About   Help   FAQ
Krt14
Gene Detail
Symbol

Name
ID
Krt14
keratin 14
MGI:96688
Synonyms
Cytokeratin 14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, K14, Krt-1.14, Krt1-14
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:100203162-100207548 bp, - strand
From VEGA annotation of GRCm38

  4387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KRT14
Gene Tree: Krt14

Human
homologs
KRT14, keratin 14, type I
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3861
neXtProt AC: NX_P02533

Human Synonyms: CK14, EBS3, EBS4, K14, NFJ

Human Chr (Location): 17q21.2; chr17:41582279-41586895 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human KRT14

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Genomic Mutations involving Krt14 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations develop extensive skin blistering after birth and die by 2 days of age. If keratin 16 is also expressed in skin, development is normal but later alopecia, chronic skin ulcers and stratified epithelial defects occur.
 
Human Diseases Modeled in Mice Using Krt14 (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(7)
Interactions
Krt14 interacts with 38 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process aging, epithelial cell differentiation, ...
Component cell periphery, cytoplasm, ...
Function keratin filament binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (253 records)
Data Summary: Results (393)    Tissues (148)    Images (111)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 125
RNA in situ 252
Western blot 7
RT-PCR 9
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase krt14    NEW 
Molecular
reagents
All nucleic(125) Genomic(3) cDNA(117) Primer pair(3) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000002538 (Evidence)
Ensembl Gene Model ENSMUSG00000045545 (Evidence)
Entrez Gene 16664 (Evidence)
UniGene 439898
DFCI TC1575861
DoTS DT.101394427, DT.60141873
NIA Mouse Gene Index U051737
Consensus CDS Project CCDS25413.1
International Mouse Phenotyping Consortium Status Krt14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002538 VEGA Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
transcript OTTMUST00000004962 VEGA | MGI Sequence Detail 1698 Not Applicable 
polypeptide OTTMUSP00000002389 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
InterPro IPR009053 Prefoldin
Protein Ontology PR:000009454 keratin, type I cytoskeletal 14
References
(Earliest) J:30054 Knapp B, et al., Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. J Biol Chem. 1987 Jan 15;262(2):938-45
(Latest) J:219800 Lungova V, et al., Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82
All references(329)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11632, MGD-MRK-11643, MGI:2144242

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory