About   Help   FAQ
Hras
Gene Detail
 Symbol
Name
ID
Hras
Harvey rat sarcoma virus oncogene
MGI:96224
Synonyms c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras1, Hras-1, ras
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr7:141189105-141194005 bp, - strand
From VEGA annotation of GRCm38

  4901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Hras

Human
homologs
Human Homolog HRAS, Harvey rat sarcoma viral oncogene homolog
NCBI Gene ID 3265
neXtProt AC  NX_P01112
Human Synonyms  C-BAS/HAS, C-HA-RAS1, C-H-RAS, CTLO, HAMSV, HRAS1, H-RASIDX, p21ras, RASH1
Human Chr (Location)  11p15.5; chr11:532242-535561 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human HRAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from APF )
 
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
 
Human Diseases Modeled Using Mouse Hras (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Interactions
Hras interacts with 187 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process apoptotic process, cell aging, ...
Component Golgi apparatus, intracellular, ...
Function GTP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (176)    Tissues (48)    Images (29)
Theiler Stages: 2, 3, 5, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 95
Western blot 23
RT-PCR 49
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(9) cDNA(70) Primer pair(2) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016471 (Evidence)
Ensembl Gene ModelENSMUSG00000025499 (Evidence)
Entrez Gene15461 (Evidence)
UniGene334313
DFCITC1580214, TC1599731, TC1613453, TC1619526, TC1685708
DoTSDT.101380088, DT.101380090, DT.534773, DT.55194301
NIA Mouse Gene IndexU029447
Consensus CDS ProjectCCDS22003.1, CCDS52439.1
International Mouse Knockout Project StatusHras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016471 VEGA Gene Model | MGI Sequence Detail 4901 C57BL/6J ±  kb
transcript OTTMUST00000039712 VEGA | MGI Sequence Detail 2828 Not Applicable 
polypeptide OTTMUSP00000017719 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(18) UniProt(2)
Polymorphisms RFLP(12) : SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000029705 GTPase HRas
References (Earliest) J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
(Latest) J:204891 Goodwin AF, et al., Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 1;23(3):682-92
All references(196)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10930, MGD-MRK-10931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory