Hras1
Gene Detail

Symbol Name ID

Hras1 Harvey rat sarcoma virus oncogene 1 MGI:96224

Synonyms

c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras-1, ras

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)

Sequence Map

Chr7:141189105-141194005 bp, - strand From VEGA annotation of GRCm38   4901 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Hras1

Human homologs

Human Homolog		HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
NCBI Gene ID		3265
neXtProt AC		NX_P01112
Human Synonyms		C-BAS/HAS, C-HA-RAS1, C-H-RAS, CTLO, HAMSV, HRAS1, H-RASIDX, K-RAS, N-RAS, RASH1
Human Chr (Location)		11p15.5; chr11:532242-535550 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human HRAS

Alleles and phenotypes

All alleles(10) : Targeted(8) Gene trapped(2)
 

Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.

 
Human Diseases Modeled Using Mouse Hras1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (57 annotations)

Process	apoptotic process, cell aging, ...
Component	Golgi apparatus, intracellular membrane-bounded organelle, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (176)    Tissues (48)    Images (29)
Theiler Stages: 2, 3, 5, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	95
Western blot	23
RT-PCR	49

cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) Genomic(9) cDNA(69) Primer pair(2) Other(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016471 (Evidence)
Ensembl Gene Model	ENSMUSG00000025499 (Evidence)
Entrez Gene	15461 (Evidence)
UniGene	334313
DFCI	TC1580214, TC1599731, TC1613453, TC1619526, TC1685708
DoTS	DT.101380088, DT.101380090, DT.534773, DT.55194301
NIA Mouse Gene Index	U029447
Consensus CDS Project	CCDS22003.1, CCDS52439.1
International Mouse Knockout Project Status	Hras1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016471	VEGA Gene Model | MGI Sequence Detail	4901	C57BL/6J
transcript	OTTMUST00000039712	VEGA | MGI Sequence Detail	2828	Not Applicable
polypeptide	OTTMUSP00000017719	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(54) RefSeq(6) UniProt(3)

Polymorphisms

RFLP(12) : SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR020849	Small GTPase superfamily, Ras type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000029705	GTPase HRas

References

(Earliest) J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
(Latest) J:192241 Ben Hamida S, et al., The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. J Neurosci. 2012 Nov 7;32(45):15849-58
All references(186)

Other accession IDs

MGD-MRK-10930, MGD-MRK-10931