About   Help   FAQ
Mbl2 Gene Detail
Summary
  • Symbol
    Mbl2
  • Name
    mannose-binding lectin (protein C) 2
  • Synonyms
    MBL, MBL-C, MBP-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:96924
    NCBI Gene: 17195
  • Gene Overview
    MyGene.info: MBL2
Location & Maps
more
  • Sequence Map
    Chr19:30232928-30239685 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6758 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 25.14 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    MBL2, mannose binding lectin 2
  • Vertebrate Orthologs
    13
  • Human Ortholog
    MBL2, mannose binding lectin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP1, MBP-C, MBPD
  • Links
    NCBI Gene ID: 4153
    neXtProt AC: NX_P11226

  • Chr Location
    10q21.1; chr10:52765380-52772841 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 110436
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 chicken;4 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MBL2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MBL2 associations

Human Disease Mouse Models
       Mannose-Binding Lectin Deficiency   OMIM: 614372
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    44 phenotype references
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024863 Ensembl Gene Model | MGI Sequence Detail 6758 C57BL/6J ±  kb
transcript ENSMUST00000025797 Ensembl | MGI Sequence Detail 1101 Not Applicable  
polypeptide ENSMUSP00000025797 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    101 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 3
    cDNA 42
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12125
References
more
  • Summaries
    All 80
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 44
  • Earliest
    J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
  • Latest
    J:235978 Ciencewicki JM, et al., Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L280-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory