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Hras Gene Detail
Summary
  • Symbol
    Hras
  • Name
    Harvey rat sarcoma virus oncogene
  • Synonyms
    c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras1, Hras-1, ras
  • Feature Type
    protein coding gene
  • IDs
    MGI:96224
    NCBI Gene: 15461
  • Gene Overview
    MyGene.info: HRAS
Location & Maps
more
  • Sequence Map
    Chr7:141189105-141194005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4901 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.48 cM
  • Mapping Data
    31 experiments
Homology
more
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C-BAS/HAS, C-HA-RAS1, C-H-RAS, CTLO, HAMSV, HRAS1, H-RASIDX, p21ras, RASH1
  • Links
    NCBI Gene ID: 3265
    neXtProt AC: NX_P01112

  • Chr Location
    11p15.5; chr11:532242-535561 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hras mouse models; 6 with human HRAS associations

Human Disease Mouse Models
       Costello Syndrome; CSTLO   OMIM: 218040 View 2 models
       Bladder Cancer   OMIM: 109800
Melanocytic Nevus Syndrome, Congenital; CMNS   OMIM: 137550
Nevus, Epidermal   OMIM: 162900
Schimmelpenning-Feuerstein-Mims Syndrome; SFM   OMIM: 163200
Thyroid Cancer, Nonmedullary, 2; NMTC2   OMIM: 188470
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 9 alleles in 11 genetic backgrounds
    38 phenotypes from multigenic genotypes
    7 images
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    10
  • Transgenic
    13
  • Genomic Mutations
    1 involving Hras
  • Incidental Mutations
    APF
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016471 VEGA Gene Model | MGI Sequence Detail 4901 C57BL/6J ±  kb
transcript OTTMUST00000039712 VEGA | MGI Sequence Detail 2828 Not Applicable  
polypeptide OTTMUSP00000017719 VEGA | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029705 GTPase HRas
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 87
    Genomic 9
    cDNA 71
    Primer pair 2
    Other 5

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10930, MGD-MRK-10931
References
more
  • Summaries
    All 199
    Developmental Gene Expression 27
    Diseases 7
    Gene Ontology 25
    Phenotypes 99
  • Earliest
    J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
  • Latest
    J:228719 Rooney GE, et al., Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 6;36(1):142-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory