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Igf1 Gene Detail
Summary
  • Symbol
    Igf1
  • Name
    insulin-like growth factor 1
  • Synonyms
    C730016P09Rik, Igf-1, Igf-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:96432
    NCBI Gene: 16000
  • Gene Overview
    MyGene.info: IGF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:87858265-87937042 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78778 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 43.70 cM
  • Mapping Data
    32 experiments
Homology
more
  • Human Ortholog
    IGF1, insulin like growth factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGF1, insulin like growth factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGF, IGFI, IGF-I, MGF
  • Links
    NCBI Gene ID: 3479
    neXtProt AC: NX_P05019
    UniProt: P05019

  • Chr Location
    12q23.2; chr12:102395867-102481839 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 9 alleles in 12 genetic backgrounds
    124 phenotypes from multigenic genotypes
    1 images
    202 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are severely growth retarded and die perinatally with many immature organ systems. Heterozygotes and partial knockouts show genetic background effects and can display growth retardation and abnormalities in muscle, lungs, and CNS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031391 VEGA Gene Model | MGI Sequence Detail 78778 C57BL/6J ±  kb
    transcript OTTMUST00000077782 VEGA | MGI Sequence Detail 2292 Not Applicable  
    polypeptide OTTMUSP00000041215 VEGA | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      280 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 3
      cDNA 34
      Primer pair 16

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11226, MGD-MRK-11228, MGI:2444166
    References
    more
    • Summaries
      All 645
      Developmental Gene Expression 116
      Diseases 1
      Gene Ontology 39
      Phenotypes 202
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264830 Guo C, et al., IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades. Sci Rep. 2018 Feb 1;8(1):2054

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory