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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hr
lysine demethylase and nuclear receptor corepressor
MGI:96223
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Adam10Pied/Adam10+
Hrhr/Hr+
HRA/SkhKcl-Adam10Pied HrHr 		normal pigmentation phenotype J:262499
Adam10Pied/Adam10+
Hrhr/Hrhr
HRA/SkhKcl-Adam10Pied HrHr 		abnormal skin pigmentation J:262499
hairless J:262499
Adam10Pied/Adam10+
Hrhr/Hrhr
Tg(Dct-lacZ)A12Jkn/0
involves: C3HeB/FeJ * C57BL/6 * CBA * HRA/SkhKcl 		abnormal melanocyte morphology J:262499
hairless J:262499
increased melanocyte number J:262499
Adam10Pied/Adam10+
Hrhr/Hrhr
Tg(KRT14-Kitl*)4XTG2Bjl/0
involves: C57BL/6J * HRA/SkhKcl * SJL 		abnormal skin pigmentation J:262499
hairless J:262499
Adam10Pied/Adam10+
Cd44tm1Hbg/Cd44tm1Hbg
Hrhr/Hrhr
involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl 		abnormal skin pigmentation J:262499
hairless J:262499
Adam10Pied/Adam10Pied
Hrhr/Hrhr
involves: CAST/EiJ * HRA/SkhKcl 		abnormal heart looping J:262499
abnormal neural tube morphology J:262499
abnormal somite border morphology J:262499
caudal body truncation J:262499
decreased embryo size J:262499
enlarged pericardium J:262499
preweaning lethality, complete penetrance J:262499
small pharyngeal arch J:262499
telencephalon hypoplasia J:262499
Adam10Pied/Adam10tm1Psa
Hrhr/Hrhr
involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/SkhKcl 		abnormal heart looping J:262499
abnormal neural tube morphology J:262499
abnormal somite border morphology J:262499
caudal body truncation J:262499
decreased embryo size J:262499
enlarged pericardium J:262499
small pharyngeal arch J:262499
telencephalon hypoplasia J:262499
Adam10tm1Psa/Adam10+
Hrhr/Hrhr
involves: 129P2/OlaHsd * C3HeB/FeJ * HRA/Skh 		abnormal skin pigmentation J:262499
hairless J:262499
Ercc1tm1Dwm/Ercc1tm2Dwm
Hrhr/Hrhr
Tg(KRT5-cre)5132Jlj/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J * MF1 		abnormal hepatocyte morphology J:115849
decreased birth body size J:115849
increased incidence of tumors by UV-induction J:115849
increased sensitivity to skin irradiation J:115849
postnatal lethality, incomplete penetrance J:115849
Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
involves: 129P2/OlaHsd 		increased incidence of tumors by UV-induction J:79734
increased lymphoma incidence J:79734
increased mortality induced by ionizing radiation J:79734
increased skin papilloma incidence J:79734
increased skin squamous cell carcinoma incidence J:79734
increased skin tumor incidence J:79734
premature death J:79734
Hrhr/Hrhr
Msh2tm1Htr/Msh2tm1Htr
Xpatm1Tnka/Xpatm1Tnka
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased incidence of tumors by UV-induction J:79734
increased lymphoma incidence J:79734
increased mortality induced by ionizing radiation J:79734
increased skin papilloma incidence J:79734
increased skin squamous cell carcinoma incidence J:79734
increased skin tumor incidence J:79734
premature death J:79734
Hrhr/Hrhr
Ptger2tm1Brey/Ptger2+
involves: 129S6/SvEvTac * C57BL/6 * SKH1 		abnormal skin physiology J:117581
normal neoplasm J:117581
Hrhr/Hrhr
Ptger2tm1Brey/Ptger2tm1Brey
involves: 129S6/SvEvTac * C57BL/6 * SKH1 		abnormal skin physiology J:117581
abnormal tumor morphology J:117581
decreased incidence of tumors by UV induction J:117581
increased tumor growth/size J:117581
Hrhr/Hrhr
Ptgs1tm1Unc/Ptgs1+
involves: 129P2/OlaHsd * C57BL/6 * SKH1 		decreased prostaglandin level J:121635
increased cell proliferation J:121635
normal neoplasm J:121635
Hrhr/Hrhr
Ptgs2tm1Unc/Ptgs2+
involves: 129P2/OlaHsd * C57BL/6 * SKH1 		decreased incidence of tumors by UV induction J:121635
decreased prostaglandin level J:121635
increased cell proliferation J:121635
Hrhr/Hrhr
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * SKH1 		premature death J:121635
Hrhr/Hrhr
Tg(CD2-Stat6*V625A*T626A)78Mhk/0
involves: C3H * SKH1 		abnormal cornea morphology J:230018
abnormal eyelid morphology J:230018
abnormal physiological neovascularization J:230018
blepharitis J:230018
edema J:230018
eye inflammation J:230018
loss of eyelid cilia J:230018
Meibomian gland inflammation J:230018
uveitis J:230018
Hrhr/Hrhr
Tg(KRT14-Birc5)19Gros/0
involves: C3H * C57BL/6 * SKH1 		decreased incidence of tumors by UV induction J:95011
decreased sensitivity to skin irradiation J:95011
increased squamous cell carcinoma incidence J:95011
Hrhr/Hrhr
Tg(KRT14-Ptgs2)1Sumf/0
involves: C57BL/6 * DBA/2 * FVB/N * SKH1 		decreased cell proliferation J:121635
increased incidence of tumors by UV-induction J:121635
increased prostaglandin level J:121635
Hrhr/Hrhr
Xpatm1Tnka/Xpatm1Tnka
involves: C57BL/6 * CBA 		increased skin tumor incidence J:79734
Hrtm1Cct/Hrtm1Cct
Tg(KRT14-Hr)551Cct/0
involves: 129/Sv * C57BL/6 * SJL 		abnormal hair follicle morphology J:102493
abnormal skin morphology J:102493
alopecia J:102493
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory