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Mbl2
Gene Detail
 Symbol
Name
ID
Mbl2
mannose-binding lectin (protein C) 2
MGI:96924
Synonyms MBL, MBL-C, MBP-C
Feature Type protein coding gene
Genetic Map
Chromosome 19
25.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:30232957-30239682 bp, + strand
From NCBI annotation of GRCm38

  6726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110436  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 4 zebrafish

Gene Tree: Mbl2

Human
homologs
Human Homolog MBL2, mannose-binding lectin (protein C) 2, soluble
NCBI Gene ID 4153
neXtProt AC  NX_P11226
Human Synonyms  COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP1, MBP-C, MBPD
Human Chr (Location)  10q11.2; chr10:52760860-52772818 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MBL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
Interactions
Mbl2 interacts with 22 markers (Mir27a, Mir27b, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process complement activation, classical pathway, complement activation, lectin pathway, ...
Component collagen trimer, extracellular region, ...
Function calcium-dependent protein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 12
Assay TypeResults
RT-PCR 2
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(3) cDNA(42) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024863 (Evidence)
Entrez Gene17195 (Evidence)
UniGene30045
DFCITC1582711
DoTSDT.492491
NIA Mouse Gene IndexU019365
Consensus CDS ProjectCCDS29742.1
International Mouse Knockout Project StatusMbl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17195 NCBI Gene Model | MGI Sequence Detail 6726 C57BL/6J ±  kb
transcript NM_010776 RefSeq | MGI Sequence Detail 1069 BALB/c 
polypeptide P41317 UniProt | EBI | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000010220 mannose-binding protein C
Graphical View of Protein Domain Structure
References (Earliest) J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
(Latest) J:204937 Takahashi K, et al., Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status. PLoS One. 2013;8(8):e69739
All references(80)
Other
accession IDs
MGD-MRK-12125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory