Itgb2
Gene Detail

Symbol

Name
ID

Itgb2
integrin beta 2
MGI:96611

Synonyms

2E6, Cd18, Mac-1 beta

Feature Type

protein coding gene

Genetic Map

Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr10:77530252-77565708 bp, + strand From VEGA annotation of GRCm38   35457 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb2

Human
homologs

Human Homolog		ITGB2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCBI Gene ID		3689
neXtProt AC		NX_P05107
Human Synonyms		CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Human Chr (Location)		21q22.3; chr21:44885949-44928838 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ITGB2

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Genomic Mutations involving Itgb2 (3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.

 
Human Diseases Modeled in Mice Using Itgb2 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(6)

Interactions

Itgb2 interacts with 98 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (46 annotations)

Process	activated T cell proliferation, cell adhesion, ...
Component	cell surface, extracellular vesicular exosome, ...
Function	cell adhesion molecule binding, glycoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (212)    Tissues (171)    Images (6)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	143
RT-PCR	69

cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(60) Genomic(13) cDNA(43) Primer pair(4)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000019985 (Evidence)
Ensembl Gene Model	ENSMUSG00000000290 (Evidence)
Entrez Gene	16414 (Evidence)
UniGene	1137
DFCI	TC1577416
DoTS	DT.101328595, DT.110611815, DT.532239
Consensus CDS Project	CCDS23956.1
International Mouse Knockout Project Status	Itgb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019985	VEGA Gene Model | MGI Sequence Detail	35457	C57BL/6J
transcript	OTTMUST00000047620	VEGA | MGI Sequence Detail	2970	Not Applicable
polypeptide	OTTMUSP00000021575	VEGA | MGI Sequence Detail	770	Not Applicable

All sequences(50) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(2) : SNPs within 2kb(205 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR015439	Integrin beta-2 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000002041	integrin beta-2

References

(Earliest) J:30962 Sanchez-Madrid F, et al., Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1;158(2):586-602
(Latest) J:216775 Leon-Rico D, et al., Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow. Stem Cells. 2014 Oct;32(10):2794-8
All references(244)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-11490, MGD-MRK-1832, MGI:2143637