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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igf1tm2.1Arge
targeted mutation 2.1, Argiris Efstratiadis
MGI:3821756
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igf1tm2.1Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA MGI:3821762
ht2
 		Igf1tm2Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA MGI:3821764
cn3
 		Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J * CBA MGI:3821763


Genotype
MGI:3821762
hm1
Allelic
Composition		 Igf1tm2.1Arge/Igf1tm2.1Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 70% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 29% of normal
• at P72, IGF1 serum levels are 51% of normal




Genotype
MGI:3821764
ht2
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 54% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 21% of normal
• at P72, IGF1 serum levels are 26% of normal




Genotype
MGI:3821763
cn3
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 61% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 24% of normal
• at P72, IGF1 serum levels are 60% of normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory