Hesx1
Gene Detail

Symbol Name ID

Hesx1 homeobox gene expressed in ES cells MGI:96071

Synonyms

HES-1, Rpx

Feature Type

protein coding gene

Genetic Map

Chromosome 14

16.09 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:27000362-27002329 bp, + strand From VEGA annotation of GRCm38   1968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeobox expressed in ES cells 1
Gene Tree: Hesx1

Human homologs

Human Homolog		HESX1, HESX homeobox 1
NCBI Gene ID		8820
neXtProt AC		NX_Q9UBX0
Human Synonyms		ANF, CPHD5, RPX
Human Chr (Location)		3p14.3; chr3:57231944-57234280 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HESX1

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Homozygous mice show significant perinatal and postnatal lethality. Deficiency is manifested as brain, endocrine/exocrine and sensory organ developmental abnormalities in many embryos. Most mice surviving past birth display eye defects such as anophthalmia or microphthalmia.

 
Human Diseases Modeled Using Mouse Hesx1 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	brain development, forebrain morphogenesis, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (108 records)
Data Summary: Results (298)    Tissues (227)    Images (61)
Theiler Stages: 2, 3, 4, 5, 9, 10, 11, 12, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	233
Northern blot	12
RT-PCR	27
RNase protection	26

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(2) cDNA(20) Primer pair(7) Other(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037602 (Evidence)
Ensembl Gene Model	ENSMUSG00000040726 (Evidence)
Entrez Gene	15209 (Evidence)
UniGene	4802
DFCI	TC1590925
DoTS	DT.87061255
NIA Mouse Gene Index	U015418
Consensus CDS Project	CCDS26884.1
International Mouse Knockout Project Status	Hesx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037602	VEGA Gene Model | MGI Sequence Detail	1968	C57BL/6J
transcript	OTTMUST00000096976	VEGA | MGI Sequence Detail	1141	Not Applicable
polypeptide	OTTMUSP00000054269	VEGA | MGI Sequence Detail	185	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000008523	homeobox expressed in ES cells 1

References

(Earliest) J:3298 Thomas PQ, et al., HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes. Nucleic Acids Res. 1992 Nov 11;20(21):5840
(Latest) J:191667 Jayakody SA, et al., SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
All references(145)

Other accession IDs

MGD-MRK-10694, MGD-MRK-14207