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Hras
Gene Detail
Symbol

Name
ID
Hras
Harvey rat sarcoma virus oncogene
MGI:96224
Synonyms
c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras1, Hras-1, ras
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr7:141189105-141194005 bp, - strand
From VEGA annotation of GRCm38

  4901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: HRAS
Protein SuperFamily: ras protein
Gene Tree: Hras

Human
homologs
HRAS, Harvey rat sarcoma viral oncogene homolog
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3265
neXtProt AC: NX_P01112

Human Synonyms: C-BAS/HAS, C-HA-RAS1, C-H-RAS, CTLO, HAMSV, HRAS1, H-RASIDX, p21ras, RASH1

Human Chr (Location): 11p15.5; chr11:532242-535561 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human HRAS

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(2) Targeted(8) Transgenic(4)
Incidental mutations (data from APF )
 
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
 
Human Diseases Modeled in Mice Using Hras (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(3)
Interactions
Hras interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process apoptotic process, cell aging, ...
Component Golgi apparatus, intracellular, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (176)    Tissues (48)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 95
Western blot 23
RT-PCR 49
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hras ; ZFIN hrasa    NEW 
Molecular
reagents
All nucleic(86) Genomic(9) cDNA(70) Primer pair(2) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016471 (Evidence)
Ensembl Gene Model ENSMUSG00000025499 (Evidence)
Entrez Gene 15461 (Evidence)
UniGene 334313
DFCI TC1580214, TC1599731, TC1613453, TC1619526, TC1685708
DoTS DT.101380088, DT.101380090, DT.534773, DT.55194301
NIA Mouse Gene Index U029447
Consensus CDS Project CCDS22003.1, CCDS52439.1
International Mouse Phenotyping Consortium Status Hras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016471 VEGA Gene Model | MGI Sequence Detail 4901 C57BL/6J ±  kb
transcript OTTMUST00000039712 VEGA | MGI Sequence Detail 2828 Not Applicable 
polypeptide OTTMUSP00000017719 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(11) UniProt(2)
Polymorphisms
RFLP(12) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000029705 GTPase HRas
References
(Earliest) J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
(Latest) J:220090 Wang AG, et al., Activation of RAS/ERK alone is insufficient to inhibit RXRalpha function and deplete retinoic acid in hepatocytes. Biochem Biophys Res Commun. 2014 Sep 26;452(3):801-7
All references(193)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10930, MGD-MRK-10931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory