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Mmp9
Gene Detail
Symbol

Name
ID
Mmp9
matrix metallopeptidase 9
MGI:97011
Synonyms
B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9
Feature Type
protein coding gene
Genetic Map
Chromosome 2
85.27 cM, cytoband H1-H2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:164940780-164955850 bp, + strand
From VEGA annotation of GRCm38

  15071 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP9
Protein SuperFamily: gelatinase A
Gene Tree: Mmp9

Human
homologs
MMP9, matrix metallopeptidase 9
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4318
neXtProt AC: NX_P14780

Human Synonyms: CLG4B, GELB, MANDP2, MMP-9

Human Chr (Location): 20q13.12; chr20:46008908-46016561 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MMP9

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(9) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants have short long bones with compensatory growth via delayed ossification and apoptosis of hypertrophic chondroctyes. Mutants are protected against ischemic brain injury, damage caused by myocardial infarction, and allergic airway inflammation.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Mmp9 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process cellular response to cell-matrix adhesion, collagen catabolic process, ...
Component extracellular exosome, extracellular matrix, ...
Function endopeptidase activity, fibronectin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (138 records)
Data Summary: Results (279)    Tissues (84)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 209
Northern blot 4
Western blot 5
RT-PCR 49
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA MMP9 ; Xenbase mmp9 ; ZFIN mmp9    NEW 
Molecular
reagents
All nucleic(48) Genomic(2) cDNA(26) Primer pair(15) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000001184 (Evidence)
Ensembl Gene Model ENSMUSG00000017737 (Evidence)
Entrez Gene 17395 (Evidence)
DFCI TC1576282
DoTS DT.491016
NIA Mouse Gene Index U002824
EC 3.4.24.35
Consensus CDS Project CCDS17066.1
International Mouse Phenotyping Consortium Status Mmp9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001184 VEGA Gene Model | MGI Sequence Detail 15071 C57BL/6J ±  kb
transcript OTTMUST00000002322 VEGA | MGI Sequence Detail 3175 Not Applicable 
polypeptide OTTMUSP00000001145 VEGA | MGI Sequence Detail 730 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR013806 Kringle-like fold
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
InterPro IPR006970 PT repeat
Protein Ontology PR:000010491 matrix metalloproteinase-9
References
(Earliest) J:3961 Tanaka H, et al., Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun. 1993 Feb 15;190(3):732-40
(Latest) J:217601 Delgado-Olguin P, et al., Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec;141(23):4610-7
All references(456)
Other
accession IDs
MGD-MRK-12281, MGD-MRK-2014, MGI:2139414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory