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Il13
Gene Detail
Symbol

Name
ID
Il13
interleukin 13
MGI:96541
Synonyms
Il-13
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:53631324-53634702 bp, - strand
From VEGA annotation of GRCm38

  3379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL13
Protein SuperFamily: interleukin-13
Gene Tree: Il13

Human
homologs
IL13, interleukin 13
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3596
neXtProt AC: NX_P35225

Human Synonyms: IL-13, P600

Human Chr (Location): 5q31; chr5:132658173-132661109 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IL13

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(14) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
 
Human Diseases Modeled in Mice Using Il13 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Il13 interacts with 141 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to cytokine stimulus, immune response, ...
Component cytoplasm, external side of plasma membrane, ...
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 29
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(7) cDNA(4) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005641 (Evidence)
Ensembl Gene Model ENSMUSG00000020383 (Evidence)
Entrez Gene 16163 (Evidence)
UniGene 1284
DFCI TC1594792
DoTS DT.40185531
NIA Mouse Gene Index U032766
Consensus CDS Project CCDS24683.1
International Mouse Phenotyping Consortium Status Il13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005641 VEGA Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
transcript OTTMUST00000012549 VEGA | MGI Sequence Detail 1205 Not Applicable 
polypeptide OTTMUSP00000005816 VEGA | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR020470 Interleukin-13
InterPro IPR001325 Interleukin-4/interleukin-13
InterPro IPR018096 Interleukin-4/interleukin-13, conserved site
Protein Ontology PR:000001370 interleukin-13
References
(Earliest) J:20635 Brown KD, et al., A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J Immunol. 1989 Jan 15;142(2):679-87
(Latest) J:222287 Cheng LE, et al., IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6;212(4):513-24
All references(245)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11350, MGD-MRK-11365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory