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Mdk Gene Detail
Summary
  • Symbol
    Mdk
  • Name
    midkine
  • Synonyms
    Mek, MK
  • Feature Type
    protein coding gene
  • IDs
    MGI:96949
    NCBI Gene: 17242
  • Gene Overview
    MyGene.info: MDK
Location & Maps
more
  • Sequence Map
    Chr2:91929805-91932297 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2493 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MDK, midkine (neurite growth-promoting factor 2)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MDK, midkine (neurite growth-promoting factor 2)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARAP, MK, NEGF2
  • Links
    NCBI Gene ID: 4192
    neXtProt AC: NX_P21741

  • Chr Location
    11p11.2; chr11:46380784-46383837 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mdk mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    69
  • Chemically induced (other)
    1
  • Gene trapped
    60
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Mdk
Mice homozygous for disruptions in this gene are essentially normal except for some delayed development of the hippocampus and behavioral abnormalities when young.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014364 VEGA Gene Model | MGI Sequence Detail 2493 C57BL/6J ±  kb
transcript OTTMUST00000033983 VEGA | MGI Sequence Detail 1054 Not Applicable  
polypeptide OTTMUSP00000015220 VEGA | MGI Sequence Detail 140 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    15 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010265 midkine
  • InterPro Domains
    IPR000762 Midkine heparin-binding growth factor
    IPR020090 Pleiotrophin/Midkine, C-terminal domain
    IPR020091 Pleiotrophin/Midkine disulphide-rich domain
    IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved site
    IPR020089 Pleiotrophin/Midkine, N-terminal domain
Molecular
Reagents
less
  • All nucleic 200
    Genomic 4
    cDNA 185
    Primer pair 8
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12166, MGD-MRK-12189
References
more
  • Summaries
    All 121
    Developmental Gene Expression 38
    Diseases 1
    Gene Ontology 7
    Phenotypes 40
  • Earliest
    J:9111 Kadomatsu K, et al., cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun. 1988 Mar 30;151(3):1312-8
  • Latest
    J:225370 Haffner-Luntzer M, et al., Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. PLoS One. 2014;9(12):e116282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory