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Gene Detail
insulin-like growth factor 1
Synonyms C730016P09Rik, Igf-1, Igf-I
Feature Type protein coding gene
Genetic Map
Chromosome 10
43.70 cM
Detailed Genetic Map ± 1 cM

Mapping data(32)
Sequence Map
Chr10:87858265-87937042 bp, + strand
From VEGA annotation of GRCm38

  78778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: insulin-like growth factor 1
Gene Tree: Igf1

Human Homolog IGF1, insulin-like growth factor 1 (somatomedin C)
NCBI Gene ID 3479
neXtProt AC  NX_P05019
Human Synonyms  IGF1A, IGFI, IGF-I
Human Chr (Location)  12q23.2; chr12:102395867-102480600 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGF1
alleles, and
All mutations/alleles(22) : Gene trapped(10) Targeted(12)
Homozygous null mutants are severely growth retarded and die perinatally with many immature organ systems. Heterozygotes and partial knockouts show genetic background effects and can display growth retardation and abnormalities in muscle, lungs, and CNS.
Human Diseases Modeled Using Mouse Igf1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Igf1 interacts with 493 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (119 annotations)
Process blood vessel remodeling, bone mineralization involved in bone maturation, ...
Component extracellular region, extracellular space, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Literature Summary: (88 records)
Data Summary: Results (338)    Tissues (252)    Images (48)
Theiler Stages: 2, 3, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 226
Northern blot 5
Western blot 15
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(50) Genomic(3) cDNA(31) Primer pair(16)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000031391 (Evidence)
Ensembl Gene ModelENSMUSG00000020053 (Evidence)
Entrez Gene16000 (Evidence)
DFCITC1580490, TC1588155, TC1589959, TC1592096, TC1593965, TC1597209
DoTSDT.101725600, DT.110582529, DT.110582532, DT.40181304, DT.87050958, DT.91445212, DT.94340457
NIA Mouse Gene IndexU011850
Consensus CDS ProjectCCDS24103.1, CCDS24104.2, CCDS48661.1, CCDS48662.1, CCDS48663.1
International Mouse Knockout Project StatusIgf1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031391 VEGA Gene Model | MGI Sequence Detail 78778 C57BL/6J ±  kb
transcript OTTMUST00000077782 VEGA | MGI Sequence Detail 2292 Not Applicable 
polypeptide OTTMUSP00000041215 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(38) UniProt(8)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(281 from dbSNP Build 137)
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
InterPro IPR022350 Insulin-like growth factor
InterPro IPR022341 Insulin-like growth factor I
Protein Ontology PR:000009182 insulin-like growth factor I
References (Earliest) J:30357 Schoenle E, et al., Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature. 1982 Mar 18;296(5854):252-3
(Latest) J:210636 Levine ME, et al., Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 4;19(3):407-17
All references(423)
accession IDs
MGD-MRK-11226, MGD-MRK-11228, MGI:2444166

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory