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Mdk
Gene Detail
 Symbol
Name
ID
Mdk
midkine
MGI:96949
Synonyms Mek, MK
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr2:91929805-91932297 bp, - strand
From VEGA annotation of GRCm38

  2493 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1792  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: pleiotrophin
Gene Tree: Mdk

Human
homologs
Human Homolog MDK, midkine (neurite growth-promoting factor 2)
NCBI Gene ID 4192
neXtProt AC  NX_P21741
Human Synonyms  ARAP, MK, NEGF2
Human Chr (Location)  11p11.2; chr11:46380784-46383837 (+)  GRCh38
Alleles
and
phenotypes
All alleles(65) : Gene trapped(60) Targeted(5)
 
Mice homozygous for disruptions in this gene are essentially normal except for some delayed development of the hippocampus and behavioral abnormalities when young.
 
Human Diseases Modeled Using Mouse Mdk (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process adrenal gland development, behavioral fear response, ...
Component cell projection, cytoplasm, ...
Function growth factor activity, heparin binding
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (372)    Tissues (239)    Images (77)
Theiler Stages: 8, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 344
Northern blot 12
RT-PCR 11
cDNA source data(185)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(200) Genomic(4) cDNA(185) Primer pair(8) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014364 (Evidence)
Ensembl Gene ModelENSMUSG00000027239 (Evidence)
Entrez Gene17242 (Evidence)
UniGene906
DFCITC1573032, TC1593978, TC1595201, TC1656013, TC1662771, TC1751248, TC1774525
NIA Mouse Gene IndexU023028
Consensus CDS ProjectCCDS16440.1
International Mouse Knockout Project StatusMdk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014364 VEGA Gene Model | MGI Sequence Detail 2493 C57BL/6J ±  kb
transcript OTTMUST00000033983 VEGA | MGI Sequence Detail 1054 Not Applicable 
polypeptide OTTMUSP00000015220 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(4)
Polymorphisms All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000762 Midkine heparin-binding growth factor
InterPro IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved site
InterPro IPR020090 Pleiotrophin/Midkine heparin-binding growth factor, C-terminal domain
InterPro IPR020091 Pleiotrophin/Midkine heparin-binding growth factor, disulphide-rich domain
InterPro IPR020089 Pleiotrophin/Midkine heparin-binding growth factor, N-terminal domain
Protein Ontology PR:000010265 midkine
References (Earliest) J:9111 Kadomatsu K, et al., cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun. 1988 Mar 30;151(3):1312-8
(Latest) J:209651 Weckbach LT, et al., The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18). Blood. 2014 Mar 20;123(12):1887-96
All references(121)
Other
accession IDs
MGD-MRK-12166, MGD-MRK-12189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory