Hras Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hras
Harvey rat sarcoma virus oncogene
MGI:96224

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Tyr-cre/ERT,-Hras1,-Trap1a)10BJvde/0 involves: C57BL/6 FVB/N	increased classified tumor incidence	J:107175
	increased cutaneous melanoma incidence	J:107175
	increased neurofibrosarcoma incidence	J:107175
Hras^tm1Esn/Hras^tm1Esn Nras^tm1Rak/Nras^tm1Rak involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:67374
Hras^tm1Grnt/Hras^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺ involves: 129P2/OlaHsd * MF1	reduced long-term potentiation	J:98903
Hras^tm1Jaf/Hras^tm1Jaf Nf2^tm2Gth/Nf2^tm2Gth Tg(TPO-cre)1Shk/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Jaf/Hras^tm1Jaf Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(TPO-cre)1Shk/0 involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Jaf/Hras^tm1Jaf Trp53^tm1Brn/Trp53^tm1Brn Tg(TPO-cre)1Shk/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Mok/Hras⁺ Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	embryonic lethality during organogenesis, complete penetrance	J:135610
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)7Mok/0 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	no abnormal phenotype detected	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	prenatal lethality, incomplete penetrance	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0 involves: FVB/N	increased tumor incidence	J:107175

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23