Krt14
Gene Detail

Symbol Name ID

Krt14 keratin 14 MGI:96688

Synonyms

Cytokeratin 14, epidermolysis bullosa simplex, Dowling-Meara, Koebner, K14, Krt-1.14, Krt1-14

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.43 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr11:100203162-100207548 bp, - strand From VEGA annotation of GRCm38   4387 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Krt14

Human homologs

Human Homolog		KRT14, keratin 14
NCBI Gene ID		3861
neXtProt AC		NX_P02533
Human Synonyms		CK14, EBS3, EBS4, K14, NFJ
Human Chr (Location)		17q12-q21; chr17:39738531-39743147 (-)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human KRT14

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Homozygotes for targeted null mutations develop extensive skin blistering after birth and die by 2 days of age. If keratin 16 is also expressed in skin, development is normal but later alopecia, chronic skin ulcers and stratified epithelial defects occur.

 
Human Diseases Modeled Using Mouse Krt14 (2)    Alleles Annotated to Human Diseases(3)    Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	epithelial cell differentiation, intermediate filament bundle assembly
Component	cell periphery, cytoplasm, ...
Function	protein binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (199 records)
Data Summary: Results (202)    Tissues (55)    Images (90)
Theiler Stages: 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	108
RNA in situ	80
Western blot	6
RT-PCR	8

cDNA source data(113)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(122) Genomic(3) cDNA(115) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000002538 (Evidence)
Ensembl Gene Model	ENSMUSG00000045545 (Evidence)
Entrez Gene	16664 (Evidence)
UniGene	439898
DFCI	TC1575861
DoTS	DT.101394427, DT.60141873
NIA Mouse Gene Index	U051737
Consensus CDS Project	CCDS25413.1
International Mouse Knockout Project Status	Krt14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002538	VEGA Gene Model | MGI Sequence Detail	4387	C57BL/6J
transcript	OTTMUST00000004962	VEGA | MGI Sequence Detail	1698	Not Applicable
polypeptide	OTTMUSP00000002389	VEGA | MGI Sequence Detail	484	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
InterPro	IPR009053	Prefoldin
Protein Ontology	PR:000009454	keratin, type I cytoskeletal 14

References

(Earliest) J:30054 Knapp B, et al., Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. J Biol Chem. 1987 Jan 15;262(2):938-45
(Latest) J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All references(268)

Other accession IDs

MGD-MRK-11632, MGD-MRK-11643, MGI:2144242