index	U002824
EC	3.4.24.35
Consensus CDS Project	CCDS17066.1
International Mouse Knockout Project Status	Mmp9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001184	VEGA Gene Model | MGI Sequence Detail	15071	C57BL/6J
transcript	OTTMUST00000002322	VEGA | MGI Sequence Detail	3175	Not Applicable
polypeptide	OTTMUSP00000001145	VEGA | MGI Sequence Detail	730	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR013806	Kringle-like fold
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
InterPro	IPR006970	PT repeat
Protein Ontology	PR:000010491	matrix metalloproteinase-9

References

(Earliest) J:3961 Tanaka H, et al., Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun. 1993 Feb 15;190(3):732-40
(Latest) J:195511 van Deventer HW, et al., Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2. J Immunol. 2013 May 1;190(9):4861-7
All references(409)

Other accession IDs

MGD-MRK-12281, MGD-MRK-2014, MGI:2139414