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Hr
Gene Detail
Symbol

Name
ID
Hr
hairless
MGI:96223
Synonyms
ba, bldy, N, rh, rh-bmh
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr14:70552212-70573548 bp, + strand
From VEGA annotation of GRCm38

  21337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HR
Gene Tree: Hr

Human
homologs
HR, hair growth associated
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55806
neXtProt AC: NX_O43593

Human Synonyms: ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1

Human Chr (Location): 8p21.2; chr8:22114419-22131053 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human HR

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Chemically induced (ENU)(10) Spontaneous(17) Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
 
Human Diseases Modeled in Mice Using Hr (3)    Mutations Annotated to Human Diseases (4)    Phenotype Images(9)
Interactions
Hr interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (33)    Tissues (18)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 8
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(10) cDNA(39) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034183 (Evidence)
Ensembl Gene Model ENSMUSG00000022096 (Evidence)
Entrez Gene 15460 (Evidence)
UniGene 7598
DFCI TC1581479
DoTS DT.40152518
NIA Mouse Gene Index U015825
EC 1.14.11.-
Consensus CDS Project CCDS27257.1
International Mouse Phenotyping Consortium Status Hr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034183 VEGA Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
transcript OTTMUST00000086690 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000046950 VEGA | MGI Sequence Detail 1211 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
Protein Ontology PR:000008744 protein hairless
References
(Earliest) J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
(Latest) J:222871 Jain AK, et al., Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol. 2015 May 15;285(1):71-8
All references(239)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-10929, MGI:1890458, MGI:2661845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory