Hgf
Gene Detail

Symbol Name ID

Hgf hepatocyte growth factor MGI:96079

Synonyms

C230052L06Rik, HGF/SF, NK1, NK2, scatter factor, SF/HGF

Feature Type

protein coding gene

Genetic Map

Chromosome 5

7.07 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr5:16553550-16619439 bp, + strand From NCBI annotation of GRCm38   65890 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: hepatocyte growth factor/macrophage stimulating protein 1
Gene Tree: Hgf

Human homologs

Human Homolog		HGF, hepatocyte growth factor (hepapoietin A; scatter factor)
NCBI Gene ID		3082
neXtProt AC		NX_P14210
Human Synonyms		DFNB39, F-TCF, HGFB, HPTA, SF
Human Chr (Location)		7q21.1; chr7:81331444-81399452 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HGF

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	activation of MAPK activity, cell chemotaxis, ...
Component	extracellular space
Function	catalytic activity, chemoattractant activity, ...

External Resources: FuncBase

Expression

Literature Summary: (54 records)
Data Summary: Results (455)    Tissues (225)    Images (56)
Theiler Stages: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	176
Northern blot	30
Western blot	1
RT-PCR	219
RNase protection	7

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(10) cDNA(36) Primer pair(10) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000028864 (Evidence)
Entrez Gene	15234 (Evidence)
UniGene	267078
DFCI	TC1587469, TC1590254, TC1610327
DoTS	DT.101723518, DT.482336, DT.91286333, DT.94128859, DT.94234722
NIA Mouse Gene Index	U005309
PDB	3HMR, 2QJ4
Consensus CDS Project	CCDS19097.1
International Mouse Knockout Project Status	Hgf

Sequences

Length	Strain/Species
genomic	15234	NCBI Gene Model | MGI Sequence Detail	65890	C57BL/6J
transcript	NM_010427	RefSeq | MGI Sequence Detail	2755	C57BL/6
polypeptide	Q08048	UniProt | EBI | MGI Sequence Detail	728	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(482 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003609	Apple-like
InterPro	IPR024174	Hepatocyte growth factor/macrophage stimulating protein 1
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR003014	PAN-1 domain
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
Protein Ontology	PR:000008534	hepatocyte growth factor

Graphical View of Protein Domain Structure

References

(Earliest) J:909 Szpirer C, et al., Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. 1992 Jun;13(2):293-300
(Latest) J:194131 Sugiyama D, et al., TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013 Feb;130(2-3):195-206
All references(152)

Other accession IDs

MGD-MRK-10704, MGI:2443459