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Mmp9 Gene Detail
Summary
  • Symbol
    Mmp9
  • Name
    matrix metallopeptidase 9
  • Synonyms
    B/MMP9, Clg4b, gelatinase B, Gelatinase B, Gel B, MMP-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:97011
    NCBI Gene: 17395
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164782700-164797770 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM, cytoband H1-H2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97011
 protein coding gene Chr2:164782246-164797770 (+)
129S1/SvImJ ENSMUSG00200016715
 protein coding gene Chr2:161671742-161686806 (+)
A/J ENSMUSG00195024697
 protein coding gene Chr2:162011292-162018936 (+)
AKR/J ENSMUSG00220012988
 protein coding gene Chr2:161333267-161348340 (+)
BALB/cJ ENSMUSG00180048218
 protein coding gene Chr2:161465009-161472653 (+)
C3H/HeJ ENSMUSG00175050992
 protein coding gene Chr2:162215627-162223271 (+)
C57BL/6NJ ENSMUSG00215029444
 protein coding gene Chr2:161655614-161670689 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024677
 protein coding gene Chr2:156889473-156904927 (+)
CAST/EiJ ENSTCUG00005042772
 protein coding gene Chr2:160574897-160589980 (+)
CBA/J ENSMUSG00210016395
 protein coding gene Chr2:162145626-162153270 (+)
DBA/2J ENSMUSG00185042546
 protein coding gene Chr2:161882759-161890403 (+)
FVB/NJ ENSMUSG00205029468
 protein coding gene Chr2:160903668-160911312 (+)
JF1/MsJ ENSUMUG00000021766
 protein coding gene Chr2:161520654-161535654 (+)
LP/J ENSMUSG00230039466
 protein coding gene Chr2:163432829-163447890 (+)
NOD/ShiLtJ ENSMUSG00190032164
 protein coding gene Chr2:161550508-161558152 (+)
NZO/HlLtJ ENSMUSG00225052237
 protein coding gene Chr2:171437663-171452734 (+)
PWK/PhJ ENSLUMG00010042442
 protein coding gene Chr2:161417689-161432673 (+)
SPRET/EiJ ENSMSPG00010027885
 protein coding gene Chr2:164177333-164192624 (+)
WSB/EiJ ENSIUOG00005043664
 protein coding gene Chr2:161264012-161278406 (+)



Homology
more
  • Human Ortholog
    MMP9, matrix metallopeptidase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP9, matrix metallopeptidase 9
  • Synonyms
    CLG4B, GELB, MANDP2, MMP-9
  • Links
    NCBI Gene ID: 4318
    UniProt: P14780

  • Chr Location
    20q13.12; chr20:46008908-46016561 (+)  GRCh38
Human Diseases
more
  • Diseases
    31 with human MMP9 associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    104 phenotypes from 6 alleles in 21 genetic backgrounds
    42 phenotypes from multigenic genotypes
    352 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants have short long bones with compensatory growth via delayed ossification and apoptosis of hypertrophic chondroctyes. Mutants are protected against ischemic brain injury, damage caused by myocardial infarction, and allergic airway inflammation. Abolishing a miR132 binding site in the 3'' UTR leads to changes in hippocampal neuron spine morphology and enhanced long-term conditioned fear memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1151
  • Tissues
    257
  • cDNA Data
    31
  • Literature Summary
    218
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017737 Ensembl Gene Model | MGI Sequence Detail 15071 C57BL/6J ±  kb
    transcript ENSMUST00000017881 Ensembl | MGI Sequence Detail 3175 Not Applicable  
    polypeptide ENSMUSP00000017881 Ensembl | MGI Sequence Detail 730 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 2
      cDNA 33
      Primer pair 30
      Other 10
      Antibodies 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12281, MGD-MRK-2014, MGI:2139414
    References
    more
    • Summaries
      All 995
      Developmental Gene Expression 218
      Diseases 1
      Gene Ontology 18
      Phenotypes 352
    • Earliest
      J:3961 Tanaka H, et al., Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA. Biochem Biophys Res Commun. 1993 Feb 15;190(3):732-40
    • Latest
      J:388038 Yaman E, et al., Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding. Front Cell Neurosci. 2026;20:1767673
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory