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Hr Gene Detail
Summary
  • Symbol
    Hr
  • Name
    lysine demethylase and nuclear receptor corepressor
  • Synonyms
    ba, bldy, N, rh, rh-bmh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96223
    NCBI Gene: 15460
  • Gene Overview
    MyGene.info: HR
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70554056-70573548 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96223
protein coding gene Chr14:70552212-70573548 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021543
protein coding gene Chr14:65209418-65231536 (+)
A/J MGP_AJ_G0021502
protein coding gene Chr14:63822150-63842746 (+)
AKR/J MGP_AKRJ_G0021478
protein coding gene Chr14:65734933-65755662 (+)
BALB/cJ MGP_BALBcJ_G0021508
protein coding gene Chr14:63584529-63605273 (+)
C3H/HeJ MGP_C3HHeJ_G0021285
protein coding gene Chr14:65450143-65470883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021947
protein coding gene Chr14:68121030-68141768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019487
protein coding gene Chr14:61658857-61679117 (+)
CAST/EiJ MGP_CASTEiJ_G0020802
protein coding gene Chr14:62047839-62068364 (+)
CBA/J MGP_CBAJ_G0021252
protein coding gene Chr14:70262549-70286138 (+)
DBA/2J MGP_DBA2J_G0021375
protein coding gene Chr14:63205969-63227252 (+)
FVB/NJ MGP_FVBNJ_G0021354
protein coding gene Chr14:62635748-62656575 (+)
LP/J MGP_LPJ_G0021446
protein coding gene Chr14:66450598-66471194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021383
protein coding gene Chr14:69148399-69169212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021971
protein coding gene Chr14:64997336-65018001 (+)
PWK/PhJ MGP_PWKPhJ_G0020546
protein coding gene Chr14:59973384-59996501 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020379
protein coding gene Chr14:60926060-60946804 (+)
WSB/EiJ MGP_WSBEiJ_G0020855
protein coding gene Chr14:65310015-65330716 (+)



Homology
more
  • Human Ortholog
    HR, HR, lysine demethylase and nuclear receptor corepressor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HR, HR, lysine demethylase and nuclear receptor corepressor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
  • Links
    NCBI Gene ID: 55806
    neXtProt AC: NX_O43593
    UniProt: O43593

  • Chr Location
    8p21.3; chr8:22114419-22131053 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Hr mouse models; 3 with human HR associations

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 2 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 28 alleles in 27 genetic backgrounds
    52 phenotypes from multigenic genotypes
    9 images
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15460 NCBI Gene Model | MGI Sequence Detail 19493 C57BL/6J ±  kb
    transcript NM_021877 RefSeq | MGI Sequence Detail 5501 Not Specified  
    polypeptide Q61645 UniProt | EBI | MGI Sequence Detail 1182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 10
      cDNA 40
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10929, MGI:1890458, MGI:2661845
    References
    more
    • Summaries
      All 254
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 6
      Phenotypes 165
    • Earliest
      J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
    • Latest
      J:265127 Cela EM, et al., Daily very low UV dose exposure enhances adaptive immunity, compared with a single high-dose exposure. Consequences for the control of a skin infection. Immunology. 2018 Jul;154(3):510-521

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory