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Hgf
Gene Detail
 Symbol
Name
ID
Hgf
hepatocyte growth factor
MGI:96079
Synonyms C230052L06Rik, HGF/SF, NK1, NK2, scatter factor, SF/HGF
Feature Type protein coding gene
Genetic Map
Chromosome 5
7.07 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:16553550-16619439 bp, + strand
From NCBI annotation of GRCm38

  65890 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: hepatocyte growth factor/macrophage stimulating protein 1
Gene Tree: Hgf

Human
homologs
Human Homolog HGF, hepatocyte growth factor (hepapoietin A; scatter factor)
NCBI Gene ID 3082
neXtProt AC  NX_P14210
Human Synonyms  DFNB39, F-TCF, HGFB, HPTA, SF
Human Chr (Location)  7q21.1; chr7:81700166-81770438 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HGF
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality.
 
Interactions
Hgf interacts with 141 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process activation of MAPK activity, cell chemotaxis, ...
Component extracellular space, membrane
Function catalytic activity, chemoattractant activity, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (488)    Tissues (243)    Images (73)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 31
RNA in situ 186
Northern blot 30
Western blot 1
RT-PCR 233
RNase protection 7
cDNA source data(33)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(10) cDNA(34) Primer pair(11) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028864 (Evidence)
Entrez Gene15234 (Evidence)
UniGene267078
DFCITC1587469, TC1590254, TC1610327
DoTSDT.101723518, DT.482336, DT.91286333, DT.94128859, DT.94234722
NIA Mouse Gene IndexU005309
PDB3HMR, 4IUA, 2QJ4
Consensus CDS ProjectCCDS19097.1
International Mouse Knockout Project StatusHgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15234 NCBI Gene Model | MGI Sequence Detail 65890 C57BL/6J ±  kb
transcript NM_001289458 RefSeq | MGI Sequence Detail 2838 C57BL/6 
polypeptide Q08048 UniProt | EBI | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(548 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003609 Apple-like
InterPro IPR027284 Hepatocyte growth factor
InterPro IPR024174 Hepatocyte growth factor/macrophage stimulating protein 1
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR003014 PAN-1 domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008534 hepatocyte growth factor
Graphical View of Protein Domain Structure
References (Earliest) J:909 Szpirer C, et al., Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. 1992 Jun;13(2):293-300
(Latest) J:201612 Takeda S, et al., HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013 Jul 1;123(7):3154-65
All references(159)
Other
accession IDs
MGD-MRK-10704, MGI:2443459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory