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Hr Gene Detail
Summary
  • Symbol
    Hr
  • Name
    hairless
  • Synonyms
    ba, bldy, N, rh, rh-bmh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96223
    NCBI Gene: 15460
  • Gene Overview
    MyGene.info: HR
Location & Maps
more
  • Sequence Map
    Chr14:70552212-70573548 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21337 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    HR, HR, lysine demethylase and nuclear receptor corepressor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HR, HR, lysine demethylase and nuclear receptor corepressor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
  • Links
    NCBI Gene ID: 55806
    neXtProt AC: NX_O43593
    UniProt: O43593

  • Chr Location
    8p21.3; chr8:22114419-22131053 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Hr mouse models; 3 with human HR associations

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 2 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    116 phenotypes from 27 alleles in 27 genetic backgrounds
    38 phenotypes from multigenic genotypes
    9 images
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034183 VEGA Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
transcript OTTMUST00000086690 VEGA | MGI Sequence Detail 5278 Not Applicable  
polypeptide OTTMUSP00000046950 VEGA | MGI Sequence Detail 1211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    166 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    Genomic 10
    cDNA 39
    Primer pair 4
    Other 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10929, MGI:1890458, MGI:2661845
References
more
  • Summaries
    All 245
    Developmental Gene Expression 8
    Diseases 4
    Gene Ontology 5
    Phenotypes 160
  • Earliest
    J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
  • Latest
    J:238111 Shirokova V, et al., Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. Stem Cells. 2016 Jul;34(7):1896-908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory