Mbl2
Gene Detail

Symbol Name ID

Mbl2 mannose-binding lectin (protein C) 2 MGI:96924

Synonyms

MBL, MBL-C, MBP-C

Feature Type

protein coding gene

Genetic Map

Chromosome 19

25.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:30232957-30239682 bp, + strand From NCBI annotation of GRCm38   6726 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 4 zebrafish

Gene Tree: Mbl2

Human homologs

Human Homolog		MBL2, mannose-binding lectin (protein C) 2, soluble
NCBI Gene ID		4153
neXtProt AC		NX_P11226
Human Synonyms		COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP1, MBP-C, MBPD
Human Chr (Location)		10q11.2; chr10:54525140-54531460 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MBL2

Alleles and phenotypes

All alleles(4) : Targeted(4)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	complement activation, classical pathway, complement activation, lectin pathway, ...
Component	collagen, extracellular region, ...
Function	calcium-dependent protein binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 12

Assay Type	Results
RT-PCR	2

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(3) cDNA(41) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024863 (Evidence)
Entrez Gene	17195 (Evidence)
UniGene	30045
DFCI	TC1582711
DoTS	DT.492491
NIA Mouse Gene Index	U019365
Consensus CDS Project	CCDS29742.1
International Mouse Knockout Project Status	Mbl2

Sequences

Length	Strain/Species
genomic	17195	NCBI Gene Model | MGI Sequence Detail	6726	C57BL/6J
transcript	NM_010776	RefSeq | MGI Sequence Detail	1069	BALB/c
polypeptide	P41317	UniProt | EBI | MGI Sequence Detail	244	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
Protein Ontology	PR:000010220	mannose-binding protein C

Graphical View of Protein Domain Structure

References

(Earliest) J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
(Latest) J:194520 Miwa T, et al., Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol. 2013 Apr 1;190(7):3552-9
All references(74)

Other accession IDs

MGD-MRK-12125