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Hr Gene Detail
Summary
  • Symbol
    Hr
  • Name
    hairless
  • Synonyms
    ba, bldy, N, rh, rh-bmh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96223
    NCBI Gene: 15460
  • Gene Overview
    MyGene.info: HR
Location & Maps
more
  • Sequence Map
    Chr14:70552212-70573548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21337 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    HR, hair growth associated
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HR, hair growth associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
  • Links
    NCBI Gene ID: 55806
    neXtProt AC: NX_O43593

  • Chr Location
    8p21.2; chr8:22114419-22131053 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Hr mouse models; 3 with human HR associations

Human Disease Mouse Models
       Alopecia Universalis Congenita; ALUNC   OMIM: 203655 View 3 models
Atrichia with Papular Lesions; APL   OMIM: 209500 View 2 models
Hypotrichosis 4; HYPT4   OMIM: 146550 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    113 phenotypes from 27 alleles in 27 genetic backgrounds
    38 phenotypes from multigenic genotypes
    9 images
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    33
  • Chemically induced (ENU)
    10
  • Chemically induced (other)
    1
  • Spontaneous
    17
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    1 involving Hr
  • Incidental Mutations
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034183 VEGA Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
transcript OTTMUST00000086690 VEGA | MGI Sequence Detail 5278 Not Applicable  
polypeptide OTTMUSP00000046950 VEGA | MGI Sequence Detail 1211 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    166 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    Genomic 10
    cDNA 39
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10929, MGI:1890458, MGI:2661845
References
more
  • Summaries
    All 241
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 6
    Phenotypes 159
  • Earliest
    J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
  • Latest
    J:223401 Xiao Y, et al., Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7195-200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory