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Hr
Gene Detail
Symbol

Name
ID
Hr
hairless
MGI:96223
Synonyms
ba, bldy, N, rh, rh-bmh
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr14:70552212-70573548 bp, + strand
From VEGA annotation of GRCm38

  21337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Hr

Human
homologs
Human Homolog HR, hair growth associated
NCBI Gene ID 55806
neXtProt AC  NX_O43593
Human Synonyms  ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
Human Chr (Location)  8p21.2; chr8:22114419-22131053 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human HR
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Chemically induced (ENU)(9) Spontaneous(17) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
 
Human Diseases Modeled Using Mouse Hr (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(9)
Interactions
Hr interacts with 194 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (33)    Tissues (18)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 8
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(10) cDNA(39) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034183 (Evidence)
Ensembl Gene ModelENSMUSG00000022096 (Evidence)
Entrez Gene15460 (Evidence)
UniGene7598
DFCITC1581479
DoTSDT.40152518
NIA Mouse Gene IndexU015825
EC1.14.11.-
Consensus CDS ProjectCCDS27257.1
International Mouse Knockout Project StatusHr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034183 VEGA Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
transcript OTTMUST00000086690 VEGA | MGI Sequence Detail 5278 Not Applicable 
polypeptide OTTMUSP00000046950 VEGA | MGI Sequence Detail 1211 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(5)
Polymorphisms
All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
Protein Ontology PR:000008744 protein hairless
References
(Earliest) J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
(Latest) J:214829 Chang YC, et al., Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol Appl Pharmacol. 2014 Aug 13;280(2):236-244
All references(238)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-10929, MGI:1890458, MGI:2661845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory