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Hras Gene Detail
Summary
  • Symbol
    Hras
  • Name
    Harvey rat sarcoma virus oncogene
  • Synonyms
    c-H-ras, c-rasHa, Ha-ras, Harvey-ras, H-ras, Hras1, Hras-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96224
    NCBI Gene: 15461
  • Gene Overview
    MyGene.info: HRAS
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141189934-141194004 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.48 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96224
protein coding gene Chr7:141189105-141194005 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033214
protein coding gene Chr7:146365248-146370148 (-)
A/J MGP_AJ_G0033196
protein coding gene Chr7:142179696-142184596 (-)
AKR/J MGP_AKRJ_G0033128
protein coding gene Chr7:146098348-146103248 (-)
BALB/cJ MGP_BALBcJ_G0033197
protein coding gene Chr7:141920427-141925327 (-)
C3H/HeJ MGP_C3HHeJ_G0032911
protein coding gene Chr7:145855797-145860697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033708
protein coding gene Chr7:151717143-151722043 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030681
protein coding gene Chr7:143389632-143394500 (-)
CAST/EiJ MGP_CASTEiJ_G0032241
protein coding gene Chr7:138164508-138169389 (-)
CBA/J MGP_CBAJ_G0032883
protein coding gene Chr7:156841323-156846223 (-)
DBA/2J MGP_DBA2J_G0033035
protein coding gene Chr7:140127236-140132136 (-)
FVB/NJ MGP_FVBNJ_G0032988
protein coding gene Chr7:140039978-140044878 (-)
LP/J MGP_LPJ_G0033130
protein coding gene Chr7:147861594-147866494 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033021
protein coding gene Chr7:157508623-157513523 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033728
protein coding gene Chr7:145076822-145081722 (-)
PWK/PhJ MGP_PWKPhJ_G0031945
protein coding gene Chr7:133407409-133412313 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031792
protein coding gene Chr7:131901364-131907888 (-)
WSB/EiJ MGP_WSBEiJ_G0032352
protein coding gene Chr7:146025039-146029939 (-)



Homology
more
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HRAS, HRas proto-oncogene, GTPase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C-BAS/HAS, C-HA-RAS1, C-H-RAS, c-Ki-ras, c-K-ras, CTLO, HAMSV, HRAS1, H-RASIDX, Ki-Ras, KRAS, KRAS2, p21ras, RASH1, RASK2
  • Links
    NCBI Gene ID: 3265
    neXtProt AC: NX_P01112
    UniProt: P01112

  • Chr Location
    11p15.5; chr11:532242-535567 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Hras mouse models; 4 with human HRAS associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 9 alleles in 11 genetic backgrounds
    55 phenotypes from multigenic genotypes
    7 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations are viable and fertile with no gross morphological or histological abnormalities, defects in neuronal development or defects in lymphocyte cell populations. A decreased susceptibility to DMBA induced skin papillomas was also demonstrated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15461 NCBI Gene Model | MGI Sequence Detail 4071 C57BL/6J ±  kb
    transcript NM_001130444 RefSeq | MGI Sequence Detail 2272 Not Specified  
    polypeptide Q61411 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 9
      cDNA 72
      Primer pair 2
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10930, MGD-MRK-10931
    References
    more
    • Summaries
      All 343
      Developmental Gene Expression 20
      Diseases 9
      Gene Ontology 25
      Phenotypes 119
    • Earliest
      J:6408 Shih TY, et al., Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686-91
    • Latest
      J:265335 Reichenbach B, et al., Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J. 2018 May 2;37(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory