Hr
Gene Detail

Symbol Name ID

Hr hairless MGI:96223

Synonyms

ba, bldy, N, rh, rh-bmh

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr14:70552212-70573548 bp, + strand From VEGA annotation of GRCm38   21337 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Hr ± 2 cM)

Gene Tree: Hr

Human ortholog

HR hair growth associated NCBI Gene ID 55806
Human Synonyms: ALUNC, AU, HSA277165, MUHH, MUHH1
Human Chr8:21971932-21988565 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human HR (3)

Alleles and phenotypes

All alleles(29) : Targeted(3) Transgenic(1) Spontaneous(17) Chemically induced(8)
 

Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.

 
Human Diseases Modeled Using Mouse Hr (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(9)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription, DNA-dependent, ...
Component	histone deacetylase complex, nuclear body, ...
Function	DNA binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (33)    Tissues (18)    Images (4)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	25
Northern blot	8

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(10) cDNA(39) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034183 (Evidence)
Ensembl Gene Model	ENSMUSG00000022096 (Evidence)
Entrez Gene	15460 (Evidence)
UniGene	7598
DFCI	TC1581479
DoTS	DT.40152518
NIA Mouse Gene Index	U015825
Consensus CDS Project	CCDS27257.1
International Mouse Knockout Project Status	Hr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034183	VEGA Gene Model | MGI Sequence Detail	21337	C57BL/6J
transcript	OTTMUST00000086690	VEGA | MGI Sequence Detail	5278	Not Applicable
polypeptide	OTTMUSP00000046950	VEGA | MGI Sequence Detail	1211	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003347	JmjC domain
Protein Ontology	PR:000008744	protein hairless

References

(Earliest) J:2405 Brooke HC, Hairless mice. J Hered. 1926;17:173-74
(Latest) J:192868 Kumpf S, et al., Hairless promotes PPARgamma expression and is required for white adipogenesis. EMBO Rep. 2012 Nov 6;13(11):1012-20
All references(222)

Other accession IDs

MGD-MRK-10929, MGI:1890458, MGI:2661845