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Itgb2
Gene Detail
Symbol

Name
ID
Itgb2
integrin beta 2
MGI:96611
Synonyms
2E6, Cd18, Mac-1 beta
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr10:77530252-77565708 bp, + strand
From VEGA annotation of GRCm38

  35457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGB2
Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb2

Human
homologs
ITGB2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3689
neXtProt AC: NX_P05107

Human Synonyms: CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7

Human Chr (Location): 21q22.3; chr21:44885949-44928873 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ITGB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(9)
Genomic Mutations involving Itgb2 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null and hypomorphic mutations are subject to granulocytosis, impaired inflammatory and immune responses, and chronic dermatitis.
 
Human Diseases Modeled in Mice Using Itgb2 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(6)
Interactions
Itgb2 interacts with 98 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process activated T cell proliferation, cell adhesion, ...
Component cell surface, extracellular exosome, ...
Function cell adhesion molecule binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (252)    Tissues (190)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RNA in situ 143
RT-PCR 71
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ITGB2 ; Xenbase itgb2    NEW 
Molecular
reagents
All nucleic(62) Genomic(13) cDNA(43) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019985 (Evidence)
Ensembl Gene Model ENSMUSG00000000290 (Evidence)
Entrez Gene 16414 (Evidence)
UniGene 1137
DFCI TC1577416
DoTS DT.101328595, DT.110611815, DT.532239
Consensus CDS Project CCDS23956.1
International Mouse Phenotyping Consortium Status Itgb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019985 VEGA Gene Model | MGI Sequence Detail 35457 C57BL/6J ±  kb
transcript OTTMUST00000047620 VEGA | MGI Sequence Detail 2970 Not Applicable 
polypeptide OTTMUSP00000021575 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015439 Integrin beta-2 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000002041 integrin beta-2
References
(Earliest) J:30962 Sanchez-Madrid F, et al., Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med. 1983 Aug 1;158(2):586-602
(Latest) J:219405 Wu X, et al., T Cell-Extrinsic CD18 Attenuates Antigen-Dependent CD4+ T Cell Activation In Vivo. J Immunol. 2015 Mar 23;
All references(242)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11490, MGD-MRK-1832, MGI:2143637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory