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Hesx1 Gene Detail
Summary
  • Symbol
    Hesx1
  • Name
    homeobox gene expressed in ES cells
  • Synonyms
    HES-1, Rpx
  • Feature Type
    protein coding gene
  • IDs
    MGI:96071
    NCBI Gene: 15209
  • Gene Overview
    MyGene.info: HESX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:27000362-27002329 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1968 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.09 cM, cytoband A3-B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HESX1, HESX homeobox 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HESX1, HESX homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANF, CPHD5, RPX
  • Links
    NCBI Gene ID: 8820
    neXtProt AC: NX_Q9UBX0
    UniProt: Q9UBX0

  • Chr Location
    3p14.3; chr3:57197838-57227643 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Hesx1 mouse models; 1 with human HESX1 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice show significant perinatal and postnatal lethality. Deficiency is manifested as brain, endocrine/exocrine and sensory organ developmental abnormalities in many embryos. Most mice surviving past birth display eye defects such as anophthalmia or microphthalmia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037602 VEGA Gene Model | MGI Sequence Detail 1968 C57BL/6J ±  kb
    transcript OTTMUST00000096976 VEGA | MGI Sequence Detail 1141 Not Applicable  
    polypeptide OTTMUSP00000054269 VEGA | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      96 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 20
      Primer pair 7
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10694, MGD-MRK-14207
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 124
      Diseases 3
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:3298 Thomas PQ, et al., HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes. Nucleic Acids Res. 1992 Nov 11;20(21):5840
    • Latest
      J:255932 Mario Gonzalez-Meljem J, et al., Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. Nat Commun. 2017 Nov 28;8(1):1819

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory