Hr^Hp
Chemically induced Allele Detail

Summary

• Symbol: Hr^Hp
• Name: lysine demethylase and nuclear receptor corepressor; hairpoor
• MGI ID: MGI:3851914
• Gene: Hr Location: Chr14:70789652-70810988 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Hr^Hp page

Hair coat abnormalities in Hr^Hp/Hr⁺ and Hr^Hp/Hr^Hp mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU treatment induced a T-to-A transversion at position -292 upstream of the start codon in 5' UTR exon 2. This mutation changes putative initiation methionine codon ATG to AAG and abolishes translation of the corresponding upstream open reading frame. (J:150720)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hr Mutation: 84 strains or lines available

References

• Original: J:150720 Baek IC, et al., A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis. Mamm Genome. 2009 Jun;20(6):350-8
• All: 4 reference(s)