Igf1
Gene Detail

Symbol Name ID

Igf1 insulin-like growth factor 1 MGI:96432

Synonyms

C730016P09Rik, Igf-1, Igf-I

Feature Type

protein coding gene

Genetic Map

Chromosome 10

43.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)

Sequence Map

Chr10:87858265-87937042 bp, + strand From VEGA annotation of GRCm38   78778 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin-like growth factor 1
Gene Tree: Igf1

Human homologs

Human Homolog		IGF1, insulin-like growth factor 1 (somatomedin C)
NCBI Gene ID		3479
neXtProt AC		NX_P05019
Human Synonyms		IGF1A, IGFI, IGF-I
Human Chr (Location)		12q23.2; chr12:102789645-102874378 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IGF1

Alleles and phenotypes

All alleles(22) : Targeted(12) Gene trapped(10)
 

Homozygous null mutants are severely growth retarded and die perinatally with many immature organ systems. Heterozygotes and partial knockouts show genetic background effects and can display growth retardation and abnormalities in muscle, lungs, and CNS.

 
Human Diseases Modeled Using Mouse Igf1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (111 annotations)

Process	blood vessel remodeling, bone mineralization involved in bone maturation, ...
Component	extracellular region, extracellular space, ...
Function	growth factor activity, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (82 records)
Data Summary: Results (333)    Tissues (252)    Images (44)
Theiler Stages: 2, 3, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	226
Northern blot	5
Western blot	15
RT-PCR	87

cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(3) cDNA(31) Primer pair(16)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000031391 (Evidence)
Ensembl Gene Model	ENSMUSG00000020053 (Evidence)
Entrez Gene	16000 (Evidence)
DFCI	TC1580490, TC1588155, TC1589959, TC1592096, TC1593965, TC1597209
DoTS	DT.101725600, DT.110582529, DT.110582532, DT.40181304, DT.87050958, DT.91445212, DT.94340457
NIA Mouse Gene Index	U011850
Consensus CDS Project	CCDS24103.1, CCDS24104.2, CCDS48661.1, CCDS48662.1, CCDS48663.1
International Mouse Knockout Project Status	Igf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031391	VEGA Gene Model | MGI Sequence Detail	78778	C57BL/6J
transcript	OTTMUST00000077782	VEGA | MGI Sequence Detail	2292	Not Applicable
polypeptide	OTTMUSP00000041215	VEGA | MGI Sequence Detail	165	Not Applicable

All sequences(83) RefSeq(10) UniProt(8)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(258 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
InterPro	IPR022350	Insulin-like growth factor
InterPro	IPR022341	Insulin-like growth factor I
Protein Ontology	PR:000009182	insulin-like growth factor I

References

(Earliest) J:30357 Schoenle E, et al., Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature. 1982 Mar 18;296(5854):252-3
(Latest) J:193782 Sheng MH, et al., Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice. Bone. 2013 Jan;52(1):133-44
All references(405)

Other accession IDs

MGD-MRK-11226, MGD-MRK-11228, MGI:2444166