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Hba Complex/Cluster/Region Detail
Summary
  • Symbol
    Hba
  • Name
    hemoglobin alpha chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96014
    NCBI Gene: 15121
  • Cluster Members
    Hba-x, Hba-a1, Hba-a2 (3 members)
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 11, cytoband A
  • Mapping Data
    78 experiments
Human Diseases
more
  • Diseases
    3 with Hba mouse models

Human Disease Mouse Models
       Alpha-Thalassemia   OMIM: 604131 View 7 models
Hemoglobin--Alpha Locus 1; HBA1   OMIM: 141800 View 2 models
Hydrops Fetalis, Nonimmune; NIHF   OMIM: 236750 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    21 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 14 alleles in 16 genetic backgrounds
    71 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    10
  • Genomic Mutations
    1 involving Hba
Mice homozygous for one knock-out allele exhibit lethality during fetal development, reduced size and anemia. Mice homozygous for another knock-out allele exhibit preweaning lethality, pallor and anemia.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
less
Polymorphisms
less
  • RFLP
Molecular
Reagents
less
  • All nucleic 22
    Genomic 9
    cDNA 4
    Other 9
Other
Accession IDs
less
MGD-MRK-10623
References
more
  • Summaries
    All 204
    Developmental Gene Expression 19
    Diseases 21
    Phenotypes 97
  • Earliest
    J:107 POPP RA, Studies on the mouse hemoglobin loci. II. Position of the hemoglobin locus with respect to albinism and shaker-1 loci. J Hered. 1962 Mar-Apr;53:73-80
  • Latest
    J:232634 Sparkenbaugh EM, et al., Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. Blood. 2016 Mar 10;127(10):1371-3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory