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Hba
Complex/Cluster/Region Detail
 Symbol
Name
ID
Cluster members
Hba
hemoglobin alpha chain complex
MGI:96014
Hba-x, Hba-a1, Hba-a2 (3 members)
Feature Type complex/cluster/region
Genetic Map
Chromosome 11
cytoband A

Mapping data(78)
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Chemically induced (other)(1) Radiation induced(2) Targeted(10)
 
Mice homozygous for one knock-out allele exhibit lethality during fetal development, reduced size and anemia. Mice homozygous for another knock-out allele exhibit preweaning lethality, pallor and anemia.
 
Human Diseases Modeled Using Mouse Hba (3)    Alleles Annotated to Human Diseases(5)   
Expression
Literature Summary: (19 records)
Data Summary: Results (16)    Tissues (15)   
Theiler Stages: 10, 18, 20, 21, 23, 25, 28
Assay TypeResults
Northern blot 12
RNase protection 2
Nuclease S1 2
Molecular
reagents
All nucleic(22) Genomic(9) cDNA(4) Other(9)
Other database
links
Entrez Gene15121
Polymorphisms RFLP(5) : SNPs within 2kb(0 from dbSNP Build 137)
References (Earliest) J:107 POPP RA, Studies on the mouse hemoglobin loci. II. Position of the hemoglobin locus with respect to albinism and shaker-1 loci. J Hered. 1962 Mar-Apr;53:73-80
(Latest) J:210886 Chen G, et al., Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Blood. 2014 Jun 12;123(24):3818-27
All references(188)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-10623

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/23/2014
MGI 5.18
The Jackson Laboratory