Il13
Gene Detail

Symbol Name ID

Il13 interleukin 13 MGI:96541

Synonyms

Il-13

Feature Type

protein coding gene

Genetic Map

Chromosome 11

31.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr11:53631324-53634702 bp, - strand From VEGA annotation of GRCm38   3379 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-13
Gene Tree: Il13

Human homologs

Human Homolog		IL13, interleukin 13
NCBI Gene ID		3596
neXtProt AC		NX_P35225
Human Synonyms		IL-13, P600
Human Chr (Location)		5q31; chr5:131993865-131996801 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL13

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular response to cytokine stimulus, immune response, ...
Component	cytoplasm, external side of plasma membrane, ...
Function	cytokine activity, cytokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (21)   
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	29

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(7) cDNA(4) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005641 (Evidence)
Ensembl Gene Model	ENSMUSG00000020383 (Evidence)
Entrez Gene	16163 (Evidence)
UniGene	1284
DFCI	TC1594792
DoTS	DT.40185531
NIA Mouse Gene Index	U032766
Consensus CDS Project	CCDS24683.1
International Mouse Knockout Project Status	Il13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005641	VEGA Gene Model | MGI Sequence Detail	3379	C57BL/6J
transcript	OTTMUST00000012549	VEGA | MGI Sequence Detail	1205	Not Applicable
polypeptide	OTTMUSP00000005816	VEGA | MGI Sequence Detail	131	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR020470	Interleukin-13
InterPro	IPR001325	Interleukin-4/interleukin-13
InterPro	IPR018096	Interleukin-4/interleukin-13, conserved site
Protein Ontology	PR:000001370	interleukin-13

References

(Earliest) J:20635 Brown KD, et al., A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J Immunol. 1989 Jan 15;142(2):679-87
(Latest) J:195790 Sawada M, et al., IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13. PLoS One. 2013;8(1):e54623
All references(228)

Other accession IDs

MGD-MRK-11350, MGD-MRK-11365