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Mbl2
Gene Detail
Symbol

Name
ID
Mbl2
mannose-binding lectin (protein C) 2
MGI:96924
Synonyms
MBL, MBL-C, MBP-C
Feature Type
protein coding gene
Genetic Map
Chromosome 19
25.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:30232928-30239685 bp, + strand
From Ensembl annotation of GRCm38

  6758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110436  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 4 zebrafish

HCOP human homology predictions: MBL2
Gene Tree: Mbl2

Human
homologs
MBL2, mannose-binding lectin (protein C) 2, soluble
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4153
neXtProt AC: NX_P11226

Human Synonyms: COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP1, MBP-C, MBPD

Human Chr (Location): 10q11.2; chr10:52765380-52772841 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MBL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
Interactions
Mbl2 interacts with 22 markers (Mir27a, Mir27b, Mir33, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(3) cDNA(42) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024863 (Evidence)
Entrez Gene 17195 (Evidence)
UniGene 30045
DFCI TC1582711
DoTS DT.492491
NIA Mouse Gene Index U019365
Consensus CDS Project CCDS29742.1
International Mouse Phenotyping Consortium Status Mbl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024863 Ensembl Gene Model | MGI Sequence Detail 6758 C57BL/6J ±  kb
transcript ENSMUST00000025797 Ensembl | MGI Sequence Detail 1101 Not Applicable 
polypeptide ENSMUSP00000025797 Ensembl | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000010220 mannose-binding protein C
References
(Earliest) J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
(Latest) J:217801 Pavlov VI, et al., Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Am J Pathol. 2015 Feb;185(2):347-55
All references(80)
Other
accession IDs
MGD-MRK-12125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory