About   Help   FAQ
Il13
Gene Detail
Symbol

Name
ID
Il13
interleukin 13
MGI:96541
Synonyms
Il-13
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:53631324-53634702 bp, - strand
From VEGA annotation of GRCm38

  3379 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-13
Gene Tree: Il13

Human
homologs
Human Homolog IL13, interleukin 13
NCBI Gene ID 3596
neXtProt AC  NX_P35225
Human Synonyms  IL-13, P600
Human Chr (Location)  5q31; chr5:132658173-132661109 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL13
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(14)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
 
Interactions
Il13 interacts with 141 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cellular response to cytokine stimulus, immune response, ...
Component cytoplasm, external side of plasma membrane, ...
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 29
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(7) cDNA(4) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005641 (Evidence)
Ensembl Gene ModelENSMUSG00000020383 (Evidence)
Entrez Gene16163 (Evidence)
UniGene1284
DFCITC1594792
DoTSDT.40185531
NIA Mouse Gene IndexU032766
Consensus CDS ProjectCCDS24683.1
International Mouse Knockout Project StatusIl13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005641 VEGA Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
transcript OTTMUST00000012549 VEGA | MGI Sequence Detail 1205 Not Applicable 
polypeptide OTTMUSP00000005816 VEGA | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR020470 Interleukin-13
InterPro IPR001325 Interleukin-4/interleukin-13
InterPro IPR018096 Interleukin-4/interleukin-13, conserved site
Protein Ontology PR:000001370 interleukin-13
References
(Earliest) J:20635 Brown KD, et al., A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J Immunol. 1989 Jan 15;142(2):679-87
(Latest) J:210323 Van Dyken SJ, et al., Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity. 2014 Mar 20;40(3):414-24
All references(242)
Other
accession IDs
MGD-MRK-11350, MGD-MRK-11365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory