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Krt14
Gene Detail
 Symbol
Name
ID
Krt14
keratin 14
MGI:96688
Synonyms Cytokeratin 14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, K14, Krt-1.14, Krt1-14
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:100203162-100207548 bp, - strand
From VEGA annotation of GRCm38

  4387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Krt14

Human
homologs
Human Homolog KRT14, keratin 14
NCBI Gene ID 3861
neXtProt AC  NX_P02533
Human Synonyms  CK14, EBS3, EBS4, K14, NFJ
Human Chr (Location)  17q21.2; chr17:41582279-41586895 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human KRT14
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations develop extensive skin blistering after birth and die by 2 days of age. If keratin 16 is also expressed in skin, development is normal but later alopecia, chronic skin ulcers and stratified epithelial defects occur.
 
Human Diseases Modeled Using Mouse Krt14 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(7)
Interactions
Krt14 interacts with 38 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process aging, epithelial cell differentiation, ...
Component cell periphery, cytoplasm, ...
Function keratin filament binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (227 records)
Data Summary: Results (387)    Tissues (142)    Images (108)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 120
RNA in situ 252
Western blot 6
RT-PCR 9
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) Genomic(3) cDNA(117) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000002538 (Evidence)
Ensembl Gene ModelENSMUSG00000045545 (Evidence)
Entrez Gene16664 (Evidence)
UniGene439898
DFCITC1575861
DoTSDT.101394427, DT.60141873
NIA Mouse Gene IndexU051737
Consensus CDS ProjectCCDS25413.1
International Mouse Knockout Project StatusKrt14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002538 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
transcript OTTMUST00000004962 VEGA | MGI Sequence Detail 1698 Not Applicable 
polypeptide OTTMUSP00000002389 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009454 keratin, type I cytoskeletal 14
References (Earliest) J:30054 Knapp B, et al., Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. J Biol Chem. 1987 Jan 15;262(2):938-45
(Latest) J:208404 Cowley M, et al., Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biol. 2014 Feb;12(2):e1001799
All references(304)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11632, MGD-MRK-11643, MGI:2144242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory