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Hesx1
Gene Detail
Symbol

Name
ID
Hesx1
homeobox gene expressed in ES cells
MGI:96071
Synonyms
HES-1, Rpx
Feature Type
protein coding gene
Genetic Map
Chromosome 14
16.09 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:27000362-27002329 bp, + strand
From VEGA annotation of GRCm38

  1968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeobox expressed in ES cells 1
Gene Tree: Hesx1

Human
homologs
Human Homolog HESX1, HESX homeobox 1
NCBI Gene ID 8820
neXtProt AC  NX_Q9UBX0
Human Synonyms  ANF, CPHD5, RPX
Human Chr (Location)  3p14.3; chr3:57197838-57227507 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HESX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice show significant perinatal and postnatal lethality. Deficiency is manifested as brain, endocrine/exocrine and sensory organ developmental abnormalities in many embryos. Most mice surviving past birth display eye defects such as anophthalmia or microphthalmia.
 
Human Diseases Modeled Using Mouse Hesx1 (2)    Alleles Annotated to Human Diseases(3)   
Interactions
Hesx1 interacts with 38 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process brain development, forebrain morphogenesis, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (113 records)
Data Summary: Results (306)    Tissues (227)    Images (78)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
Northern blot 12
RT-PCR 18
RNase protection 26
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(2) cDNA(20) Primer pair(7) Other(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037602 (Evidence)
Ensembl Gene ModelENSMUSG00000040726 (Evidence)
Entrez Gene15209 (Evidence)
UniGene4802
DFCITC1590925
DoTSDT.87061255
NIA Mouse Gene IndexU015418
Consensus CDS ProjectCCDS26884.1
International Mouse Knockout Project StatusHesx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037602 VEGA Gene Model | MGI Sequence Detail 1968 C57BL/6J ±  kb
transcript OTTMUST00000096976 VEGA | MGI Sequence Detail 1141 Not Applicable 
polypeptide OTTMUSP00000054269 VEGA | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008523 homeobox expressed in ES cells 1
References
(Earliest) J:3298 Thomas PQ, et al., HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes. Nucleic Acids Res. 1992 Nov 11;20(21):5840
(Latest) J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
All references(151)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-10694, MGD-MRK-14207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory