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Igf1
Gene Detail
Symbol

Name
ID
Igf1
insulin-like growth factor 1
MGI:96432
Synonyms
C730016P09Rik, Igf-1, Igf-I
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr10:87858265-87937042 bp, + strand
From VEGA annotation of GRCm38

  78778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IGF1
Protein SuperFamily: insulin-like growth factor 1
Gene Tree: Igf1

Human
homologs
IGF1, insulin-like growth factor 1 (somatomedin C)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3479
neXtProt AC: NX_P05019

Human Synonyms: IGF1A, IGFI, IGF-I

Human Chr (Location): 12q23.2; chr12:102395867-102481786 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IGF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(10) Targeted(12) Transgenic(3)
 
Homozygous null mutants are severely growth retarded and die perinatally with many immature organ systems. Heterozygotes and partial knockouts show genetic background effects and can display growth retardation and abnormalities in muscle, lungs, and CNS.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Igf1 interacts with 492 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (139 annotations)
Process activation of protein kinase activity, blood vessel remodeling, ...
Component cytoplasm, extracellular region, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (92 records)
Data Summary: Results (338)    Tissues (254)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 226
Northern blot 5
Western blot 15
RT-PCR 82
cDNA source data(29)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA IGF1 ZFIN igf1    NEW 
Molecular
reagents
All nucleic(50) Genomic(3) cDNA(31) Primer pair(16)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000031391 (Evidence)
Ensembl Gene Model ENSMUSG00000020053 (Evidence)
Entrez Gene 16000 (Evidence)
DFCI TC1580490, TC1588155, TC1589959, TC1592096, TC1593965, TC1597209
DoTS DT.101725600, DT.110582529, DT.110582532, DT.40181304, DT.87050958, DT.91445212, DT.94340457
NIA Mouse Gene Index U011850
Consensus CDS Project CCDS24103.1, CCDS24104.2, CCDS48661.1, CCDS48662.1, CCDS48663.1
International Mouse Phenotyping Consortium Status Igf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031391 VEGA Gene Model | MGI Sequence Detail 78778 C57BL/6J ±  kb
transcript OTTMUST00000077782 VEGA | MGI Sequence Detail 2292 Not Applicable 
polypeptide OTTMUSP00000041215 VEGA | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(34) UniProt(8)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(281 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
InterPro IPR022350 Insulin-like growth factor
InterPro IPR022341 Insulin-like growth factor I
Protein Ontology PR:000009182 insulin-like growth factor I
References
(Earliest) J:30357 Schoenle E, et al., Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature. 1982 Mar 18;296(5854):252-3
(Latest) J:220467 Galvis LA, et al., Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015 Apr 15;142(8):1458-69
All references(432)
Other
accession IDs
MGD-MRK-11226, MGD-MRK-11228, MGI:2444166

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory