85 phenotypes from 9 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Igf1tm1.1Dlr/Igf1tm1.1Dlr involves: C57BL/6 * FVB/N	abnormal body size	J:69518
	abnormal glucose homeostasis	J:69518
	decreased birth weight	J:69518
	decreased body length	J:69518
	decreased circulating glucose level	J:69518
	increased circulating growth hormone level	J:69518
	increased circulating insulin level	J:69518
	insensitivity to growth hormone	J:69518
	postnatal lethality, incomplete penetrance	J:69518
	premature death	J:49468
	prenatal lethality, incomplete penetrance	J:69518
	slow postnatal weight gain	J:49468, J:69518
Igf1tm1.1Nros/Igf1tm1.1Nros involves: BALB/c * C57BL/6	decreased circulating insulin-like growth factor I level	J:159167
	normal growth/size/body region phenotype	J:159167
	normal mortality/aging	J:159167
Igf1tm1Arge/Igf1+ involves: 129S/SvEv * MF1	normal hearing/vestibular/ear phenotype	J:105536
	small cochlear ganglion	J:71687
Igf1tm1Arge/Igf1tm1Arge either: 129S/SvEv-Igf1tm1Arge or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	decreased body size	J:15108
	delayed bone ossification	J:15108
	neonatal lethality, complete penetrance	J:15108
	postnatal growth retardation	J:15108
Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv	decreased motor neuron number	J:103711
Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv * DBA * MF1	abnormal chondrocyte morphology	J:66913
	abnormal long bone epiphyseal plate proliferative zone	J:66913
	abnormal long bone hypertrophic chondrocyte zone	J:66913
	abnormal trabecular bone morphology	J:66913
	decreased width of hypertrophic chondrocyte zone	J:66913
	delayed endochondral bone ossification	J:66913
	increased circulating growth hormone level	J:66913
	postnatal growth retardation	J:66913
	proportional dwarf	J:66913
Igf1tm1Arge/Igf1tm1Arge involves: 129S/SvEv * MF1	abnormal auditory brainstem response waveform shape	J:105536
	abnormal cochlea morphology	J:71687
	abnormal cochlear ganglion morphology	J:71687
	abnormal cochlear nerve morphology	J:71687
	abnormal hair follicle development	J:82113
	abnormal lung morphology	J:82113
	abnormal mitral cell morphology	J:82113
	abnormal myelination	J:71687
	abnormal olfactory bulb external plexiform layer morphology	J:82113
	abnormal olfactory bulb layer morphology	J:82113
	abnormal olfactory bulb mitral cell layer morphology	J:82113
	abnormal otic capsule morphology	J:71687
	abnormal sensory neuron innervation pattern	J:71687
	abnormal skeleton morphology	J:82113
	abnormal tectorial membrane morphology	J:71687
	cochlear ganglion degeneration	J:71687
	decreased body weight	J:71687, J:82113
	delayed bone ossification	J:82113
	delayed inner ear development	J:71687
	disproportionate dwarf	J:71687
	increased neuron apoptosis	J:71687
	increased or absent threshold for auditory brainstem response	J:105536
	increased type II pneumocyte number	J:82113
	muscle hypoplasia	J:82113
	postnatal growth retardation	J:71687
	postnatal lethality, incomplete penetrance	J:82113, J:105536
	sensorineural hearing loss	J:105536
	small cochlear ganglion	J:71687
	syndromic hearing loss	J:105536
Igf1tm1Dlr/Igf1tm1Dlr Tg(Alb1-cre)1Dlr/0 involves: 129/Sv * C57BL/6 * FVB/N	no abnormal phenotype detected	J:69517
Igf1tm1Dlr/Igf1tm1Dlr Tg(Alb1-cre)1Dlr/0 involves: 129/Sv * C57BL/6J * FVB/N	decreased circulating insulin-like growth factor I level	J:155733
	decreased tumor growth/size	J:155733
	increased circulating leptin level	J:155733
Igf1tm1Dlr/Igf1tm1Dlr Tg(EIIa-cre)C5379Lmgd/0 involves: 129/Sv * C57BL/6 * FVB/N	fetal growth retardation	J:49468
	perinatal lethality, incomplete penetrance	J:49468
	slow postnatal weight gain	J:49468
Igf1tm1Dlr/Igf1tm1Dlr Tg(Mx1-cre)1Cgn/0 involves: 129/Sv * C57BL/6 * CBA	decreased circulating insulin-like growth factor I level	J:55718, J:121798
	decreased kidney weight	J:121798
	normal growth/size/body region phenotype	J:55718, J:121798
	normal homeostasis/metabolism phenotype	J:121798
	increased circulating growth hormone level	J:121798
	increased systemic arterial systolic blood pressure	J:121798
	increased urine potassium level	J:121798
	increased urine sodium level	J:121798
	normal renal/urinary system phenotype	J:121798
Igf1tm1Dlr/Igf1tm1Dlr Tg(Serpina1e-cre/ERT)1Sykr/0 involves: 129/Sv * C57BL/6J * FVB/N	decreased circulating insulin-like growth factor I level	J:155733
	normal homeostasis/metabolism phenotype	J:155733
	increased circulating insulin level	J:155733
	increased circulating leptin level	J:155733
	normal neoplasm	J:155733
Igf1tm1Ts/Igf1+ involves: 129S7/SvEvBrd * C57BL/6J	abnormal postnatal growth/weight/body size	J:16214
Igf1tm1Ts/Igf1tm1Ts involves: 129S7/SvEvBrd * C57BL/6J	abnormal brain morphology	J:24953
	abnormal embryonic growth/weight/body size	J:16214
	abnormal muscle morphology	J:16214
	abnormal nervous system physiology	J:24953
	abnormal respiratory system morphology	J:16214
	abnormal respiratory system physiology	J:16214
	perinatal lethality	J:16214
Igf1tm2.1Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA	decreased body weight	J:142247
	decreased circulating insulin-like growth factor I level	J:142247
Igf1tm2.1Nros/Igf1+ involves: BALB/c * C57BL/6	decreased birth weight	J:159167
Igf1tm2.1Nros/Igf1tm2.1Nros involves: BALB/c * C57BL/6	abnormal lung morphology	J:159167
	decreased birth weight	J:159167
	neonatal lethality, complete penetrance	J:159167
	primary atelectasis	J:159167
	respiratory failure	J:159167
Igf1tm2Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA	decreased body weight	J:142247
	decreased circulating insulin-like growth factor I level	J:142247
Igf1tm2Arge/Igf1tm2.1Arge Tg(SERPINA1-cre)1Arge/0 involves: 129S/SvEv * C57BL/6J * CBA	decreased body weight	J:142247
	decreased circulating insulin-like growth factor I level	J:142247
Igf1tm2Arge/Igf1tm2Arge involves: 129S/SvEv * C57BL/6J	abnormal long bone epiphyseal plate proliferative zone	J:142247
	decreased body weight	J:142247
	decreased circulating insulin-like growth factor I level	J:142247
	decreased long bone epiphyseal plate size	J:142247
	decreased survivor rate	J:142247
	infertility	J:142247
	neonatal lethality, incomplete penetrance	J:142247
	postnatal growth retardation	J:142247
Igf1tm2Arge/Igf1tm2Arge Tg(SERPINA1-cre)1Arge/0 involves: 129S/SvEv * C57BL/6J	decreased body weight	J:142247
	decreased circulating insulin-like growth factor I level	J:142247
	decreased survivor rate	J:142247
	neonatal lethality, incomplete penetrance	J:142247
	normal reproductive system phenotype	J:142247
Igf1tm2Ts/Igf1tm2Ts involves: 129S7/SvEvBrd * C57BL/6J	decreased body weight	J:37969
	decreased circulating glucose level	J:37969
	decreased circulating growth hormone level	J:37969
	increased systemic arterial blood pressure	J:37969
	increased systemic arterial diastolic blood pressure	J:37969
	increased systemic arterial systolic blood pressure	J:37969
	increased ventricle muscle contractility	J:37969