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Itgb2
Gene Detail
 Symbol
Name
ID
Itgb2
integrin beta 2
MGI:96611
Synonyms 2E6, Cd18, Mac-1 beta
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr10:77530252-77565708 bp, + strand
From VEGA annotation of GRCm38

  35457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb2

Human
homologs
Human Homolog ITGB2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCBI Gene ID 3689
neXtProt AC  NX_P05107
Human Synonyms  CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Human Chr (Location)  21q22.3; chr21:44885949-44928838 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Genomic Mutations involving Itgb2 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.
 
Human Diseases Modeled Using Mouse Itgb2 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)
Interactions
Itgb2 interacts with 98 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process activated T cell proliferation, cell adhesion, ...
Component cell surface, extracellular vesicular exosome, ...
Function cell adhesion molecule binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (212)    Tissues (171)    Images (6)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 143
RT-PCR 69
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(13) cDNA(43) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019985 (Evidence)
Ensembl Gene ModelENSMUSG00000000290 (Evidence)
Entrez Gene16414 (Evidence)
UniGene1137
DFCITC1577416
DoTSDT.101328595, DT.110611815, DT.532239
Consensus CDS ProjectCCDS23956.1
International Mouse Knockout Project StatusItgb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019985 VEGA Gene Model | MGI Sequence Detail 35457 C57BL/6J ±  kb
transcript OTTMUST00000047620 VEGA | MGI Sequence Detail 2970 Not Applicable 
polypeptide OTTMUSP00000021575 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015439 Integrin beta-2 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000002041 integrin beta-2
References (Earliest) J:30962 Sanchez-Madrid F, et al., Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1;158(2):586-602
(Latest) J:210179 Zhang H, et al., STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 3;123(14):2238-49
All references(242)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11490, MGD-MRK-1832, MGI:2143637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory