Igf1^tm2.1Arge
Targeted Allele Detail

Summary

• Symbol: Igf1^tm2.1Arge
• Name: insulin-like growth factor 1; targeted mutation 2.1, Argiris Efstratiadis
• MGI ID: MGI:3821756
• Synonyms: Igf1^deltaflox
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm2.1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142247
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove the puromycin resistance cassette and SV40 polyadenylation sequence to allow for expression of the full-length cDNA. (J:142247)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 27 strains or lines available

References

• Original: J:142247 Stratikopoulos E, et al., The hormonal action of IGF1 in postnatal mouse growth. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83
• All: 1 reference(s)