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Itgb2 Gene Detail
Summary
  • Symbol
    Itgb2
  • Name
    integrin beta 2
  • Synonyms
    2E6, Cd18, Mac-1 beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96611
    NCBI Gene: 16414
  • Gene Overview
    MyGene.info: ITGB2
Location & Maps
more
  • Sequence Map
    Chr10:77530252-77565708 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      35457 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITGB2, integrin subunit beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
  • Links
    NCBI Gene ID: 3689
    neXtProt AC: NX_P05107

  • Chr Location
    21q22.3; chr21:44885949-44928873 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Itgb2 mouse models; 1 with human ITGB2 associations

Human Disease Mouse Models
       Leukocyte Adhesion Deficiency, Type I; LAD   OMIM: 116920 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 5 alleles in 13 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 images
    161 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    9
  • Genomic Mutations
    4 involving Itgb2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    252
  • Tissues
    190
  • cDNA Data
    41
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019985 VEGA Gene Model | MGI Sequence Detail 35457 C57BL/6J ±  kb
transcript OTTMUST00000047620 VEGA | MGI Sequence Detail 2970 Not Applicable  
polypeptide OTTMUSP00000021575 VEGA | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    204 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 13
    cDNA 43
    Primer pair 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11490, MGD-MRK-1832, MGI:2143637
References
more
  • Summaries
    All 250
    Developmental Gene Expression 9
    Diseases 4
    Gene Ontology 15
    Phenotypes 161
  • Earliest
    J:30962 Sanchez-Madrid F, et al., Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1;158(2):586-602
  • Latest
    J:234730 Joshi N, et al., Fibrin deposition following bile duct injury limits fibrosis through an alphaMbeta2-dependent mechanism. Blood. 2016 Jun 2;127(22):2751-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory