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Itgb2 Gene Detail
Summary
  • Symbol
    Itgb2
  • Name
    integrin beta 2
  • Synonyms
    2E6, Cd18, Mac-1 beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96611
    NCBI Gene: 16414
  • Gene Overview
    MyGene.info: ITGB2
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77366164-77401542 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96611
 protein coding gene Chr10:77366086-77401542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017398
 protein coding gene Chr10:77850882-77900452 (+)
A/J MGP_AJ_G0017375
 protein coding gene Chr10:75150531-75185900 (+)
AKR/J MGP_AKRJ_G0017336
 protein coding gene Chr10:77156402-77193438 (+)
BALB/cJ MGP_BALBcJ_G0017335
 protein coding gene Chr10:75345523-75381087 (+)
C3H/HeJ MGP_C3HHeJ_G0017159
 protein coding gene Chr10:77241326-77277394 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017793
 protein coding gene Chr10:80581140-80616577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015483
 protein coding gene Chr10:71580863-71617746 (+)
CAST/EiJ MGP_CASTEiJ_G0016729
 protein coding gene Chr10:77591770-77634710 (+)
CBA/J MGP_CBAJ_G0017131
 protein coding gene Chr10:83703545-83740707 (+)
DBA/2J MGP_DBA2J_G0017236
 protein coding gene Chr10:74429455-74464808 (+)
FVB/NJ MGP_FVBNJ_G0017228
 protein coding gene Chr10:73602466-73639583 (+)
LP/J MGP_LPJ_G0017309
 protein coding gene Chr10:78326703-78363655 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017257
 protein coding gene Chr10:85735818-85774198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017832
 protein coding gene Chr10:77235749-77273103 (+)
PWK/PhJ MGP_PWKPhJ_G0016513
 protein coding gene Chr10:74308380-74344595 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016296
 protein coding gene Chr10:76497447-76532502 (+)
WSB/EiJ MGP_WSBEiJ_G0016792
 protein coding gene Chr10:77209714-77246355 (+)



Homology
more
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB2, integrin subunit beta 2
  • Synonyms
    CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
  • Links
    NCBI Gene ID: 3689
    neXtProt AC: NX_P05107
    UniProt: P05107

  • Chr Location
    21q22.3; chr21:44885949-44928873 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Itgb2 mouse models; 1 with human ITGB2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 9 alleles in 17 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 images
    200 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    190
  • cDNA Data
    42
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16414 NCBI Gene Model | MGI Sequence Detail 35379 C57BL/6J ±  kb
    transcript NM_008404 RefSeq | MGI Sequence Detail 2874 C57BL/6  
    polypeptide P11835 UniProt | EBI | MGI Sequence Detail 771 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 13
      cDNA 44
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11490, MGD-MRK-1832, MGI:2143637
    References
    more
    • Summaries
      All 380
      Developmental Gene Expression 13
      Diseases 7
      Gene Ontology 21
      Phenotypes 200
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:305404 Bailey WP, et al., Frontline Science: The expression of integrin alphaD beta2 (CD11d/CD18) on neutrophils orchestrates the defense mechanism against endotoxemia and sepsis. J Leukoc Biol. 2021 May;109(5):877-890
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/12/2021
    MGI 6.17     		The Jackson Laboratory